{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:34:01Z","timestamp":1760236441564,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant fund by the Korea government (MSIT)","award":["2018R1C1B5086585"],"award-info":[{"award-number":["2018R1C1B5086585"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>IgG4-related disease is a rare immune-mediated disease that can involve many organs in the body. The lymph node is also where IgG4-related diseases occur, but its histological structure is different from that of other organs. For this reason, pathologists have difficulty diagnosing IgG4-related lymphadenopathy. If there were specific imaging findings of IgG4-related lymphadenopathy, it would be of great help to pathologists. A 64-year-old male visited our hospital with right ankle pain. On physical examination, the right lower extremity showed severe swelling with wound dehiscence, and infection was suspected. On CT (128-MDCT, Somatom Definition Flash, Siemens Healthcare) taken at the lower extremity, multiple enlarged lymph nodes were incidentally noted in the right inguinal area. On ultrasonography, a \u201cstarry night sign\u201d resembling hyperechoic follicles was observed in the enlarged lymph node. A core needle biopsy was performed, and IgG4-related lymphadenopathy was diagnosed. Laboratory examination showed hypergammaglobulinemia with marked elevated serum IgG4, corresponding to IgG4-related disease. Chest and abdominal imaging were evaluated, but there was no extranodal IgG4-related disease. IgG4-related lymphadenopathy showed a very unique ultrasonography imaging finding. The cortex was filled with diffusely scattered hyperechoic foci and some bright foci gathered to form a follicle. This imaging finding may help diagnose IgG4-related lymphadenopathy.<\/jats:p>","DOI":"10.3390\/diagnostics11122213","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T01:49:58Z","timestamp":1638150598000},"page":"2213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unique Ultrasonographic Findings of Isolated IgG4-Related Lymphadenopathy"],"prefix":"10.3390","volume":"11","author":[{"given":"Jae Sung","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Radiology, Ajou University School of Medicine, Suwon 16449, Korea"},{"name":"Musculoskeletal Imaging Laboratory, Ajou University Medical Center, Suwon 16449, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seoyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5276-4446","authenticated-orcid":false,"given":"Kyu Yun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeonbuk National University Medical School, Jeonju 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54907, Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"Igg4-Related Disease","volume":"385","author":"Kamisawa","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1148\/rg.357150066","article-title":"IgG4-related Disease from Head to Toe","volume":"35","year":"2015","journal-title":"Radiographics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"W276","DOI":"10.2214\/AJR.11.8321","article-title":"Systemic IgG4-Related Sclerosing Disease: Spectrum of Imaging Findings and Differential Diagnosis","volume":"199","author":"Horger","year":"2012","journal-title":"Am. 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