{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:47:24Z","timestamp":1773053244958,"version":"3.50.1"},"reference-count":92,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Musculoskeletal Australia","award":["PhD Scholarship"],"award-info":[{"award-number":["PhD Scholarship"]}]},{"name":"National Health and Medical Research Council \/ National Heart Foundation","award":["cofunded Postgraduate Scholarship"],"award-info":[{"award-number":["cofunded Postgraduate Scholarship"]}]},{"DOI":"10.13039\/501100001232","name":"RACP","doi-asserted-by":"publisher","award":["JJ Billings Scholarship"],"award-info":[{"award-number":["JJ Billings Scholarship"]}],"id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012087","name":"PSA","doi-asserted-by":"publisher","award":["Cardiovascular Scholarship"],"award-info":[{"award-number":["Cardiovascular Scholarship"]}],"id":[{"id":"10.13039\/100012087","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart Foundation","award":["Future Leadership Fellowship"],"award-info":[{"award-number":["Future Leadership Fellowship"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 1176538"],"award-info":[{"award-number":["GNT 1176538"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cardiac disease is a leading cause of death in systemic sclerosis (SSc) and sudden cardiac death (SCD) is thought to occur more commonly in SSc than in the general population. Diffuse myocardial fibrosis, myocarditis and ischaemic heart disease are all prevalent in SSc and can be reasonably hypothesised to contribute to an increased risk of SCD. Despite this, SCD remains a relatively understudied area of SSc with little understood about SSc-specific risk factors and opportunities for primary prevention. In this review, we present an overview of the possible mechanisms of SCD in SSc and our current understanding of how each of these mechanisms may contribute to cardiac death. This review highlights the need for a future research agenda that addresses the underlying epidemiology of SCD in SSc and identifies opportunities for intervention to modify the disease course of heart disease in SSc.<\/jats:p>","DOI":"10.3390\/diagnostics11101781","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:29:14Z","timestamp":1632832154000},"page":"1781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sudden Cardiac Death in Systemic Sclerosis: Diagnostics to Assess Risk and Inform Management"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-729X","authenticated-orcid":false,"given":"Laura","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Rheumatology, St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne at St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Paratz","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne at St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Department of Cardiology, St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Clinical Research Domain, Baker Heart and Diabetes Institute, 99 Commercial Road, Melbourne, VIC 3004, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Jewish General Hospital, McGill University, 3755 Chemin de la C\u00f4te-Sainte-Catherine, Montreal, QC H3T 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"La Gerche","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne at St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Department of Cardiology, St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Clinical Research Domain, Baker Heart and Diabetes Institute, 99 Commercial Road, Melbourne, VIC 3004, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne at St. Vincent\u2019s Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.semarthrit.2018.07.008","article-title":"Defining primary systemic sclerosis heart involvement: A scoping literature review","volume":"48","author":"Ross","year":"2019","journal-title":"Semin. 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