{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:24:29Z","timestamp":1760235869313,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies\/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorionic villi or amniotic fluid in the 2 centers of BCNatal in which a maternal saliva sample was used to establish its parental origin. Pathology studies were performed in products of conception and concordance between a partial hydatidiform mole diagnosis and the finding of a diandric triploidy was assessed. Results: among 46 fetal triploidies, found in 13 ongoing pregnancies and in 33 miscarriages, there were 26 (56%) diandric triploidies. Concordant molecular (diandric triploidy) and pathology results (partial mole) were achieved in 14 cases (54%), while in 6 cases (23%) pathology studies were normal, and in the remaining 6 cases (23%) pathology studies could not be performed because miscarriage was managed medically. Conclusions: diandric triploidy is associated with partial hydatidiform mole and its diagnosis is crucial to prevent the development of persistent trophoblastic disease. QF-PCR analysis in chorionic villi or amniotic fluid provides a more accurate diagnosis of the parental origin of triploidy than the classical pathology studies.<\/jats:p>","DOI":"10.3390\/diagnostics11101811","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T10:22:42Z","timestamp":1632997362000},"page":"1811","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Contribution of QF-PCR and Pathology Studies in the Diagnosis of Diandric Triploidy\/Partial Mole"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-036X","authenticated-orcid":false,"given":"Leticia","family":"Ben\u00edtez","sequence":"first","affiliation":[{"name":"BCNatal, Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic de Barcelona and Hospital Sant Joan de D\u00e9u, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Pauta","sequence":"additional","affiliation":[{"name":"BCNatal, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-0477","authenticated-orcid":false,"given":"C\u00e8lia","family":"Badenas","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Madrigal","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-093X","authenticated-orcid":false,"given":"Alfons","family":"Nadal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Department of Basic Clinical Practice, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Molecular Pathology of Inflammatory Conditions and Solid Tumors, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edda","family":"Marimon","sequence":"additional","affiliation":[{"name":"BCNatal, Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic de Barcelona and Hospital Sant Joan de D\u00e9u, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-4797","authenticated-orcid":false,"given":"Antoni","family":"Borrell","sequence":"additional","affiliation":[{"name":"BCNatal, Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic de Barcelona and Hospital Sant Joan de D\u00e9u, 08028 Barcelona, Spain"},{"name":"BCNatal, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1093\/hmg\/ddm243","article-title":"The origin of human aneuploidy: Where we have been, where we are going","volume":"16","author":"Hassold","year":"2007","journal-title":"Hum. 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