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Optical Coherence Tomography (OCT) is currently the gold standard for assessing individuals for initial AMD diagnosis. In this paper, we look at how OCT imaging can be used to diagnose AMD. Our main aim is to examine and compare automated computer-aided diagnostic (CAD) systems for diagnosing and grading of AMD. We provide a brief summary, outlining the main aspects of performance assessment and providing a basis for current research in AMD diagnosis. As a result, the only viable alternative is to prevent AMD and stop both this devastating eye condition and unwanted visual impairment. On the other hand, the grading of AMD is very important in order to detect early AMD and prevent patients from reaching advanced AMD disease. In light of this, we explore the remaining issues with automated systems for AMD detection based on OCT imaging, as well as potential directions for diagnosis and monitoring systems based on OCT imaging and telemedicine applications.<\/jats:p>","DOI":"10.3390\/diagnostics11122313","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:52:32Z","timestamp":1639086752000},"page":"2313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Role of Optical Coherence Tomography Imaging in Predicting Progression of Age-Related Macular Disease: A Survey"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-9709","authenticated-orcid":false,"given":"Mohamed","family":"Elsharkawy","sequence":"first","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-418X","authenticated-orcid":false,"given":"Mostafa","family":"Elrazzaz","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-6698","authenticated-orcid":false,"given":"Mohammed","family":"Ghazal","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering Department, College of Engineering, Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-5263","authenticated-orcid":false,"given":"Marah","family":"Alhalabi","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering Department, College of Engineering, Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-3416","authenticated-orcid":false,"given":"Ahmed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-9699","authenticated-orcid":false,"given":"Ali","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"El-Daydamony","sequence":"additional","affiliation":[{"name":"Faculty of Computers and Information, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Atwan","sequence":"additional","affiliation":[{"name":"Faculty of Computers and Information, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis","family":"Thanos","sequence":"additional","affiliation":[{"name":"Legacy Devers Eye Institute, Portland, OR 97210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal Singh","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruprasad","family":"Giridharan","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-1323","authenticated-orcid":false,"given":"Ayman","family":"El-Baz","sequence":"additional","affiliation":[{"name":"Bioengineering Department, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1001\/jama.291.15.1900","article-title":"Age-Related Macular Degeneration Is the Leading Cause of Blindness\u2026","volume":"291","author":"Bressler","year":"2004","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1076\/opep.11.2.67.28158","article-title":"2002 global update of available data on visual impairment: A compilation of population-based prevalence studies","volume":"11","author":"Pascolini","year":"2004","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1167\/iovs.16-20541","article-title":"Automated staging of age-related macular degeneration using optical coherence tomography","volume":"58","author":"Venhuizen","year":"2017","journal-title":"Investig. 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