{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:07:05Z","timestamp":1790622425795,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: To characterize ocular surface temperature (OST) in healthy eyes and its association with systemic risk factors of cardiovascular and ischemic heart disease. Methods: This prospective cross-sectional study included consenting subjects who were examined at the Institute for Medical Screening in Sheba Medical Center. A Therm-App\u2122 thermal imaging camera (Opgal LTD, Israel) was used for OST acquisition, and the mean OST of the medial canthal, lateral canthal, and central cornea regions were measured. Room and body temperatures were also recorded. Past medical and ocular history as well as data from various clinical examinations performed at the same visit were obtained. Results: Thermographic images were obtained from 186 subjects, 150 of which were included in the final analysis. OST was significantly higher in the medial canthal, central cornea, and lateral canthal regions in people with a history of ischemic heart disease (p = 0.02, p = 0.02, and p = 0.03, respectively). There were no significant OST differences (ANOVA test) associated with the presence of hypertension, diabetes mellitus, or active smoking status. Conclusions: OST correlated positively with the presence of ischemic heart disease. This correlation, its pathophysiological base, and its clinical application warrants further investigation.<\/jats:p>","DOI":"10.3390\/diagnostics11101877","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T08:09:32Z","timestamp":1634026172000},"page":"1877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ocular Surface Temperature: Characterization in a Large Cohort of Healthy Human Eyes and Correlations to Systemic Cardiovascular Risk Factors"],"prefix":"10.3390","volume":"11","author":[{"given":"Gal Yaakov","family":"Cohen","sequence":"first","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-1005","authenticated-orcid":false,"given":"Gil","family":"Ben-David","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Department of Ophthalmology, Rabin Medical Center, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-1017","authenticated-orcid":false,"given":"Reut","family":"Singer","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Benyosef","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Shemesh","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Leshno","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"The Sheba Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Barkana","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Skaat","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Research Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cbpa.2016.02.022","article-title":"Infrared thermography: A non-invasive window into thermal physiology","volume":"202","author":"Tattersall","year":"2016","journal-title":"Comp. 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