{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:09:50Z","timestamp":1760234990570,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>For therapeutic decisions regarding uni- or biventricular surgical repair in congenital heart disease (CHD), left ventricular mass (LVM) is an important factor. The aim of this retrospective study was to determine the LVM of infants with CHD in thoracic computed tomography angiographies (CTAs) and to evaluate its usefulness as a prognostic parameter, with special attention paid to hypoplastic left heart (HLH) patients. Manual segmentation of the left ventricular endo- and epicardial volumes was performed in CTAs of 132 infants. LVMs were determined from these volumes and normalized to body surface area. LVMs of patients with different types of CHD were compared to each other using analyses of variances (ANOVA). An LVM cutoff for discrimination between uni- and biventricular repair was determined using receiver operating characteristics. Survival rates were calculated using Kaplan\u2013Meier statistics. Patients with a clinical diagnosis of an HLH had significantly lower mean LVM (21.88 g\/m2) compared to patients without applicable disease (50.22 g\/m2; p &lt; 0.0001) and compared to other CHDs, including persistent truncus arteriosus, left ventricular outflow tract obstruction, transposition of the great arteries, pulmonary artery stenosis or atresia, and double-outlet right ventricle (all, p &lt; 0.05). The LVM cutoff for uni- vs. biventricular surgery was 33.9 g\/m2 (sensitivity: 82.3%; specificity: 73.7%; PPV: 94.9%). In a subanalysis of HLH patients, a sensitivity of 50.0%, specificity of 100%, PPV of 100%, and NPV of 83.3% was determined. Patient survival was not significantly different between the surgical approaches or between patients with LVM above or below the cutoff. LVM can be measured in chest CTA of newborns with CHD and can be used as a prognostic factor.<\/jats:p>","DOI":"10.3390\/diagnostics11071215","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T02:59:47Z","timestamp":1625540387000},"page":"1215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of CTA-Derived Left Ventricular Mass in Neonates with Congenital Heart Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-5526","authenticated-orcid":false,"given":"Stephan","family":"Ellmann","sequence":"first","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie-Marie","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-5411","authenticated-orcid":false,"given":"Rafael","family":"Heiss","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"},{"name":"Imaging Science Institute Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouhayla","family":"El Amrani","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"W\u00fcst","sequence":"additional","affiliation":[{"name":"Imaging Science Institute Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"},{"name":"Department of Radiology, Martha Maria Hospital Nuremberg, 90491 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Rompel","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Rueffer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-6647","authenticated-orcid":false,"given":"Robert","family":"Cesnjevar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery, University Hospital Erlangen, Loschgestra\u00dfe 15, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-3416","authenticated-orcid":false,"given":"Sven","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Hospital Erlangen, Loschgestra\u00dfe 15, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Uder","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"},{"name":"Imaging Science Institute Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-850X","authenticated-orcid":false,"given":"Matthias S.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany"},{"name":"Imaging Science Institute Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Miranovi\u0107, V. (2014). The Incidence of Congenital Heart Disease: Previous Findings and Perspectives. Srp. Arh. Celok. Lek., 142.","DOI":"10.2298\/SARH1404243M"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/01.CIR.96.4.1233","article-title":"Anatomic Features and Surgical Strategies in Double-Outlet Right Ventricle","volume":"96","author":"Kleinert","year":"1997","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1053\/tc.2000.6504","article-title":"The role of the Fontan procedure in the surgical treatment of congenital heart malformations with double-outlet right ventricle","volume":"3","author":"Puga","year":"2000","journal-title":"Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Annu."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11936-005-0022-2","article-title":"Double outlet right ventricle: Opinions regarding management","volume":"7","author":"Cetta","year":"2005","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/icvts\/ivt495","article-title":"Two-ventricle repair for complex congenital heart defects palliated towards single-ventricle repair","volume":"18","author":"Kottayil","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gerdts, E., Rosseb\u00f8, A.B., Pedersen, T.R., Cioffi, G., L\u00f8nnebakken, M.T., Cramariuc, D., Rogge, B.P., and Devereux, R.B. (2015). Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate Aortic Valve Stenosis. Circ. Cardiovasc. Imaging, 8.","DOI":"10.1161\/CIRCIMAGING.115.003644"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1001\/jama.292.19.2350","article-title":"Prognostic significance of left ventricular mass change during treatment of hypertension","volume":"292","author":"Devereux","year":"2004","journal-title":"J. Am. Med. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jcmg.2015.04.019","article-title":"LV Mass as a Predictor of CVD Events in Older Adults with and Without Metabolic Syndrome and Diabetes","volume":"8","author":"Hoang","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0003-4975(98)00579-7","article-title":"Which hearts are unsuitable for biventricular correction?","volume":"66","author":"Anderson","year":"1998","journal-title":"Ann. Thorac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1161\/01.CIR.84.6.2325","article-title":"Predictors of survival in neonates with critical aortic stenosis","volume":"84","author":"Rhodes","year":"1991","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0735-1097(91)90765-2","article-title":"Echocardiographic estimation of critical left ventricular size in infants with isolated aortic valve stenosis","volume":"18","author":"Parsons","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0022-5223(19)36737-6","article-title":"Critical aortic stenosis in early infancy. Anatomic and echocardiographic substrates of successful open valvotomy","volume":"101","author":"Leung","year":"1991","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/RTI.0b013e3181d7e898","article-title":"Pushing the envelope: New computed tomography techniques for cardiothoracic imaging","volume":"25","author":"Flohr","year":"2010","journal-title":"J. Thorac. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00330-012-2479-1","article-title":"Accuracy, image quality and radiation dose comparison of high-pitch spiral and sequential acquisition on 128-slice dual-source CT angiography in children with congenital heart disease","volume":"22","author":"Nie","year":"2012","journal-title":"Eur. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10554-018-01526-0","article-title":"Image quality and radiation dose of two prospective ECG-triggered protocols using 128-slice dual-source CT angiography in infants with congenital heart disease","volume":"35","author":"Chen","year":"2019","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-5223(99)70144-3","article-title":"Left heart hypoplasia and neonatal aortic arch obstruction: Is the Rhodes left ventricular adequacy score applicable?","volume":"118","author":"Tani","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0003-4975(99)00621-9","article-title":"Left ventricular growth in selected hypoplastic left ventricles: Outcome after repair of coarctation of aorta","volume":"68","author":"Alboliras","year":"1999","journal-title":"Ann. Thorac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0003-4975(98)00803-0","article-title":"Biventricular repair in neonates with hypoplastic left heart complex","volume":"66","author":"Tchervenkov","year":"1998","journal-title":"Ann. Thorac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00247-012-2464-5","article-title":"Left ventricle volume measured by cardiac CT in an infant with a small left ventricle: A new and accurate method in determining uni- or biventricular repair","volume":"43","author":"Kim","year":"2013","journal-title":"Pediatr. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00330-010-2036-8","article-title":"Paediatric cardiac computed tomography: A review of imaging techniques and radiation dose consideration","volume":"21","author":"Young","year":"2011","journal-title":"Eur. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1148\/radiol.10100047","article-title":"Multisection CT protocols: Sex- and age-specific conversion factors used to determine effective dose from dose-length product","volume":"257","author":"Deak","year":"2010","journal-title":"Radiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: A report from the American Society of Echocardiography\u2019s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/hrt.2003.023234","article-title":"Left ventricular myocardial mass determination by contrast enhanced colour Doppler compared with magnetic resonance imaging","volume":"91","author":"Bezante","year":"2005","journal-title":"Heart"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: An R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0022-5223(96)70304-5","article-title":"Surgical approaches for double-outlet right ventricle or transposition of the great arteries associated with straddling atrioventricular valves","volume":"111","author":"Serraf","year":"1996","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0003-4975(10)62771-3","article-title":"Anatomic correction of double-outlet right ventricle with subpulmonary ventricular septal defect (the \u201cTaussig-Bing\u201d anomaly)","volume":"41","author":"Kanter","year":"1986","journal-title":"Ann. Thorac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/j.pcsu.2007.12.003","article-title":"Intracardiac repair of double outlet right ventricle","volume":"11","year":"2008","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S1010-7940(01)00897-1","article-title":"Surgical management and indication of left ventricular retraining in arterial switch for transposition of the great arteries with intact ventricular septum","volume":"20","author":"Piot","year":"2001","journal-title":"Eur. J. Cardio-Thoracic Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.pcsu.2013.01.003","article-title":"Strategies to maintain biventricular circulation in patients with high-risk anatomy","volume":"16","author":"Emani","year":"2013","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0003-4975(98)00570-0","article-title":"Echocardiography of hypoplastic ventricles","volume":"66","author":"Silverman","year":"1998","journal-title":"Ann. Thorac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/CIRCULATIONAHA.113.006191","article-title":"Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial","volume":"129","author":"Newburger","year":"2014","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1161\/CIRCULATIONAHA.117.029375","article-title":"Transplant-free survival and interventions at 6 years in the SVR trial","volume":"137","author":"Newburger","year":"2018","journal-title":"Circulation"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"(2017). ECHSA congenital database. Cardiol. Young, 27, S1\u2013S2.","DOI":"10.1017\/S1047951118000719"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1017\/S1047951106000291","article-title":"The nomenclature, definition and classification of hypoplastic left heart syndrome","volume":"16","author":"Tchervenkov","year":"2006","journal-title":"Cardiol. Young"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1017\/S1047951110001423","article-title":"The hybrid procedure for the borderline left ventricle","volume":"21","author":"Davis","year":"2011","journal-title":"Cardiol. Young"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.jacc.2012.07.041","article-title":"Staged left ventricular recruitment after single-ventricle palliation in patients with borderline left heart hypoplasia","volume":"60","author":"Emani","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1148\/radiology.169.2.2971985","article-title":"Estimation of human myocardial mass with MR imaging","volume":"169","author":"Katz","year":"1988","journal-title":"Radiology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/ehjci\/jev337","article-title":"Normal values of left ventricularmass and cardiac chamber volumes assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study","volume":"17","author":"Fuchs","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12880-019-0326-4","article-title":"Cardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy","volume":"19","author":"Gheorghe","year":"2019","journal-title":"BMC Med. 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