{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:56:58Z","timestamp":1773471418069,"version":"3.50.1"},"reference-count":12,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: The demonstration of a rare case of bilateral diffuse uveal melanocytic proliferation (BDUMP) due to a lung carcinoma with unusual dermal lesions. Case description: A 76-year-old man with painless bilateral vision loss revealed leopard or giraffe spot chorioretinopathy and bilateral serous retinal detachment. Ultrasound biomicroscopy revealed uveal swelling expanding into the anterior chamber angle. Dermal and mucosal lesions were present on the lip, breast, groin, scrotum, and penis. Screening analyses revealed a non-small cell lung carcinoma. Conclusions: The diagnosis of BDUMP, a rare paraneoplastic syndrome, was made. The ophthalmological diagnosis led to screening investigations and revealed the underlying malignant disease. Uncommonly, multiple dermal and mucosal lesions could be detected and were analyzed histopathologically.<\/jats:p>","DOI":"10.3390\/diagnostics11112052","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T10:33:09Z","timestamp":1636108389000},"page":"2052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare Case of Bilateral Diffuse Uveal Melanocytic Proliferation with Dermal and Mucosal Hyperpigmentations"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-2963","authenticated-orcid":false,"given":"Michelle","family":"Prasuhn","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-8964","authenticated-orcid":false,"given":"Vinodh","family":"Kakkassery","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdy","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-0607","authenticated-orcid":false,"given":"Felix","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.survophthal.2012.09.001","article-title":"Paraneoplastic and Non-Paraneoplastic Retinopathy and Optic Neuropathy: Evaluation and Management","volume":"58","author":"Rahimy","year":"2013","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archopht.1990.01070060075053","article-title":"Bilateral Diffuse Uveal Melanocytic Proliferation in Patients with Occult Carcinoma","volume":"108","author":"Gass","year":"1990","journal-title":"Arch. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/eye.2013.131","article-title":"Dermal and Conjunctival Melanocytic Proliferations in Diffuse Uveal Melanocytic Proliferation","volume":"27","author":"Pulido","year":"2013","journal-title":"Eye"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archopht.121.11.1637","article-title":"Uveal and Cutaneous Involvement in Paraneoplastic Melanocytic Proliferation","volume":"121","author":"Singh","year":"2003","journal-title":"Arch. 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Available online: http:\/\/leitlinienprogramm-onkologie.de\/Lungenkarzinom.98.0.html."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2052\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:26:29Z","timestamp":1760167589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["diagnostics11112052"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11112052","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]}}}