{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:03:33Z","timestamp":1776344613737,"version":"3.51.2"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Aim of the study is to compare the agreement between whole-body low-dose computed tomography (WBLDCT) and magnetic resonance imaging (WBMRI) in the evaluation of bone marrow involvement in patients with multiple myeloma (MM). Patients with biopsy-proven MM, who underwent both WBLDCT and WBMRI were retrospectively enrolled. After identifying the presence of focal bone involvement (focal infiltration pattern), the whole skeleton was divided into five anatomic districts (skull, spine, sternum and ribs, pelvis, and limbs). Patients were grouped according to the number and location of the lytic lesions (&lt;5, 5\u201320, and &gt;20) and Durie and Salmon staging system. The agreement between CT and MRI regarding focal pattern, staging, lesion number, and distribution was assessed using the Cohen Kappa statistics. The majority of patients showed focal involvement. According to the distribution of the focal lesions and Durie Salmon staging, the agreement between CT and MRI was substantial or almost perfect (all \u03ba &gt; 0.60). The agreement increased proportionally with the number of lesions in the pelvis and spine (\u03ba = 0.373 to \u03ba = 0.564, and \u03ba = 0.469\u20130.624), while for the skull the agreement proportionally decreased without reaching a statistically significant difference (p &gt; 0.05). In conclusion, WBLDCT showed an almost perfect agreement in the evaluation of focal involvement, staging, lesion number, and distribution of bone involvement in comparison with WBMRI.<\/jats:p>","DOI":"10.3390\/diagnostics11050857","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T04:05:32Z","timestamp":1620705932000},"page":"857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Whole Body Low Dose Computed Tomography (WBLDCT) Can Be Comparable to Whole-Body Magnetic Resonance Imaging (WBMRI) in the Assessment of Multiple Myeloma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-7047","authenticated-orcid":false,"given":"Davide","family":"Ippolito","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, \u201cSan Gerardo\u201d Hospital, via Pergolesi 33, 20900 Monza, MB, Italy"},{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Giandola","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, \u201cSan Gerardo\u201d Hospital, via Pergolesi 33, 20900 Monza, MB, Italy"},{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-802X","authenticated-orcid":false,"given":"Cesare","family":"Maino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, \u201cSan Gerardo\u201d Hospital, via Pergolesi 33, 20900 Monza, MB, Italy"},{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-791X","authenticated-orcid":false,"given":"Davide","family":"Gandola","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, \u201cSan Gerardo\u201d Hospital, via Pergolesi 33, 20900 Monza, MB, Italy"},{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ragusi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, \u201cSan Gerardo\u201d Hospital, via Pergolesi 33, 20900 Monza, MB, Italy"},{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-9429","authenticated-orcid":false,"given":"Pietro Andrea","family":"Bonaffini","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"},{"name":"Department of Diagnostic Radiology, H Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo, BG, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Sironi","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, MB, Italy"},{"name":"Department of Diagnostic Radiology, H Papa Giovanni XXIII, Piazza OMS 1, 24127 Bergamo, BG, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3324\/haematol.2015.124115","article-title":"A magnetic resonance imaging-based prognostic scoring system to predict outcome in transplant-eligible patients with multiple myeloma","volume":"100","author":"Mai","year":"2015","journal-title":"Haematologica"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood-2018-04-842880","article-title":"The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma","volume":"132","author":"Rasche","year":"2018","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.biopha.2006.07.008","article-title":"Role of 18F-FDG-PET and PET\/CT imaging in thyroid cancer","volume":"60","author":"Nanni","year":"2006","journal-title":"Biomed. 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