{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:16:04Z","timestamp":1791375364063,"version":"4.3.1"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V110C-180"],"award-info":[{"award-number":["V110C-180"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans General Hospitals and University System of Taiwan Joint Research Program","award":["VGHUST110-G5-1-3"],"award-info":[{"award-number":["VGHUST110-G5-1-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Thalassemia and iron deficiency are the most common etiologies for microcytic anemia and there are indices discriminating both from common laboratory simple automatic counters. In this study a new classifier for discriminating thalassemia and non-thalassemia microcytic anemia was generated via combination of exciting indices with machine-learning techniques. A total of 350 Taiwanese adult patients whose anemia diagnosis, complete blood cell counts, and hemoglobin gene profiles were retrospectively reviewed. Thirteen prior established indices were applied to current cohort and the sensitivity, specificity, positive and negative predictive values were calculated. A support vector machine (SVM) with Monte-Carlo cross-validation procedure was adopted to generate the classifier. The performance of our classifier was compared with original indices by calculating the average classification error rate and area under the curve (AUC) for the sampled datasets. The performance of this SVM model showed average AUC of 0.76 and average error rate of 0.26, which surpassed all other indices. In conclusion, we developed a convenient tool for primary-care physicians when deferential diagnosis contains thalassemia for the Taiwanese adult population. This approach needs to be validated in other studies or bigger database.<\/jats:p>","DOI":"10.3390\/diagnostics11091725","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T07:52:14Z","timestamp":1632124334000},"page":"1725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The TVGH-NYCU Thal-Classifier: Development of a Machine-Learning Classifier for Differentiating Thalassemia and Non-Thalassemia Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-2370","authenticated-orcid":false,"given":"Yi-Kai","family":"Fu","sequence":"first","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueng-Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hsuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hsuan","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Shi","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hsuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-8322","authenticated-orcid":false,"given":"Po-Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jheng-You","family":"Lai","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyong-Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-4731","authenticated-orcid":false,"given":"Chun-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Yangming Campus, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fmolb.2020.00074","article-title":"Update in Laboratory Diagnosis of Thalassemia","volume":"7","author":"Munkongdee","year":"2020","journal-title":"Front. 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