{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:17:30Z","timestamp":1775665050829,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012283","name":"Chiayi Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6G0091, CORPG6G0092, CORPG6D0292, CORPG6K0131)"],"award-info":[{"award-number":["CORPG6G0091, CORPG6G0092, CORPG6D0292, CORPG6K0131)"]}],"id":[{"id":"10.13039\/501100012283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>(1) Background: We used four-dimensional phase-contrast magnetic resonance imaging (4D PC-MRI) to evaluate the impact of an endovascular aortic repair (TEVAR) on aortic dissection. (2) Methods: A total of 10 patients received 4D PC-MRI on a 1.5-T MR both before and after TEVAR. (3) Results: The aortas were repaired with either a GORE TAG Stent (Gore Medical; n = 7) or Zenith Dissection Endovascular Stent (Cook Medical; n = 3). TEVAR increased the forward flow volume of the true lumen (TL) (at the abdominal aorta, p = 0.047). TEVAR also reduced the regurgitant fraction in the TL at the descending aorta but increased it in the false lumen (FL). After TEVAR, the stroke distance increased in the TL (at descending and abdominal aorta, p = 0.018 and 0.015), indicating more effective blood transport per heartbeat. Post-stenting quantitative flow revealed that the reductions in stroke volume, backward flow volume, and absolute stroke volume were greater when covered stents were used than when bare stents were used in the FL of the descending aorta. Bare stents had a higher backward flow volume than covered stents did. (4) Conclusions: TEVAR increased the stroke volume in the TL and increased the regurgitant fraction in the FL in patients with aortic dissection.<\/jats:p>","DOI":"10.3390\/diagnostics11101912","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:13:32Z","timestamp":1634512412000},"page":"1912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Before and after Endovascular Aortic Repair in the Same Patients with Aortic Dissection: A Cohort Study of Four-Dimensional Phase-Contrast Magnetic Resonance Imaging"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-9919","authenticated-orcid":false,"given":"Chien-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Chia Yi Chang Gung Memorial Hospital, Putzu City 61363, Taiwan"},{"name":"Department of Diagnostic Radiology, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-3076","authenticated-orcid":false,"given":"Yueh-Fu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan"},{"name":"Department of Thoracic Medicine, Chang Gung University, College of Medicine, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hsi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan"},{"name":"Department of Thoracic Medicine, Chang Gung University, College of Medicine, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Yi","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Chia Yi Chang Gung Memorial Hospital, Putzu City 61363, Taiwan"},{"name":"Division of Thoracic and Cardiovascular Surgery, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Chia Yi Chang Gung Memorial Hospital, Putzu City 61363, Taiwan"},{"name":"Division of Thoracic and Cardiovascular Surgery, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-486X","authenticated-orcid":false,"given":"Yin-Chen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Chia Yi Chang Gung Memorial Hospital, Putzu City 61363, Taiwan"},{"name":"Department of Diagnostic Radiology, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-2571","authenticated-orcid":false,"given":"Bor-Shyh","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Imaging and Biomedical Photonics, National Yang Ming Chiao Tung University, Tainan 71150, Taiwan"},{"name":"Department of Medical Research, Chi-Mei Medical Center, Tainan 30010, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Kuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Chia Yi Chang Gung Memorial Hospital, Putzu City 61363, Taiwan"},{"name":"Division of Thoracic and Cardiovascular Surgery, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1016\/j.jtcvs.2010.07.062","article-title":"Acute aortic syndrome","volume":"140","author":"Lansman","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ejvs.2009.09.001","article-title":"Intramural Hematoma and Penetrating Ulcers: Indications to Endovascular Treatment","volume":"38","author":"Eggebrecht","year":"2009","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_3","first-page":"133","article-title":"Acute aortic syndromes: Definition, prognosis and treatment options","volume":"55","author":"Carpenter","year":"2014","journal-title":"J. Cardiovasc. Surg. (Torino)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/eurheartj\/ehx319","article-title":"Acute aortic syndromes: Diagnosis and management, an update","volume":"39","author":"Bossone","year":"2018","journal-title":"Eur. Hear. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jtcvs.2019.10.074","article-title":"Aortic growth and development of partial false lumen thrombosis are associated with late adverse events in type B aortic dissection","volume":"161","author":"Higashigaito","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5507\/bp.2016.060","article-title":"Acute aorta, overview of acute CT findings and endovascular treatment options","volume":"161","author":"Thomas","year":"2017","journal-title":"Biomed. Pap."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"20150825","DOI":"10.1259\/bjr.20150825","article-title":"MDCT evaluation of acute aortic syndrome (AAS)","volume":"89","author":"Valente","year":"2016","journal-title":"Br. J. Radiol."},{"key":"ref_8","first-page":"305","article-title":"Endovascular approach for acute aortic syndrome","volume":"51","author":"Russo","year":"2010","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3949\/ccjm.75.1.7","article-title":"CT imaging for acute aortic syndrome","volume":"75","author":"Smith","year":"2008","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Schieda, N., Blaichman, J.I., Costa, A.F., Glikstein, R., Hurrell, C., James, M., Maralani, P.J., Shabana, W., Tang, A., and Tsampalieros, A. (2018). Gadolinium-Based Contrast Agents in Kidney Disease: A Comprehensive Review and Clinical Practice Guideline Issued by the Canadian Association of Radiologists. Can. J. Kidney Heal. Dis., 5.","DOI":"10.1177\/2054358118778573"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s13244-015-0420-2","article-title":"Revisiting the risks of MRI with Gadolinium based contrast agents\u2014Review of literature and guidelines","volume":"6","author":"Khawaja","year":"2015","journal-title":"Insights Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.hjc.2017.12.001","article-title":"Magnetic resonance imaging is a safe technique in patients with prosthetic heart valves and coronary stents","volume":"60","author":"Karamitsos","year":"2019","journal-title":"Hell. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.athoracsur.2011.02.068","article-title":"Safety of Magnetic Resonance Imaging in Patients With Implanted Cardiac Prostheses and Metallic Cardiovascular Electronic Devices","volume":"91","author":"Baikoussis","year":"2011","journal-title":"Ann. Thorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jmri.20871","article-title":"Time-resolved 3D MR velocity mapping at 3T: Improved navigator-gated assessment of vascular anatomy and blood flow","volume":"25","author":"Markl","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/mrm.21778","article-title":"Quantitative 2D and 3D phase contrast MRI: Optimized analysis of blood flow and vessel wall parameters","volume":"60","author":"Stalder","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chen, C.-W., Tseng, Y.-H., Wong, M., Lin, Y.-H., Yang, T.-Y., Hsu, Y.-C., Lin, B.-S., and Huang, Y.-K. (2021). Using Non-Contrast MRA to Discriminate between Obstructive and Nonobstructive Venous Diseases of the Legs. Diagnostics, 11.","DOI":"10.3390\/diagnostics11081392"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/qims-20-670","article-title":"Aortic dissection assessment by 4D phase-contrast MRI with hemodynamic parameters: The impact of stent type","volume":"11","author":"Chen","year":"2021","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, C.-W., Tseng, Y.-H., Fang, Y.-F., Wong, M., Lin, Y.-H., and Huang, Y.-K. (2021). Superficial Venous Reflux Intervention Guided by Triggered Angiography Non-Contrast-Enhanced Sequence Magnetic Resonance Imaging: Different QFlow Pattern from Health Controls. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080751"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2214\/AJR.16.16995","article-title":"Phase-Contrast MRI CSF Flow Measurements for the Diagnosis of Normal-Pressure Hydrocephalus: Observer Agreement of Velocity Versus Volume Parameters","volume":"208","author":"Tawfik","year":"2017","journal-title":"Am. J. Roentgenol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Von Spiczak, J., Crelier, G., Giese, D., Kozerke, S., Maintz, D., and Bunck, A.C. (2015). Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139025"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jvs.2007.11.059","article-title":"Tear size and location impacts false lumen pressure in an ex vivo model of chronic type B aortic dissection","volume":"47","author":"Tsai","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jvs.2012.07.008","article-title":"An in vitro phantom study on the influence of tear size and configuration on the hemodynamics of the lumina in chronic type B aortic dissections","volume":"57","author":"Rudenick","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1016\/j.jvs.2012.07.061","article-title":"Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection","volume":"57","author":"Cheng","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ejvs.2016.01.006","article-title":"Persistent Intraluminal Pressure After Endovascular Stent Grafting for Type B Aortic Dissection","volume":"51","author":"Qing","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10237-015-0729-2","article-title":"Multi-modality image-based computational analysis of haemodynamics in aortic dissection","volume":"15","author":"Noorani","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rudenick, P.A., Segers, P., Pineda, V., Cu\u00e9llar, H., Garcia-Dorado, D., Evangelista, A., and Bijnens, B.H. (2017). False Lumen Flow Patterns and their Relation with Morphological and Biomechanical Characteristics of Chronic Aortic Dissections. Computational Model Compared with Magnetic Resonance Imaging Measurements. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170888"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jtcvs.2012.07.019","article-title":"Four-dimensional, flow-sensitive magnetic resonance imaging of blood flow patterns in thoracic aortic dissections","volume":"145","author":"Markl","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jvs.2011.11.005","article-title":"A new imaging method for assessment of aortic dissection using four-dimensional phase contrast magnetic resonance imaging","volume":"55","author":"Clough","year":"2012","journal-title":"J. Vasc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1148\/rg.23si035507","article-title":"CT in Nontraumatic Acute Thoracic Aortic Disease: Typical and Atypical Features and Complications","volume":"23","author":"Andreu","year":"2003","journal-title":"Radiographics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10140-002-0249-0","article-title":"Chest CT scanning for clinical suspected thoracic aortic dissection: Beware the alternate diagnosis","volume":"9","author":"Thoongsuwan","year":"2002","journal-title":"Emerg. Radiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.rcl.2009.09.006","article-title":"MDCT Evaluation of Acute Aortic Syndrome","volume":"48","author":"Yoo","year":"2010","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1148\/rg.302095104","article-title":"Multidetector CT of Aortic Dissection: A Pictorial Review","volume":"30","author":"McMahon","year":"2010","journal-title":"Radiographics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1517\/17425250902873796","article-title":"Toxicity of MRI and CT contrast agents","volume":"5","author":"Hasebroock","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1038\/s41598-019-48946-z","article-title":"Feasibility study of using one-tenth mSv radiation dose in young children chest CT with 80 kVp and model-based iterative reconstruction","volume":"9","author":"Sun","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kataria, B., Alth\u00e9n, J.N., Smedby, \u00d6., Persson, A., S\u00f6kjer, H., and Sandborg, M. (2019). Image quality and pathology assessment in CT Urography: When is the low-dose series sufficient?. BMC Med Imaging, 19.","DOI":"10.1186\/s12880-019-0363-z"},{"key":"ref_36","first-page":"62","article-title":"Magnetic resonance angiography of the origins of the supraaortic arteries: Comparison of single and double volume acquisition 3D time of flight","volume":"23","author":"Carriero","year":"1996","journal-title":"J. Neuroradiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.187.3.8497608","article-title":"Atherosclerotic occlusive disease of the lower extremity: Prospective evaluation with two-dimensional time-of-flight MR angiography","volume":"187","author":"Yucel","year":"1993","journal-title":"Radiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jvs.2011.05.022","article-title":"A new method for quantification of false lumen thrombosis in aortic dissection using magnetic resonance imaging and a blood pool contrast agent","volume":"54","author":"Clough","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1055\/a-0647-2021","article-title":"4D-Flow MRI: Technique and Applications","volume":"190","author":"Huber","year":"2018","journal-title":"R\u00f6Fo-Fortschr. Geb. R\u00f6ntgenstrahlen Bildgeb. Verfahr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1038\/s41598-018-27249-9","article-title":"Quantitative Study of Abdominal Blood Flow Patterns in Patients with Aortic Dissection by 4-Dimensional Flow MRI","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/icvts\/ivy271","article-title":"Four-dimensional flow magnetic resonance imaging analysis before and after thoracic endovascular aortic repair of chronic type B aortic dissection","volume":"28","author":"Takei","year":"2018","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/jmri.27431","article-title":"Reproducibility of Aorta Segmentation on 4D Flow MRI in Healthy Volunteers","volume":"53","author":"Juffermans","year":"2021","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jmri.27432","article-title":"Editorial for Reproducibility of Aorta Segmentation on 4D Flow MRI in Healthy Volunteers","volume":"53","author":"Wentland","year":"2021","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12968-021-00741-4","article-title":"False lumen pressure estimation in type B aortic dissection using 4D flow cardiovascular magnetic resonance: Comparisons with aortic growth","volume":"23","author":"Marlevi","year":"2021","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jtcvs.2018.06.092","article-title":"Retrograde flow in the false lumen: Marker of a false lumen under stress?","volume":"157","author":"Burris","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ejcts\/ezz343","article-title":"False lumen ejection fraction predicts growth in type B aortic dissection: Preliminary results","volume":"57","author":"Burris","year":"2020","journal-title":"Eur. J. Cardio-Thorac. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/10\/1912\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:15:48Z","timestamp":1760166948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/10\/1912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["diagnostics11101912"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11101912","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}