{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:40Z","timestamp":1787027920178,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The small bowel is the longest organ within the gastrointestinal tract. The emergence of small bowel capsule endoscopy (SBCE) over the last 20 years has revolutionized the investigation and diagnosis of small bowel pathology. Its utility as a non-invasive and well-tolerated procedure, which can be performed in an outpatient setting, has made it a valuable diagnostic tool. The indications for SBCE include obscure gastrointestinal bleeding, small bowel Crohn\u2019s disease, and, less frequently for screening in polyposis syndromes, celiac disease, or other small bowel pathology. Currently, there are several small bowel capsules on the market from different manufacturers; however, they share many technological features. The European Society of Gastrointestinal Endoscopy (ESGE) only recently developed a set of key quality indicators to guide quality standards in this area. Many of the technical aspects of capsule endoscopy still feature a degree of uncertainty in terms of optimal performance. Incomplete studies due to slow transit through the bowel, poor imaging secondary to poor preparation, and the risk of capsule retention remain frustrations in its clinical utility. Capsule review is a time-consuming process; however, artificial intelligence and machine learning offer opportunities to improve this. This narrative review examines our current standing in a number of these aspects and the potential to further the application of SBCE in order to maximize its diagnostic utility.<\/jats:p>","DOI":"10.3390\/diagnostics11112139","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T08:53:56Z","timestamp":1637225636000},"page":"2139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Small-Bowel Capsule Endoscopy\u2014Optimizing Capsule Endoscopy in Clinical Practice"],"prefix":"10.3390","volume":"11","author":[{"given":"Fintan","family":"O\u2019Hara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tallaght University Hospital, D24 NR0A Dublin, Ireland"},{"name":"TAGG Research Centre, School of Medicine, Trinity College, D24 NR0A Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tallaght University Hospital, D24 NR0A Dublin, Ireland"},{"name":"TAGG Research Centre, School of Medicine, Trinity College, D24 NR0A Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/35013140","article-title":"Wireless capsule endoscopy","volume":"405","author":"Iddan","year":"2000","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-0034-1391855","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline","volume":"47","author":"Pennazio","year":"2015","journal-title":"Endoscopy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1055\/a-0889-9586","article-title":"Performance measures for small-bowel endoscopy: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative","volume":"51","author":"Spada","year":"2019","journal-title":"Endoscopy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. 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