{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:03:18Z","timestamp":1777957398294,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K19157"],"award-info":[{"award-number":["19K19157"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein\u2013Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.<\/jats:p>","DOI":"10.3390\/diagnostics11061039","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:12:13Z","timestamp":1622805133000},"page":"1039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5878-8871","authenticated-orcid":false,"given":"Daisuke","family":"Takeda","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-7166","authenticated-orcid":false,"given":"Manabu","family":"Shigeoka","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tenyu","family":"Sugano","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanae","family":"Yatagai","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"ref_1","unstructured":"El-Naggar, A.K., and Centre International de Recherche sur le cancer (2017). WHO Classification of Head and Neck Tumours, IARC Publications."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.anndiagpath.2018.10.008","article-title":"Virus-associated carcinomas of the head & neck: Update from the 2017 WHO classification","volume":"38","author":"Holmes","year":"2019","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ajcp\/103.3.308","article-title":"The role of epstein-barr virus in lymphoepithelioma-like carcinomas","volume":"103","author":"Iezzoni","year":"1995","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ijc.2910280308","article-title":"Association of Epstein-Barr virus with nasopharyngeal carcinoma in alaskan native patients: Serum antibodies and tissue EBNA and DNA","volume":"28","author":"Lanier","year":"1981","journal-title":"Int. J. Cancer"},{"key":"ref_5","first-page":"132","article-title":"Epstein-Barr virus infection of sinonasal lymphoepithelial carcinoma in Guangzhou","volume":"114","author":"Zong","year":"2001","journal-title":"Chin. Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.pas.0000209829.16607.cd","article-title":"Microsatellite instability in nasopharyngeal and lymphoepithelial carcinomas of the head and neck","volume":"30","author":"Sckolnick","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Brierley, J.D., Gospodarowicz, M.K., and Wittekind, C. (2016). TNM Classification of Malignant Tumours, John Wiley & Sons.","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/019459988910000410","article-title":"Lymphoepithelioma of the Oropharynx","volume":"100","author":"Bansberg","year":"1989","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/(SICI)1097-0142(19980415)82:8<1556::AID-CNCR18>3.0.CO;2-3","article-title":"Nonnasopharyngeal lymphoepithelioma of the head and neck","volume":"82","author":"Dubey","year":"1998","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000302139","article-title":"Schmincke\u2019s Tumor, Carcinoma of the Base of the Tongue c T1-2, cN2c M0\u2013A Case Report","volume":"3","author":"Merz","year":"2010","journal-title":"Case Rep. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.18632\/oncotarget.6770","article-title":"The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1097\/PAS.0000000000000946","article-title":"Desmoplastic Pattern at the Tumor Front Defines Poor-prognosis Subtypes of Colorectal Cancer","volume":"41","author":"Ueno","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00428-019-02580-2","article-title":"Prognostic significance of histological categorization of desmoplastic reaction in colorectal liver metastases","volume":"475","author":"Ao","year":"2019","journal-title":"Virchows Archiv"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00428-020-02930-5","article-title":"Stromal categorization in early oral tongue cancer","volume":"478","author":"Almangush","year":"2021","journal-title":"Virchows Archiv"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10147-010-0169-z","article-title":"Oral premalignant lesions: From the pathological viewpoint","volume":"16","author":"Izumo","year":"2011","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00428-013-1412-6","article-title":"Differentiated dysplasia is a frequent precursor or associated lesion in invasive squamous cell carcinoma of the oral cavity and pharynx","volume":"462","author":"Arsenic","year":"2013","journal-title":"Virchows Archiv"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/jomfp.JOMFP_13_19","article-title":"Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders","volume":"23","author":"Ranganathan","year":"2019","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.tripleo.2008.01.016","article-title":"A rare case of lymphoepithelial carcinoma of the lip","volume":"105","author":"Mahomed","year":"2008","journal-title":"Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4999\/uhod.12037","article-title":"Lymphoepithelial Carcinoma of the Lower Lip: Report of a Case","volume":"24","author":"Gultekin","year":"2014","journal-title":"Int. J. Hematol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2020138","DOI":"10.4322\/acr.2020.138","article-title":"EBV-negative lymphoepithelial-like carcinoma of the lower lip","volume":"10","author":"Almeida","year":"2019","journal-title":"Autops. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ajoms.2017.03.008","article-title":"Immunophenotypic analysis of tumor infiltrating lymphocytes in Epstein-Barr virus-negative lymphoepithelial carcinoma of the oral cavity: Report of a case","volume":"29","author":"Shimizu","year":"2017","journal-title":"J. Oral Maxillofac. Surg. Med. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/jjco\/hys141","article-title":"General rules for clinical and pathological studies on oral cancer: A synopsis","volume":"42","author":"Izumo","year":"2012","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1054\/ijom.2001.0148","article-title":"Lymphoepithelioma-like carcinoma of oral cavity: Report of three cases and literature review","volume":"31","author":"Chow","year":"2002","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12105-011-0278-7","article-title":"Lymphoepithelial carcinoma: Two case reports and a systematic review of oral and sinonasal cases","volume":"5","author":"Hirvikoski","year":"2011","journal-title":"Head Neck Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.semdp.2014.12.004","article-title":"Lymphoepithelial-like carcinomas of the head and neck","volume":"32","author":"Wenig","year":"2015","journal-title":"Semin. Diagn. 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