{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:30:22Z","timestamp":1777901422107,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Acute pancreatitis is an unpredictable disease affecting the pancreas and it is characterized by a wide range of symptoms and modified lab tests, thus there is a continuing struggle to classify this disease and to find risk factors associated with a worse outcome. The main objective of this study was to identify the risk factors associated with the fatal outcome of the intensive care unit\u2019s patients diagnosed and admitted for severe acute pancreatitis, the secondary objective was to investigate the prediction value for the death of different inflammatory markers at the time of their admission to the hospital. This retrospective study included all the patients with a diagnosis of acute pancreatitis admitted to the Intensive Care Unit of the Emergency County Hospital Timisoara between 1 January 2016 and 31 May 2021. The study included 53 patients diagnosed with severe acute pancreatitis, out of which 21 (39.6%) survived and 32 (60.4%) died. For the neutrophils\/lymphocytes ratio, a cut-off value of 12.4 was found. When analyzing age, we found out that age above 52 years old can predict mortality, and for the platelets\/lymphocytes ratio, a cut-off value of 127 was found. Combining the three factors we get a new model for predicting mortality, with an increased performance, AUROC = 0.95, p &lt; 0.001. Multiple persistent organ failure, age over 50, higher values of C reactive protein, and surgery were risk factors for death in the patients with severe acute pancreatitis admitted to the intensive care unit. The model design from the neutrophils\/lymphocytes ratio, platelets\/lymphocytes ratio, and age proved to be the best in predicting mortality in severe acute pancreatitis.<\/jats:p>","DOI":"10.3390\/diagnostics11112013","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"2013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Monitoring Approach of Fatality Risk Factors for Patients with Severe Acute Pancreatitis Admitted to the Intensive Care Unit. A Retrospective, Monocentric Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Tudorel","family":"Mihoc","sequence":"first","affiliation":[{"name":"Department X, Surgical Emergencies Clinic, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-3910","authenticated-orcid":false,"given":"Cristi","family":"Tarta","sequence":"additional","affiliation":[{"name":"Department X, 2nd Surgical Clinic, Researching Future Chirurgie 2, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian","family":"Duta","sequence":"additional","affiliation":[{"name":"Department X, 2nd Surgical Clinic, Researching Future Chirurgie 2, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Lupusoru","sequence":"additional","affiliation":[{"name":"Department VII, Gastroenterology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department of Functional Sciences, Centre for Modeling Biological Systems and Data Analysis, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Dancu","sequence":"additional","affiliation":[{"name":"Department VII, Gastroenterology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Anca","family":"Oprescu-Macovei","sequence":"additional","affiliation":[{"name":"Gastroenterology, Emergency Hospital Prof. Dr. Agripa Ionescu, UMF Carol Davila, 011356 Bucure\u0219ti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadeus","family":"Dobrescu","sequence":"additional","affiliation":[{"name":"Department X, 2nd Surgical Clinic, Researching Future Chirurgie 2, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulger","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department X, 2nd Surgical Clinic, Researching Future Chirurgie 2, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012: Revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.0007-1323.2001.02025.x","article-title":"Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis","volume":"89","author":"Buter","year":"2002","journal-title":"Br. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/SLA.0b013e318256f778","article-title":"Determinant-based classification of acute pancreatitis severity: An international multidisciplinary consultation","volume":"256","author":"Dellinger","year":"2012","journal-title":"Ann Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00006676-200104000-00008","article-title":"Early severe acute pancreatitis: Characteristics of a new subgroup","volume":"22","author":"Isenmann","year":"2001","journal-title":"Pancreas"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4103\/JLP.JLP_82_19","article-title":"Predictive values of neutrophil-lymphocyte ratio as an early indicator for severe acute pancreatitis in the emergency department patients","volume":"11","author":"Park","year":"2019","journal-title":"J. Lab. Physicians"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.3748\/wjg.v23.i21.3883","article-title":"Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis","volume":"23","author":"Jeon","year":"2017","journal-title":"World J. 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Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MPA.0b013e31815acb2c","article-title":"Persistent early organ failure: Defining the high-risk group of patients with severe acute pancreatitis?","volume":"36","author":"Lytras","year":"2008","journal-title":"Pancreas"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/gutjnl-2017-314657","article-title":"Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis","volume":"68","author":"Schepers","year":"2018","journal-title":"Gut"},{"key":"ref_15","first-page":"246","article-title":"Mortality assessment in patients with severe acute pancreatitis: A comparative study of specific and general severity indices","volume":"24","author":"Macedo","year":"2012","journal-title":"Rev. Bras. Ter. 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Gastroenterol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2013\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:23:03Z","timestamp":1760167383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["diagnostics11112013"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11112013","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]}}}