{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:13:47Z","timestamp":1760235227704,"version":"build-2065373602"},"reference-count":88,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p &lt; 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p &lt; 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine\/paracrine mechanism is not supported by our findings.<\/jats:p>","DOI":"10.3390\/diagnostics11081361","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:46Z","timestamp":1627555666000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GIST and Ghrelin: To Be or Not to Be?"],"prefix":"10.3390","volume":"11","author":[{"given":"Irene Alexandra","family":"Spiridon","sequence":"first","affiliation":[{"name":"Department of Morpho-Functional Sciences I\u2014Morphopathology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Strada Universit\u0103\u021bii 16, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-4133","authenticated-orcid":false,"given":"Delia Gabriela Apostol","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences I\u2014Morphopathology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Strada Universit\u0103\u021bii 16, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Eliza","family":"Giu\u0219c\u0103","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences I\u2014Morphopathology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Strada Universit\u0103\u021bii 16, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ferariu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Regional Institute of Oncology, Str. General Henri Mathias Berthelot 2-4, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-844X","authenticated-orcid":false,"given":"Iulia C\u0103t\u0103lina","family":"Ple\u015fca","sequence":"additional","affiliation":[{"name":"Science Research Department, Institute of Interdisciplinary Research, \u201cAlexandru Ioan Cuza\u201d University, Strada Lasc\u0103r Catargi 54, 700107 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina Draga","family":"C\u0103runtu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences I\u2014Histology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Strada Universit\u0103\u021bii 16, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.21037\/jgo.2018.08.20","article-title":"Gastrointestinal stromal tumors: A comprehensive review","volume":"10","author":"Parab","year":"2019","journal-title":"J. Gastrointest. 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