{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:55:25Z","timestamp":1778936125170,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: We evaluated the prognostic value of Sarcopenia, low precardial adipose-tissue (PAT), and high tumor-volume in the outcome of surgically-treated pleural mesothelioma (PM). Methods: From 2005 to 2020, consecutive surgically-treated PM-patients having a pre-operative computed tomography (CT) scan were retrospectively included. Sarcopenia was assessed by CT-based parameters measured at the level of the fifth thoracic vertebra (TH5) by excluding fatty-infiltration based on CT-attenuation. The findings were stratified for gender, and a threshold of the 33rd percentile was set to define sarcopenia. Additionally, tumor volume as well as PAT were measured. The findings were correlated with progression-free survival and long-term mortality. Results: Two-hundred-seventy-eight PM-patients (252 male; 70.2 \u00b1 9 years) were included. The mean progression-free survival was 18.6 \u00b1 12.2 months, and the mean survival time was 23.3 \u00b1 24 months. Progression was associated with chronic obstructive pulmonary disease (COPD) (p = &lt;0.001), tumor-stage (p = 0.001), and type of surgery (p = 0.026). Three-year mortality was associated with higher patient age (p = 0.005), presence of COPD (p &lt; 0.001), higher tumor-stage (p = 0.015), and higher tumor-volume (p &lt; 0.001). Kaplan-Meier statistics showed that sarcopenic patients have a higher three-year mortality (p = 0.002). While there was a negative correlation of progression-free survival and mortality with tumor volume (r = 0.281, p = 0.001 and r = \u22120.240, p &lt; 0.001; respectively), a correlation with PAT could only be shown for epithelioid PM (p = 0.040). Conclusions: Sarcopenia as well as tumor volume are associated with long-term mortality in surgically treated PM-patients. Further, while there was a negative correlation of progression-free survival and mortality with tumor volume, a correlation with PAT could only be shown for epithelioid PM.<\/jats:p>","DOI":"10.3390\/diagnostics12010099","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:51:50Z","timestamp":1641250310000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sarcopenia, Precardial Adipose Tissue and High Tumor Volume as Outcome Predictors in Surgically Treated Pleural Mesothelioma"],"prefix":"10.3390","volume":"12","author":[{"given":"Oliver Guido","family":"Verhoek","sequence":"first","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Jungblut","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Lauk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"},{"name":"Department of Thoracic Surgery, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-5676","authenticated-orcid":false,"given":"Christian","family":"Bl\u00fcthgen","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-9040","authenticated-orcid":false,"given":"Isabelle","family":"Opitz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"},{"name":"Department of Thoracic Surgery, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6619","authenticated-orcid":false,"given":"Thomas","family":"Frauenfelder","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Martini","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, R\u00e4mistrasse 100, 8091 Zurich, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, R\u00e4mistrasse 71, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Committee BTSS of C (2007). 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