{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:10:00Z","timestamp":1760609400990,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Albert Bruppacher Foundation, Zurich","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Bayer (Switzerland)","award":["Swiss RetinAward 2017"],"award-info":[{"award-number":["Swiss RetinAward 2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Transcatheter aortic valve implantation (TAVI) is an alternative to open heart surgery in the treatment of symptomatic aortic valve stenosis, which is often the treatment of choice in elderly and frail patients. It carries a risk of embolic complications in the whole cerebral vascular bed, which includes the retinal vasculature. The main objective was the evaluation of retinal emboli visible on optical coherence tomography angiography (OCTA) following TAVI. This is a prospective, single center, observational study enrolling consecutive patients over two years. Patients were assessed pre- and post-TAVI. Twenty-eight patients were included in the final analysis, 82.1% were male, median age was 79.5 (range 52\u201388), median BCVA was 82.5 letters (range 75\u201393). Eight patients (28.6%) presented new capillary dropout lesions in their post-TAVI OCTA scans. There was no statistically significant change in BCVA. Quantitative analysis of macular or peripapillary OCTA parameters did not show any statistically significant difference in pre- and post-intervention. In conclusion, capillary dropout lesions could frequently be found in patients after TAVI. Quantitative measurements of macular and peripapillary flow remained stable, possibly indicating effective ocular blood flow regulation within the range of left ventricular ejection fraction in our cohort.<\/jats:p>","DOI":"10.3390\/diagnostics11122399","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T08:43:32Z","timestamp":1639989812000},"page":"2399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of Retinal Capillary Dropout after Transcatheter Aortic Valve Implantation by Optical Coherence Tomography Angiography"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9005-347X","authenticated-orcid":false,"given":"Jeanne","family":"Gunzinger","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burbuqe","family":"Ibrahimi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Baur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-1805","authenticated-orcid":false,"given":"Maximilian","family":"Wiest","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Piccirelli","sequence":"additional","affiliation":[{"name":"Department of Information Technology and Electrical Engineering, ETH Zurich, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Pangalu","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-7650","authenticated-orcid":false,"given":"Dominik","family":"Straumann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Nietlispach","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"},{"name":"Heartcenter im Park, Hirslanden Clinic Im Park, 8027 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igal","family":"Moarof","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital Baden, 5404 Baden, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-1774","authenticated-orcid":false,"given":"Sandrine","family":"Zweifel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Zurich, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1161\/CIRCULATIONAHA.112.001091","article-title":"Histopathology of embolic debris captured during transcatheter aortic valve replacement","volume":"127","author":"Schipper","year":"2013","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kapadia, S., Agarwal, S., Miller, D.C., Webb, J.G., Mack, M., Ellis, S., Herrmann, H.C., Pichard, A.D., Tuzcu, E.M., and Svensson, L.G. 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