{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:47:44Z","timestamp":1790790464332,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The primary imaging modality for the diagnosis of patent ductus arteriosus (PDA) is echocardiography. However, CT may be the technique on which an incidental PDA is first recognized because of the increasing number of chest CT scans performed for a variety of causes. Identification of PDA on CT may lead to earlier closure using a PDA occluder device. Immediate identification of incidental PDA is important, but a high rate of missed diagnosis of PDA has been reported due to its small size and anatomic location. In addition, echocardiography may overlook the presence of even a large PDA due to decrease in the amount of shunting through the PDA caused by high pulmonary artery pressures. This review provides the basic CT anatomy and clinical perspective of PDA, and discusses the role of CT in the evaluation of PDA as well as methods to avoid overlooking a small PDA on CT.<\/jats:p>","DOI":"10.3390\/diagnostics11122394","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T20:41:55Z","timestamp":1639946515000},"page":"2394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Patent Ductus Arteriosus in Adults with Special Focus on Role of CT"],"prefix":"10.3390","volume":"11","author":[{"given":"Soo Jeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology, CHA University Kangnam Medical Ceneter, Seoul 06135, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Min","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHA University Bundang Medical Ceneter, Seongnam 13497, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHA University Bundang Medical Ceneter, Seongnam 13497, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/j.semperi.2011.09.025","article-title":"The patent ductus arteriosus in term infants, children, and adults","volume":"36","author":"Schneider","year":"2012","journal-title":"Semin. Perinatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13244-019-0693-y","article-title":"Significant incidental cardiac disease on thoracic CT: What the general radiologist needs to know","volume":"10","author":"Krueger","year":"2019","journal-title":"Insights Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/0002-8703(94)90415-4","article-title":"Clinically silent patent ductus arteriosus","volume":"127","author":"Lloyd","year":"1994","journal-title":"Am. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1161\/CIRCULATIONAHA.105.592063","article-title":"Patent ductus arteriosus","volume":"114","author":"Schneider","year":"2006","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1148\/rg.23si035503","article-title":"Cardiovascular shunts: MR imaging evaluation","volume":"23","author":"Wang","year":"2003","journal-title":"Radiographics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2214\/ajr.181.3.1810749","article-title":"Morphologic assessment of patent ductus arteriosus in adults using retrospectively ECG-gated multidetector CT","volume":"181","author":"Marshall","year":"2003","journal-title":"Am. J. Roentgenol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.acvd.2010.06.006","article-title":"The ductus arteriosus: Physiology, regulation, and functional and congenital anomalies","volume":"104","author":"Gournay","year":"2011","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0002-9149(89)90064-7","article-title":"Angiographic classification of the isolated, persistently patent ductus arteriosus and implications for percutaneous catheter occlusion","volume":"63","author":"Krichenko","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/tomography7030025","article-title":"High Rate of False Negative Diagnosis of Silent Patent Ductus Arteriosus on the Chest CT with 3 mm Slice-Thickness, Suggesting the Need for Analysis with Thinner Slice Thickness","volume":"7","author":"Lee","year":"2021","journal-title":"Tomography"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/j.ro.2011.12.003","article-title":"Simple cardiac shunts in adults","volume":"47","author":"Berko","year":"2012","journal-title":"Semin. Roentgenol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.2214\/ajr.184.6.01841924","article-title":"Incidental finding on MDCT of patent ductus arteriosus: Use of CT and MRI to assess clinical importance","volume":"184","author":"Goitein","year":"2005","journal-title":"Am. J. Roentgenol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ihj.2017.08.001","article-title":"Contemporary outcomes of percutaneous closure of patent ductus arteriosus in adolescents and adults","volume":"70","author":"P","year":"2018","journal-title":"Indian Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00276-020-02620-6","article-title":"High prevalence of a linear valve-like structure on CT at the pulmonary artery terminus of patent ductus arteriosus in adult patients, mimicking endarteritis","volume":"43","author":"Son","year":"2021","journal-title":"Surg. Radiol. Anat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4070\/kcj.2019.0289","article-title":"Computed Tomography Diagnosis of Patent Ductus Arteriosus Endarteritis and Septic Pulmonary Embolism","volume":"50","author":"Lee","year":"2020","journal-title":"Korean Circ. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/000331970405500115","article-title":"Pulmonary endarteritis and subsequent embolization to the lung as a complication of a patent ductus arteriosus--a case report","volume":"55","author":"Bilge","year":"2004","journal-title":"Angiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/chd.12830","article-title":"Ductus arteriosus-associated infective endarteritis: Lessons from the past, future perspective","volume":"14","author":"Callegari","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"774","DOI":"10.5152\/AnatolJCardiol.2021.36156","article-title":"Echocardiographic findings in patent ductus arteriosus-associated infective endarteritis","volume":"25","year":"2021","journal-title":"Anatol. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2169\/internalmedicine.46.0215","article-title":"Pulmonary endarteritis and subsequent pulmonary embolism associated with clinically silent patent ductus arteriosus","volume":"46","author":"Onji","year":"2007","journal-title":"Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/01.CIR.90.5.2525","article-title":"Endocarditis risk of the USCI PDA umbrella for transcatheter closure of patent ductus arteriosus","volume":"90","author":"Latson","year":"1994","journal-title":"Circulation"},{"key":"ref_20","first-page":"33","article-title":"Surgical management of patent ductus arteriosus. A review of 413 cases","volume":"34","author":"Ghani","year":"1989","journal-title":"J. R. Coll. Surg. Edinb."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0003-4975(96)00962-9","article-title":"The role of surgical ligation of patent ductus arteriosus in the era of the Rashkind device","volume":"63","author":"Galal","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"ref_22","first-page":"147","article-title":"Transcatheter closure of PDA in premature babies less than 2 kg","volume":"17","author":"Narin","year":"2017","journal-title":"Anatol. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"558256","DOI":"10.3389\/fped.2020.558256","article-title":"Transcatheter Closure of Patent Ductus Arteriosus in Infants With Weight Under 1,500 Grams","volume":"8","author":"Fraisse","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.acvd.2014.01.008","article-title":"Transcatheter closure of patent ductus arteriosus: Past, present and future","volume":"107","author":"Baruteau","year":"2014","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ccd.22393","article-title":"Trans-catheter closure of patent ductus arteriosus-What is the best device?","volume":"76","author":"Ghasemi","year":"2010","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9149(92)90514-Y","article-title":"Percutaneous closure of the small (less than 2.5 mm) patent ductus arteriosus using coil embolization","volume":"69","author":"Cambier","year":"1992","journal-title":"Am. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/chd.12708","article-title":"PDA: To treat or not to treat","volume":"14","author":"Sankar","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_28","first-page":"1","article-title":"Trans-catheter closure of large PDA in adult patients with Amplatzer device: Case series","volume":"8","author":"Khajali","year":"2021","journal-title":"Cardiol. Young"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1002\/ccd.28002","article-title":"Percutaneous PDA closure with Amplatzer AVP ll and ADO ll AS devices","volume":"93","author":"Lucas","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/ccd.26856","article-title":"Closure of very large PDA with pulmonary hypertension: Initial clinical case-series with the new Occlutech PDA occluder","volume":"89","author":"Lehner","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1760-2734(06)70039-X","article-title":"Catheter closure of patent ductus arteriosus in dogs: Variation in ductal size requires different techniques","volume":"5","author":"Glaus","year":"2003","journal-title":"J. Vet. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1540-8183.2001.tb00719.x","article-title":"Transcatheter PDA closure: Equipment and technique","volume":"14","author":"Grifka","year":"2001","journal-title":"J. Interv. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/chd.12704","article-title":"Percutaneous closure of the patent uctus arteriosus: Opportunities moving forward","volume":"14","author":"Mitchell","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0735-1097(98)00013-8","article-title":"Catheter closure of moderate- to large-sized patent ductus arteriosus using the new Amplatzer duct occluder: Immediate and short-term results","volume":"31","author":"Masura","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ccd.27995","article-title":"Results of the combined U.S. multicenter postapproval study of the Nit-Occlud PDA device for percutaneous closure of patent ductus arteriosus","volume":"93","author":"Kobayashi","year":"2019","journal-title":"Catheter. Cardiovasc. 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