{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:32:21Z","timestamp":1779294741118,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Foundation for Scientific Research Grant","award":["OTKA K57061 and OTKA K112939"],"award-info":[{"award-number":["OTKA K57061 and OTKA K112939"]}]},{"name":"(Strat\u00e9giai K+F m\u0171helyek kiv\u00e1l\u00f3s\u00e1ga: A peptiderg szignaliz\u00e1ci\u00f3 komplexit\u00e1sa \u00e9s szerepe sziszt\u00e9m\u00e1s betegs\u00e9gekben grant","award":["PEPSYS GINOP-2.3.2-15-2016-00050"],"award-info":[{"award-number":["PEPSYS GINOP-2.3.2-15-2016-00050"]}]},{"name":"Thematic Excellence Program 2020 Institutional Excellence Sub-Programme of the Ministry for Innovation and Technology in Hungary, within the framework of the second thematic program of the University of P\u00e9cs","award":["Thematic Excellence Program 2020 Institutional Excellence Sub-Programme of the Ministry for Innovation and Technology in Hungary, within the framework of the second thematic program of the University of P\u00e9cs"],"award-info":[{"award-number":["Thematic Excellence Program 2020 Institutional Excellence Sub-Programme of the Ministry for Innovation and Technology in Hungary, within the framework of the second thematic program of the University of P\u00e9cs"]}]},{"name":"New National Excellence Program of the Ministry of the Human Capacities.","award":["\u00daNKP-21-4-II:"],"award-info":[{"award-number":["\u00daNKP-21-4-II:"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction: Nailfold video capillaroscopy (NVC) is a useful tool for measuring capillary density (CD) and capillary morphology parameters and is mainly used in systemic sclerosis (SSc). Objective: We aimed to assess the prevalence of an SSc pattern and CD in different connective tissue diseases (CTDs). Methods: NVC was performed on 268 patients with CTDs. Control groups consisted of 104 healthy volunteers (HVs) and 36 primary Raynaud\u2019s patients (PRPs). Results: Decreased CD was more prevalent in SSc, systemic lupus erythematosus (SLE), inflammatory myopathies (IIM), and overlap CTD patients compared with both controls. Average CD, the prevalence of decreased CD, and the prevalence of an SSc pattern did not differ significantly between SSc patients with (n = 39) and without (n = 50) overlap syndrome. An SSc pattern was significantly more prevalent in SLE (23%), SSc (82%), IIM (35%), and rheumatoid arthritis (17%) compared with both control groups. The prevalence of an elevated microangiopathy evaluation score (MES) was significantly higher in SLE, SSc, and IIM than in the HVs. Conclusion: The presence of another CTD in SSc did not influence CD or morphology. An SSc pattern may also be present in CTDs other than SSc. The MES is a useful instrument to distinguish between patients with CTDs and controls.<\/jats:p>","DOI":"10.3390\/diagnostics11091606","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:09:25Z","timestamp":1630933765000},"page":"1606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patients with Systemic Sclerosis with and without Overlap Syndrome Show Similar Microvascular Abnormalities"],"prefix":"10.3390","volume":"11","author":[{"given":"Gabriella","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Medical School, University of P\u00e9cs, Ak\u00e1c Street 1, 7362 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Czirj\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Medical School, University of P\u00e9cs, Ak\u00e1c Street 1, 7362 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-2918","authenticated-orcid":false,"given":"G\u00e1bor","family":"Kum\u00e1novics","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Medical School, University of P\u00e9cs, Ak\u00e1c Street 1, 7362 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"ref_1","first-page":"8","article-title":"Capillaroscopy 2016: New perspectives in systemic sclerosis","volume":"41","author":"Pizzorni","year":"2016","journal-title":"Acta Reum. 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