{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:07:57Z","timestamp":1767704877425,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Deep neck infection (DNI) is a serious disease of deep neck spaces that can lead to morbidities and mortality. Acute epiglottitis (AE) is a severe infection of the epiglottis, which can lead to airway obstruction. However, there have been no studies of risk factors in patients with concurrent DNI and AE. This study was performed to investigate this issue. A total of 502 subjects with DNI were enrolled in the study between June 2016 and August 2021. Among these patients, 30 had concurrent DNI and AE. The relevant clinical variables were assessed. In a univariate analysis, involvement of the parapharyngeal space (OR = 21.50, 95% CI: 2.905\u2013158.7, p &lt; 0.001) and involvement of the submandibular space (OR = 2.064, 95% CI: 0.961\u20134.434, p &lt; 0.001) were significant risk factors for concurrent DNI and AE. In a multivariate analysis, involvement of the parapharyngeal space (OR = 23.69, 95% CI: 3.187\u2013175.4, p = 0.002) and involvement of the submandibular space (OR = 2.465, 95% CI: 1.131\u20135.375, p &lt; 0.023) were independent risk factors for patients with concurrent DNI and AE. There were no differences in pathogens, therapeutic managements (tracheostomy, intubation, surgical drainage), or hospital staying period between the 30 patients with concurrent DNI and AE and the 472 patients with DNI alone (all p &gt; 0.05). However, we believe it is significant that DNI and AE are concurrent because both DNI and AE potentially cause airway obstruction, and concurrence of these two diseases make airway protection more difficult. The infections in critical spaces may cause the coincidence of these two diseases. Involvement of the parapharyngeal space and involvement of the submandibular space were independent risk factors associated with concurrent DNI and AE. There were no differences in pathogens between the concurrent DNI and AE group and the DNI alone group.<\/jats:p>","DOI":"10.3390\/diagnostics12010029","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:40:21Z","timestamp":1640295621000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Factors Affecting Patients with Concurrent Deep Neck Infection and Acute Epiglottitis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-527X","authenticated-orcid":false,"given":"Chia-Ying","family":"Ho","sequence":"first","affiliation":[{"name":"Center for Traditional Chinese Medicine, Division of Chinese Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chien","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, New Taipei Municipal TuCheng Hospital, New Taipei City 236, Taiwan"},{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shy-Chyi","family":"Chin","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-4009","authenticated-orcid":false,"given":"Shih-Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00405-019-05742-9","article-title":"Deep neck space infections: An upward trend and changing characteristics","volume":"277","author":"Velhonoja","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1007\/s00405-017-4694-5","article-title":"Comparison of intubation and tracheotomy in patients with deep neck infection","volume":"274","author":"Tapiovaara","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0145561319877281","article-title":"The Factors Contributing to Efficiency in Surgical Management of Purulent Infections of Deep Neck Spaces","volume":"100","author":"Rzepakowska","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000093095","article-title":"Deep neck infections: A constant challenge","volume":"68","author":"Marchiori","year":"2006","journal-title":"ORL"},{"key":"ref_5","first-page":"E2275","article-title":"Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description","volume":"38","year":"2016","journal-title":"Head Neck"},{"key":"ref_6","first-page":"149","article-title":"Two cases of deep neck infection with esophageal perforation","volume":"26","author":"Aizawa","year":"2013","journal-title":"J.-STAGE"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tsai, Y.T., Huang, E.I., Chang, G.H., Tsai, M.S., Hsu, C.M., Yang, Y.H., Lin, M.H., Liu, C.Y., and Li, H.Y. (2018). Risk of acute epiglottitis in patients with preexisting diabetes mellitus: A population-based case-control study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199036"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jclinane.2014.05.003","article-title":"Difficult airway management in a patient with combined severe deep neck abscess and acute epiglottitis with abscess","volume":"26","author":"Komasawa","year":"2014","journal-title":"J. Clin. Anesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.anl.2010.06.004","article-title":"Four cases of acute epiglottitis with a peritonsillar abscess","volume":"38","author":"Ito","year":"2011","journal-title":"Auris Nasus Larynx"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IDR.S3554","article-title":"Deep neck abscess: An analysis of microbial etiology and the effectiveness of antibiotics","volume":"1","author":"Yang","year":"2008","journal-title":"Infect. Drug Resist."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0196-0709(00)85019-X","article-title":"Deep neck infections in diabetic patients","volume":"21","author":"Chen","year":"2000","journal-title":"Am. J. Otolaryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.otc.2008.01.002","article-title":"Deep neck infection","volume":"41","author":"Vieira","year":"2008","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00004728-198308000-00006","article-title":"Computed tomography of the parapharyngeal space","volume":"7","author":"Unger","year":"1983","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.2214\/ajr.177.6.1771465","article-title":"Imaging of parapharyngeal space lesions: Focus on the prestyloid compartment","volume":"177","author":"Shin","year":"2001","journal-title":"Am. J. Roentgenol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13244-018-0615-4","article-title":"Imaging of the sublingual and submandibular spaces","volume":"9","author":"Patel","year":"2018","journal-title":"Insights Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jmii.2015.08.020","article-title":"Deep neck infections in children","volume":"50","author":"Huang","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1017\/S0022215100119036","article-title":"Ossification of the epiglottis","volume":"106","author":"Milroy","year":"1992","journal-title":"J. Laryngol. Otol."},{"key":"ref_18","first-page":"187","article-title":"Paraglottic and Pre-epiglottic Space Abscess in Adults: Report of Two Cases","volume":"32","author":"Sideris","year":"2020","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.anorl.2020.12.001","article-title":"Intubation decision criteria in adult epiglottitis","volume":"138","author":"Pineau","year":"2021","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, S.L., Young, C.K., Tsai, T.Y., Chien, H.T., Kang, C.J., Liao, C.T., and Huang, S.F. (2021). Factors Affecting the Necessity of Tracheostomy in Patients with Deep Neck Infection. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091536"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2344\/anpr-66-04-08","article-title":"Medical Management of Epiglottitis","volume":"67","author":"Dowdy","year":"2020","journal-title":"Anesth. Prog."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chen, S.L., Young, C.K., Liao, C.T., Tsai, T.Y., Kang, C.J., and Huang, S.F. (2021). Parotid Space, a Different Space from Other Deep Neck Infection Spaces. Microorganisms, 9.","DOI":"10.3390\/microorganisms9112361"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/archotol.127.6.650","article-title":"Streptococcus milleri: An organism for head and neck infections and abscess","volume":"127","author":"Han","year":"2001","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_24","first-page":"4630809","article-title":"Streptococcus constellatus Causing Empyema and Sepsis, Necessitating Early Surgical Decortication","volume":"2020","author":"Chrastek","year":"2020","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.1038\/s41598-020-65977-z","article-title":"Clinical Characteristics of Infections Caused by Streptococcus anginosus Group","volume":"10","author":"Jiang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/clinids\/10.2.257","article-title":"Occurrence and pathogenicity of the Streptococcus milleri group","volume":"10","author":"Gossling","year":"1988","journal-title":"Rev. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/00207713-41-1-1","article-title":"Emended descriptions and recognition of Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus as distinct species","volume":"41","author":"Whiley","year":"1991","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1100\/tsw.2007.240","article-title":"Streptococcus constellatus and Prevotella bivia penile abscess","volume":"7","author":"Nalmas","year":"2007","journal-title":"Sci. World J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1128\/AAC.45.5.1511-1514.2001","article-title":"Antibiotic susceptibilities of genetically characterized Streptococcus milleri group strains","volume":"45","author":"Tracy","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/lary.21083","article-title":"Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: Evolving principles in diagnosis and management","volume":"120","author":"Guardiani","year":"2010","journal-title":"Laryngoscope"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/1\/29\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:52:29Z","timestamp":1760169149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/1\/29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["diagnostics12010029"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12010029","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2021,12,23]]}}}