{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:23:32Z","timestamp":1785000212519,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In recent years, a novel Doppler ultrasonography (US) modality\u2014superb microvascular imaging (SMI)\u2014has been presented as a reliable method to evaluate small vessel blood flow with minimised motion artefacts. In this review, we present the challenges of incorporating SMI in daily practice with detailed and comparable US images of a fingertip. The main focus of this paper is the discussion of all tested US techniques, artefacts, and practical challenges for evaluating Raynaud\u2019s syndrome in systemic sclerosis. Despite a few reports on SMI use in assessing nailfold capillaries, there is still a need for more evidence of its value and possibilities for its standardisation.<\/jats:p>","DOI":"10.3390\/diagnostics11101743","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T22:50:48Z","timestamp":1632351048000},"page":"1743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Promising Role of a Superb Microvascular Imaging Technique in the Evaluation of Raynaud\u2019s Syndrome in Systemic Sclerosis: Theory and Practical Challenges"],"prefix":"10.3390","volume":"11","author":[{"given":"Gabija","family":"Jasionyte","sequence":"first","affiliation":[{"name":"Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Seskute","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Rugiene","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania"},{"name":"Department of Experimental, Preventive and Clinical Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Butrimiene","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology, Orthopaedics Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/art.1780160506","article-title":"Patterns of Finger Capillary Abnormalities in Connective Tissue Disease by \u201cWide-Field\u201d Microscopy","volume":"16","author":"Maricq","year":"1973","journal-title":"Arthritis Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrrheum.2010.104","article-title":"Assessing Microvascular Changes in Systemic Sclerosis Diagnosis and Management","volume":"6","author":"Cutolo","year":"2010","journal-title":"Nat. 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Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/rheumatology\/kez374","article-title":"Progression of Nailfold Capillaroscopic Patterns and Correlation with Organ Involvement in Systemic Sclerosis: A 12 Year Study","volume":"59","author":"Sulli","year":"2020","journal-title":"Rheumatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.autrev.2017.05.019","article-title":"The Role of Nailfold Capillaroscopy in the Assessment of Internal Organ Involvement in Systemic Sclerosis: A Critical Review","volume":"16","author":"Soulaidopoulos","year":"2017","journal-title":"Autoimmun. 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