{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:20:23Z","timestamp":1760235623015,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>An age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4\u2032-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)\/computed Tomography (CT)providing cell proliferation imaging. A mass forming high 4DST uptake in the descending colon and focal moderate 4DST uptake in the sigmoid colon was confirmed, and that were proven pathologically as adenocarcinoma and moderate to severe type tubular adenoma, respectively. This is the first report to present that colorectal adenoma can be visualized by proliferation PET imaging and the degree of uptake may enable discrimination of colorectal adenoma from adenocarcinoma, based on pathological considerations.<\/jats:p>","DOI":"10.3390\/diagnostics11091658","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T10:31:34Z","timestamp":1631269894000},"page":"1658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell Proliferation PET Imaging with 4DST PET\/CT in Colorectal Adenocarcinoma and Adenoma"],"prefix":"10.3390","volume":"11","author":[{"given":"Ryogo","family":"Minamimoto","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo 1628655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Edogawa Hospital, Tokyo 1330052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1111\/j.1572-0241.2000.03434.x","article-title":"Polyp guideline: Diagnosis, treatment, and surveillance for patients with colorectal polyps. Practice Parameters Committee of the American College of Gastroenterology","volume":"95","author":"Bond","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/sj.bjc.6601007","article-title":"A case cohort study for the disease natural history of adenoma-carcinoma and de novo carcinoma and surveillance of colon and rectum after polypectomy: Implication for efficacy of colonoscopy","volume":"88","author":"Chen","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup","volume":"329","author":"Winawer","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1007\/s002590100645","article-title":"Evaluation of (pre-)malignant colonic abnormalities: Endoscopic validation of FDG-PET findings","volume":"28","author":"Drenth","year":"2001","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1148\/radiol.2302021685","article-title":"Detection of clinically unexpected malignant and premalignant tumors with whole-body FDG PET: Histopathologic comparison","volume":"230","author":"Agress","year":"2004","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12149-013-0797-2","article-title":"Detection of colorectal cancer and adenomas by FDG-PET cancer screening program: Results based on a nationwide Japanese survey","volume":"28","author":"Minamimoto","year":"2013","journal-title":"Ann. Nucl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/RLU.0b013e318239245d","article-title":"A stepwise approach using metabolic volume and SUVmax to differentiate malignancy and dysplasia from benign colonic uptakes on 18F-FDG PET\/CT","volume":"37","author":"Oh","year":"2012","journal-title":"Clin. Nuc. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s12149-013-0712-x","article-title":"Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake","volume":"27","author":"Minamimoto","year":"2013","journal-title":"Ann. Nucl. Med."},{"key":"ref_9","first-page":"1717","article-title":"Evaluation of 4\u2019-[methyl-14C] thiothymidine for in vivo DNA synthesis imaging","volume":"47","author":"Toyohara","year":"2006","journal-title":"J. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2967\/jnumed.111.095539","article-title":"4\u2019-[Methyl-11C]-Thiothymidine PET\/CT for Proliferation Imaging in Non-Small Cell Lung Cancer","volume":"53","author":"Minamimoto","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00261-015-0601-y","article-title":"Comparison of 11C-4DST and 18F-FDG PET\/CT imaging for advanced renal cell carcinoma: Preliminary study","volume":"41","author":"Minamimoto","year":"2016","journal-title":"Abdom. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s12149-019-01393-2","article-title":"4\u2032-[methyl-11C]-thiothymidine as a proliferation imaging tracer for detection of colorectal cancer: Comparison with 18F-FDG","volume":"33","author":"Fukuda","year":"2019","journal-title":"Ann. Nucl. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3906\/sag-1410-24","article-title":"Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography","volume":"46","author":"Uzman","year":"2016","journal-title":"Turk. J. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-019-5324-y","article-title":"Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: A meta analysis","volume":"19","author":"Luo","year":"2019","journal-title":"BMC Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Meyer, H.-J., Wienke, A., and Surov, A. (2019). Associations between GLUT expression and SUV values derived from FDG-PET in different tumors\u2014A systematic review and meta analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217781"},{"key":"ref_16","first-page":"16","article-title":"An immunohistochemical study of Ki-67 in colorectal adenoma","volume":"63","author":"Nagorni","year":"2009","journal-title":"Med. Arh."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3109\/00365521.2010.487915","article-title":"ER\u03b2 expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis","volume":"45","author":"Barone","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/(SICI)1097-0142(19980701)83:1<34::AID-CNCR5>3.0.CO;2-E","article-title":"GLUT1 glucose transporter expression in colorectal carcinoma: A marker for poor prognosis","volume":"83","author":"Haber","year":"1998","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00428-008-0578-9","article-title":"Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum","volume":"452","author":"Greijer","year":"2008","journal-title":"Virchows Arch."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/gutjnl-2011-300511","article-title":"Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression","volume":"61","author":"Jimenez","year":"2012","journal-title":"Gut"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/9\/1658\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:00:07Z","timestamp":1760166007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/9\/1658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,10]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["diagnostics11091658"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11091658","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2021,9,10]]}}}