{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:37:39Z","timestamp":1760236659304,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Non-arteritic anterior ischemic optic neuropathy (NA-AION) is considered the most frequent type of acute optic neuropathy. A 61-year-old woman presented with a NA-AION in her right eye within 24 h following an airplane flight. One year later, after driving for 10 days with a daily accumulated altitude of 1500 m, she developed a NA-AION in her left eye. Systemic disorders were investigated, and cerebral small vessel disease was observed via cranial computed tomography. An inadequate response to hypoxia, in a patient with individual susceptibility, could lead to reduced blood supply to the optic nerve head, which could represent an underlying cause of NA-AION.<\/jats:p>","DOI":"10.3390\/diagnostics11122325","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T08:17:58Z","timestamp":1639124278000},"page":"2325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-Simultaneous Bilateral Ischemic Optic Neuropathy Related to High Altitude and Airplane Flight in a Patient with Cerebral Small Vessel Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-5565","authenticated-orcid":false,"given":"Ana","family":"Boned-Murillo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, CP 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Esteban-Floria","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, CP 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), CP 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireya","family":"Martinez-Velez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, CP 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mateo Gabas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, CP 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-2555","authenticated-orcid":false,"given":"Francisco Javier","family":"Ascaso Puyuelo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, CP 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), CP 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","first-page":"88","article-title":"Non-arteritic anterior ischaemic optic neuropathy (NA-AION): Outcome for visual acuity and visual field defects, the Singapore scene 2","volume":"53","author":"Cullen","year":"2012","journal-title":"Singap. 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