{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:11:12Z","timestamp":1760235072634,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The presence of adipocytes within thyroid glands is a rare finding seen in thyrolipoma, diffuse lipomatosis, or thyroid teratoma. Although some cases present with multinodular goiter or autoimmune thyroiditis, the exact cause has not yet been elucidated. Among reported cases, thyrolipomas mainly occur in females and usually present as a solitary lesion. However, a few reported cases had coexisting papillary thyroid carcinomas. Herein, we present a 51-year-old female with synchronous thyrolipoma (2.0 \u00d7 1.5 \u00d7 1.3 cm) and papillary thyroid carcinoma (0.7 \u00d7 0.6 \u00d7 0.6 cm) within the same thyroid lobe. She had diabetes mellitus and hypertension and complained of anterior neck enlargement and discomfort for three months. Thyroid sonography showed multiple hypoechoic nodules, one of which was heterogeneous and ill-defined. Fine needle aspirate cytology for the ill-defined nodule was suspicious for papillary thyroid carcinoma. She subsequently received radical thyroidectomy and neck lymph node dissection. Histopathologically, one thyrolipoma and one papillary thyroid carcinoma were identified in the right lobe of the thyroid gland without metastases of lymph nodes, while other nodules were multinodular goiter. Notably, thyrolipoma may not be simply an incidental finding but might coexist with thyroid carcinomas. A brief review of the pertinent literature of prior reports is also provided.<\/jats:p>","DOI":"10.3390\/diagnostics11081334","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T04:19:30Z","timestamp":1627273170000},"page":"1334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Thyrolipoma and Papillary Thyroid Carcinoma: A Rare but Significant Event"],"prefix":"10.3390","volume":"11","author":[{"given":"Mariya","family":"Kuk","sequence":"first","affiliation":[{"name":"Department of Pathology, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"},{"name":"Department of Pathology, McGill University, Montreal, QC H3A 0G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Jen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-2416","authenticated-orcid":false,"given":"Van-Hung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"},{"name":"Department of Pathology, McGill University, Montreal, QC H3A 0G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-0884","authenticated-orcid":false,"given":"Chien-Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan"},{"name":"Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4103\/0377-4929.162890","article-title":"Diffuse lipomatosis of the thyroid gland with papillary microcarcinoma: Report of a rare entity","volume":"58","author":"Nandyala","year":"2015","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1556\/650.2018.31017","article-title":"Az autoimmun thyreoiditis, a k\u00e9toldali papillaris pajzsmirigy-carcinoma, a nyaki thyreolipoma \u00e9s a diabetes mellitus egy\u00fcttes el\u0151fordul\u00e1sa","volume":"159","author":"Steiner","year":"2018","journal-title":"Orvosi. Hetilap."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1309\/AJCP84INGJUVTBME","article-title":"Thyroid Pathology Findings in Cowden Syndrome: A Clue for the Diagnosis of the PTEN Hamartoma Tumor Syndrome","volume":"144","author":"Fachal","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/dc.2840080514","article-title":"Lipomas of anterior neck simulating thyroid nodules: Diagnosis by fine-needle aspiration","volume":"8","author":"Butler","year":"1992","journal-title":"Diagn. Cytopathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1017\/S0022215100135832","article-title":"Adenoma of thyroid gland containing fat (thyrolipoma). Report of a case","volume":"110","author":"Laforga","year":"1996","journal-title":"J. Laryngol. Otol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/dc.2840070209","article-title":"Thyrolipoma: Diagnostic pitfalls in the cytologic diagnosis and review of the literature","volume":"7","author":"Rollins","year":"1991","journal-title":"Diagn. Cytopathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1089\/thy.2017.0500","article-title":"The 2017 Bethesda System for Reporting Thyroid Cytopathology","volume":"27","author":"Cibas","year":"2017","journal-title":"Thyroid"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1089\/thy.2018.0728","article-title":"Differences in Thyroid Nodule Cytology and Malignancy Risk Between Children and Adults","volume":"29","author":"Cherella","year":"2019","journal-title":"Thyroid"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/8\/1334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:34:50Z","timestamp":1760164490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/8\/1334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["diagnostics11081334"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11081334","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2021,7,26]]}}}