{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:15:26Z","timestamp":1785179726287,"version":"3.55.0"},"reference-count":95,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The development of new capsules now allows endoscopic diagnosis in all segments of the gastrointestinal tract and comes with new needs for differentiated preparation regimens. Although the literature is steadily increasing, the results of the conducted trials on preparation are sometimes conflicting. The ingestion of simethicone before gastric and small bowel capsule endoscopy for prevention of air bubbles is established. The value of a lavage before small bowel capsule endoscopy (SBCE) is recommended, although not supported by all studies. Ingestion in the morning before the procedure seems useful for the improvement of mucosa visualization. Lavage after swallowing of the capsule seems to improve image quality, and in some studies also diagnostic yield. Prokinetics has been used with first generation capsules to shorten gastric transit time and increase the rate of complete small bowel visualization. With the massively prolonged battery capacity of the new generation small bowel capsules, prokinetics are only necessary in significantly delayed gastric emptying as documented by a real-time viewer. Lavage is crucial for an effective colon capsule or pan-intestinal capsule endoscopy. Mainly high or low volume polyethylene glycol (PEG) is used. Apart from achieving optimal cleanliness, propulsion of the capsule by ingested boosts is required to obtain a complete passage through the colon within the battery lifetime. Boosts with low volume sodium picosulfate (NaP) or diatrizoate (gastrografin) seem most effective, but potentially have more side effects than PEG. Future research is needed for more patient friendly but effective preparations, especially for colon capsule and pan-intestinal capsule endoscopy.<\/jats:p>","DOI":"10.3390\/diagnostics11091711","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T07:52:14Z","timestamp":1632124334000},"page":"1711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lavage, Simethicone, and Prokinetics\u2014What to Swallow with a Video Capsule"],"prefix":"10.3390","volume":"11","author":[{"given":"Martin","family":"Keuchel","sequence":"first","affiliation":[{"name":"Agaplesion Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Clinic for Internal Medicine, 21029 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niehls","family":"Kurniawan","sequence":"additional","affiliation":[{"name":"Agaplesion Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Clinic for Internal Medicine, 21029 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-8642","authenticated-orcid":false,"given":"Marc","family":"Bota","sequence":"additional","affiliation":[{"name":"Agaplesion Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Clinic for Internal Medicine, 21029 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Baltes","sequence":"additional","affiliation":[{"name":"Agaplesion Bethesda Krankenhaus Bergedorf, Academic Teaching Hospital of the University of Hamburg, Clinic for Internal Medicine, 21029 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/2050640619850365","article-title":"Performance measures for small-bowel endoscopy: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative","volume":"7","author":"Spada","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5946\/ce.2018.101","article-title":"Current and Future Use of Esophageal Capsule Endoscopy","volume":"51","author":"Park","year":"2018","journal-title":"Clin. Endosc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Keuchel, M., Hagenmueller, F., and Tajiri, H. (2014). Esophageal capsule endoscopy. Video Capsule Endoscopy: A Reference Guide and Atlas, Springer.","DOI":"10.1007\/978-3-662-44062-9"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-995645","article-title":"Detecting esophageal disease with second-generation capsule endoscopy: Initial evaluation of the PillCam ESO 2","volume":"40","author":"Gralnek","year":"2008","journal-title":"Endoscopy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vgie.2019.03.003","article-title":"Standardized examination procedure of magnetically controlled capsule endoscopy","volume":"4","author":"Jiang","year":"2019","journal-title":"VideoGIE"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.dld.2017.09.129","article-title":"Gastric preparation for magnetically controlled capsule endoscopy: A prospective, randomized single-blinded controlled trial","volume":"50","author":"Zhu","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s10620-018-5415-7","article-title":"Repetitive Position Change Improves Gastric Cleanliness for Magnetically Controlled Capsule Gastroscopy","volume":"64","author":"Wang","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2147\/CEG.S260906","article-title":"Poor quality of small bowel capsule endoscopy images has a significant negative effect in the diagnosis of small bowel malignancy","volume":"13","author":"Yung","year":"2020","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/00365521.2010.525714","article-title":"Systematic review and meta-analysis of randomized controlled trials of Simethicone for gastrointestinal endoscopic visibility","volume":"46","author":"Wu","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/a-0576-0566","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review","volume":"50","author":"Rondonotti","year":"2018","journal-title":"Endoscopy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","article-title":"Clinical Practice Guidelines for the Use of Video Capsule Endoscopy","volume":"152","author":"Enns","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"E1","article-title":"s2k guideline: Quality requirements for gastrointestinal endoscopy, awmf registry no. 021\u2013022","volume":"53","author":"Denzer","year":"2015","journal-title":"Z. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sey, M., Yan, B., McDonald, C., Segal, D., Friedland, J., Puka, K., and Jairath, V. (2021). A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249490"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0016-5107(04)00003-3","article-title":"Simethicone for small bowel preparation for capsule endoscopy: A systematic, single-blinded, controlled study","volume":"59","author":"Albert","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1055\/a-0573-1044","article-title":"Development and validation of an automated algorithm to evaluate the abundance of bubbles in small bowel capsule endoscopy","volume":"06","author":"Pietri","year":"2018","journal-title":"Endosc. Int. Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5946\/ce.2013.46.2.147","article-title":"Guidelines for Bowel Preparation before Video Capsule Endoscopy","volume":"46","author":"Song","year":"2013","journal-title":"Clin. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.gie.2013.06.026","article-title":"Wireless capsule endoscopy","volume":"78","author":"Committee","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3748\/wjg.14.1313","article-title":"Efficiency of bowel preparation for capsule endoscopy examination: A meta-analysis","volume":"14","author":"Niv","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ajg.2008.63","article-title":"Does Purgative Preparation Influence the Diagnostic Yield of Small Bowel Video Capsule Endoscopy?: A Meta-Analysis","volume":"104","author":"Rokkas","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1185\/03007995.2012.747953","article-title":"Meta-analysis: Efficacy of small bowel preparation for small bowel video capsule endoscopy","volume":"28","author":"Belsey","year":"2012","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/MEG.0b013e328365b9d4","article-title":"Should bowel preparation, antifoaming agents, or prokinetics be used before video capsule endoscopy? A systematic review and meta-analysis","volume":"26","author":"Kotwal","year":"2014","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7468728","DOI":"10.1155\/2017\/7468728","article-title":"Polyethylene Glycol for Small Bowel Capsule Endoscopy","volume":"2017","author":"Yang","year":"2017","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/17474124.2017.1359540","article-title":"Systematic review and meta-analysis: Is bowel preparation still necessary in small bowel capsule endoscopy?","volume":"11","author":"Yung","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1055\/s-0043-125207","article-title":"Meta-analysis of randomized controlled trials challenging the usefulness of purgative preparation before small-bowel video capsule endoscopy","volume":"50","author":"Gkolfakis","year":"2018","journal-title":"Endoscopy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1185\/03007995.2013.803055","article-title":"Consensus guidelines for the use of bowel preparation prior to colonic diagnostic procedures: Colonoscopy and small bowel video capsule endoscopy","volume":"29","author":"Pellise","year":"2013","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-0030-1256193","article-title":"Bowel cleansing for colonoscopy: Prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents","volume":"43","author":"Lawrance","year":"2011","journal-title":"Endoscopy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e8322","DOI":"10.1097\/MD.0000000000008322","article-title":"Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy","volume":"96","author":"Chen","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.dld.2019.04.014","article-title":"Bowel preparation for small bowel capsule endoscopy-the later, the better!","volume":"51","author":"Xavier","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_29","first-page":"261","article-title":"A case-control study demonstrates an improved visualization when capsule endoscopy is performed after preparation with polyethylene glycol and ascorbic acid","volume":"113","year":"2021","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000490942","article-title":"Clear Liquids versus Polyethylene Glycol Preparation for Video Capsule Endoscopy of the Small Bowel: A Randomized Controlled Trial","volume":"99","author":"Bahar","year":"2019","journal-title":"Digestion"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/03007995.2017.1308922","article-title":"Optimal use of polyethylene glycol for preparation of small bowel video capsule endoscopy: A network meta-analysis","volume":"33","author":"Wu","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/jgh.14899","article-title":"Low-dose and same day use of polyethylene glycol improves image of video capsule endoscopy: A multi-center randomized clinical trial","volume":"35","author":"Wu","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dld.2013.08.130","article-title":"Small bowel cleansing for capsule endoscopy in paediatric patients: A prospective randomized single-blind study","volume":"46","author":"Oliva","year":"2014","journal-title":"Dig. Liver Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1097\/MCG.0000000000000460","article-title":"Superiority of the split-dose peg regimen for small-bowel capsule endoscopy: A randomized controlled trial","volume":"50","author":"Carmo","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000323225","article-title":"Optimal Approach for Small Bowel Capsule Endoscopy Using Polyethylene Glycol and Metoclopramide with the Assistance of a Real-Time Viewer","volume":"84","author":"Hosono","year":"2011","journal-title":"Digestion"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3748\/wjg.v18.i15.1789","article-title":"Prospective controlled study on the effects of polyethylene glycol in capsule endoscopy","volume":"18","author":"Ito","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s10620-008-0292-0","article-title":"Ingesting 500 mL of Polyethylene Glycol Solution During Capsule Endoscopy Improves the Image Quality and Completion Rate to the Cecum","volume":"53","author":"Endo","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/2050640616665291","article-title":"A novel purgative protocol for capsule endoscopy of the small bowel produces better quality of visibility than 2 l of PEG: Timing is of the essence","volume":"5","author":"Adler","year":"2017","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1055\/s-2007-966943","article-title":"Diagnosis of small-bowel pathology using paired capsule endoscopy with two different devices: A randomized study","volume":"39","author":"Hartmann","year":"2007","journal-title":"Endoscopy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.1055\/a-1372-4051","article-title":"Scoring systems in clinical small-bowel capsule endoscopy: All you need to know!","volume":"9","author":"Rosa","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4253\/wjge.v8.i17.600","article-title":"Review of small-bowel cleansing scales in capsule endoscopy: A panoply of choices","volume":"8","author":"Ponte","year":"2016","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.gie.2008.04.016","article-title":"A validation study of 3 grading systems to evaluate small-bowel cleansing for wireless capsule endoscopy: A quantitative index, a qualitative evaluation, and an overall adequacy assessment","volume":"69","author":"Brotz","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101612","DOI":"10.1016\/j.clinre.2020.101612","article-title":"Prospective evaluation of third-generation small bowel capsule endoscopy videos by independent readers demonstrates poor reproducibility of cleanliness classifications","volume":"45","author":"Dray","year":"2021","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1055\/s-2007-966988","article-title":"Optimal preparation for video capsule endoscopy: A prospective, randomized, single-blind study","volume":"39","author":"Ouden","year":"2007","journal-title":"Endoscopy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/s-0030-1256228","article-title":"Description of a novel grading system to assess the quality of bowel preparation in video capsule endoscopy","volume":"43","author":"Mulder","year":"2011","journal-title":"Endoscopy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/den.12599","article-title":"Validated computed cleansing score for video capsule endoscopy","volume":"28","author":"Klein","year":"2016","journal-title":"Dig. Endosc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"709","DOI":"10.17235\/reed.2016.4366\/2016","article-title":"Validation of the computed assessment of cleansing score with the mirocam(r) system","volume":"108","author":"Ponte","year":"2016","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E944","DOI":"10.1055\/a-0918-5883","article-title":"Multi-criterion, automated, high-performance, rapid tool for assessing mucosal visualization quality of still images in small bowel capsule endoscopy","volume":"7","author":"Oumrani","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0016-5107(04)02462-9","article-title":"Complete small-bowel transit in patients undergoing capsule endoscopy: Determining factors and improvement with metoclopramide","volume":"61","author":"Selby","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.5754\/hge11081","article-title":"Intramuscular Injection of Metoclopramide Decreases the Gastric Transit Time and Does Not Increase the Complete Examination Rate of Capsule Endoscopy: A Prospective Randomized Controlled Trial","volume":"58","author":"Zhang","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.gie.2008.06.044","article-title":"Are bowel purgatives and prokinetics useful for small-bowel capsule endoscopy? A prospective randomized controlled study","volume":"69","author":"Postgate","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00228-017-2399-8","article-title":"Domperidone prolongs oral to duodenal transit time in video capsule endoscopy","volume":"74","author":"McFarlane","year":"2018","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"344","DOI":"10.21037\/tp-20-273","article-title":"Can domperidone decrease transit time of pediatric video capsule endoscopy? A randomized controlled trial","volume":"10","author":"Wu","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.3748\/wjg.14.2561","article-title":"Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study","volume":"14","author":"Niv","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Westerhof, J., Weersma, R.K., Hoedemaker, R.A., and Koornstra, J.J. (2014). Completion rate of small bowel capsule endoscopy is higher after erythromycin compared to domperidone. BMC Gastroenterol., 14.","DOI":"10.1186\/1471-230X-14-162"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5009\/gnl.2012.6.3.339","article-title":"Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate","volume":"6","author":"Ida","year":"2012","journal-title":"Gut Liver"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2696947","DOI":"10.1155\/2017\/2696947","article-title":"The Effect of Prucalopride on Small Bowel Transit Time in Hospitalized Patients Undergoing Capsule Endoscopy","volume":"2017","author":"Alsahafi","year":"2017","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/sjg.SJG_415_19","article-title":"The impact of inpatient capsule endoscopy on the need for therapeutic interventions in patients with obscure gastrointestinal bleeding","volume":"26","author":"Alsahafi","year":"2020","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"P176","DOI":"10.1016\/S0016-5107(04)00832-6","article-title":"Tegaserod Decreases Small Bowel Transit Times in Patients Undergoing Capsule Endoscopy","volume":"59","author":"Schmelkin","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000496350","article-title":"Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy","volume":"37","author":"Stein","year":"2019","journal-title":"Dig. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.gie.2009.04.045","article-title":"Lubiprostone neither decreases gastric and small-bowel transit time nor improves visualization of small bowel for capsule endoscopy: A double-blind, placebo-controlled study","volume":"70","author":"Hooks","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_62","unstructured":"Pascu, O. (2011). Effectiveness of daikenchuto, a traditional japanese herbal medicine, in accelerating capsule endoscopy transit time-a prospective pilot study. New Techniques in Gastrointestinal Endoscopy, InTech."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/gastro\/goz054","article-title":"Evaluating a combined bowel preparation for small-bowel capsule endoscopy: A prospective randomized-controlled study","volume":"8","author":"Hansel","year":"2020","journal-title":"Gastroenterol. Rep. (Oxf.)"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1586\/17434440.4.4.431","article-title":"Rapid Access Real-Time device and Rapid Access software: New tools in the armamentarium of capsule endoscopy","volume":"4","author":"Spada","year":"2007","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00535-007-2140-y","article-title":"Clinical impact of a newly developed capsule endoscope: Usefulness of a real-time image viewer for gastric transit abnormality","volume":"43","author":"Ogata","year":"2008","journal-title":"J. Gastroenterol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.gie.2007.04.011","article-title":"Initial experience of real-time capsule endoscopy in monitoring progress of the videocapsule through the upper GI tract","volume":"66","author":"Lai","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1440-1746.2011.06734.x","article-title":"Use of an external real-time image viewer coupled with prespecified actions enhanced the complete examinations for capsule endoscopy","volume":"26","author":"Shiotani","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4253\/wjge.v5.i12.595","article-title":"Finding the solution for incomplete small bowel capsule endoscopy","volume":"5","author":"Cotter","year":"2013","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.gie.2012.07.034","article-title":"Accuracy of automatic detection of small-bowel mucosa by second-generation colon capsule endoscopy","volume":"76","author":"Adler","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1056\/NEJMoa0806347","article-title":"Capsule Endoscopy versus Colonoscopy for the Detection of Polyps and Cancer","volume":"361","author":"Carretero","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kobaek-Larsen, M., Kroijer, R., Dyrvig, A.-K., Buijs, M.M., Steele, R.J.C., Qvist, N., and Baatrup, G. (2018). Back-to-back colon capsule endoscopy and optical colonoscopy in colorectal cancer screening individuals. Color. Dis., 20.","DOI":"10.1111\/codi.13965"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1055\/s-0031-1291717","article-title":"Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"44","author":"Spada","year":"2012","journal-title":"Endoscopy"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1055\/s-0031-1291611","article-title":"A pilot study evaluating a new low-volume colon cleansing procedure for capsule colonoscopy","volume":"44","author":"Hartmann","year":"2012","journal-title":"Endoscopy"},{"key":"ref_74","first-page":"312","article-title":"Preparations for colon capsule endoscopy. Prospective and randomized comparative study between two preparations for colon capsule endoscopy: Peg 2 liters + ascorbic acid versus peg 4 liters","volume":"106","author":"Belda","year":"2014","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.3748\/wjg.v24.i31.3556","article-title":"PillCamColon2 after incomplete colonoscopy-A prospective multicenter study","volume":"24","author":"Baltes","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MCG.0b013e3181dac04b","article-title":"Pillcam colon capsule endoscopy: A prospective, randomized trial comparing two regimens of preparation","volume":"45","author":"Spada","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/gutjnl-2013-306550","article-title":"Colon capsule versus ct colonography in patients with incomplete colonoscopy: A prospective, comparative trial","volume":"64","author":"Spada","year":"2015","journal-title":"Gut"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E659","DOI":"10.1055\/s-0034-1393075","article-title":"Gastrografin as an alternative booster to sodium phosphate in colon capsule endoscopy: Safety and efficacy pilot study","volume":"3","author":"Togashi","year":"2015","journal-title":"Endosc. Int. Open"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8615","DOI":"10.3748\/wjg.v23.i48.8615","article-title":"Multicenter, randomized study to optimize bowel preparation for colon capsule endoscopy","volume":"23","author":"Kastenberg","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.gastro.2015.01.025","article-title":"Accuracy of Capsule Colonoscopy in Detecting Colorectal Polyps in a Screening Population","volume":"148","author":"Rex","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1756283X16673556","article-title":"Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy","volume":"10","author":"Sato","year":"2017","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/den.13259","article-title":"Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy","volume":"31","author":"Ohmiya","year":"2019","journal-title":"Dig. Endosc."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Buijs, M.M., Kobaek-Larsen, M., Kaalby, L., and Baatrup, G. (2018). Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial. BMC Gastroenterol., 18.","DOI":"10.1186\/s12876-018-0824-9"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.gastrohep.2013.10.010","article-title":"One-day versus two-day cleansing for colon capsule endoscopy: A prospective randomized pilot study","volume":"37","author":"Ramos","year":"2014","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1093\/ibd\/izy125","article-title":"A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis","volume":"24","author":"Okabayashi","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.gie.2011.03.1125","article-title":"Second-generation colon capsule endoscopy compared with colonoscopy","volume":"74","author":"Spada","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0030-1255916","article-title":"A grading scale to evaluate colon cleansing for the PillCam COLON capsule: A reliability study","volume":"43","author":"Leighton","year":"2011","journal-title":"Endoscopy"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1756283X15586355","article-title":"Polyethylene glycol plus an oral sulfate solution as a bowel cleansing regimen for colon capsule endoscopy: A prospective, single-arm study in healthy volunteers","volume":"8","author":"Kashyap","year":"2015","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.cgh.2013.12.027","article-title":"Accuracy of Capsule Colonoscopy and Computed Tomographic Colonography in Individuals with Positive Results from the Fecal Occult Blood Test","volume":"12","author":"Rondonotti","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Bruining, D.H., Oliva, S., Fleisher, M.R., Fischer, M., Fletcher, J.G., and BLINK Study Group (2020). Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in crohn\u2019s disease: A multicentre, prospective study. BMJ Open Gastroenterol., 7.","DOI":"10.1136\/bmjgast-2019-000365"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3892\/etm.2017.4664","article-title":"Feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy","volume":"14","author":"Zhou","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3748\/wjg.v18.i17.2092","article-title":"New reduced volume preparation regimen in colon capsule endoscopy","volume":"18","author":"Kakugawa","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1055\/s-2006-944832","article-title":"Evaluation of the PillCam Colon capsule in the detection of colonic pathology: Results of the first multicenter, prospective, comparative study","volume":"38","author":"Eliakim","year":"2006","journal-title":"Endoscopy"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"E844","DOI":"10.1055\/a-0577-2897","article-title":"Development of a computed cleansing score to assess quality of bowel preparation in colon capsule endoscopy","volume":"6","author":"Becq","year":"2018","journal-title":"Endosc. Int. Open"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"E1044","DOI":"10.1055\/a-0627-7136","article-title":"Assessment of bowel cleansing quality in colon capsule endoscopy using machine learning: A pilot study","volume":"6","author":"Buijs","year":"2018","journal-title":"Endosc. Int. 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