{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:11:09Z","timestamp":1791231069527,"version":"4.1.0"},"reference-count":8,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We describe the case of a 45-year-old woman with an unusual presentation of metastatic ovarian cancer. The patient presented to the oncological clinic with a three-week history of skin rash on the right breast. She underwent a chest and abdomen CT scan, which showed skin thickening of the right breast, right pleural effusion and bilateral cystic ovarian masses. Biopsy of a left ovarian lesion by diagnostic laparoscopy revealed the presence of ovarian serous carcinoma. Biopsy of the breast skin lesion revealed the presence of carcinomatous lymphangitis and immunohistochemistry documented the ovarian origin.<\/jats:p>","DOI":"10.3390\/diagnostics11112106","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:48:36Z","timestamp":1636922916000},"page":"2106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Breast Carcinomatous Lymphangitis as an Unusual Presentation of Ovarian Cancer"],"prefix":"10.3390","volume":"11","author":[{"given":"Barbara","family":"Muoio","sequence":"first","affiliation":[{"name":"Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6501 Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-780X","authenticated-orcid":false,"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[{"name":"Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6501 Bellinzona, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera italiana, 6900 Lugano, Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Migliora","sequence":"additional","affiliation":[{"name":"Cantonal Institute of Pathology, Ente Ospedaliero Cantonale, 6600 Locarno, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Del Grande","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6501 Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100606","DOI":"10.1016\/j.gore.2020.100606","article-title":"Intestinal lymphangitis carcinomatosa related to ovarian cancer: Case report and review of the literature","volume":"33","author":"Cruz","year":"2020","journal-title":"Gynecol. Oncol. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1806-37132007000500018","article-title":"Carcinomatous lymphangitis as the initial manifestation of ovarian adenocarcinoma","volume":"33","author":"Martynychen","year":"2007","journal-title":"J. Bras. Pneumol."},{"key":"ref_3","first-page":"979","article-title":"Lymphangite carcinomateuse [Carcinomatous lymphangitis]","volume":"28","author":"Hominal","year":"1999","journal-title":"Presse Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.clinimag.2019.08.002","article-title":"Lymphangitic spread of invasive lobular carcinoma to the contralateral breast","volume":"58","author":"Burns","year":"2019","journal-title":"Clin. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gore.2018.07.006","article-title":"Cutaneous lymphangitic carcinomatosis: A rare metastasis from cervical cancer","volume":"26","author":"Burbano","year":"2018","journal-title":"Gynecol. Oncol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lebeck Lee, C., Zwerner, J., O\u2019Brian, B., and Eng, C. (2021). Cutaneous Lymphangitic Carcinomatosis as the First Sign of Recurrent Malignancy in a Patient With a History of Rectal Adenocarcinoma. Clin. Colorectal. Cancer.","DOI":"10.1016\/j.clcc.2021.09.010"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.amjmed.2015.04.007","article-title":"Getting the whole picture: Lymphangitic carcinomatosis","volume":"128","author":"Biswas","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Massollo, M., Fiz, F., Bottoni, G., Ugolini, M., Paparo, F., Puppo, C., Provinciali, N., Iacozzi, M., Altrinetti, V., and Cistaro, A. (2021). To Enhance or Not to Enhance? The Role of Contrast Medium 18F-FDG PET\/CT in Recurrent Ovarian Carcinomas. Medicina, 57.","DOI":"10.3390\/medicina57060561"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2106\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:30:09Z","timestamp":1760167809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/11\/2106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,14]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["diagnostics11112106"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11112106","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,14]]}}}