{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:56:06Z","timestamp":1787064966716,"version":"build-2736575974"},"reference-count":12,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditions (bronchiectasis, exocrine pancreatic insufficiency, chronic multidrug resistant Pseudomonas aeruginosa colonization, nasal polyposis, chronic sinusitis, ventricular extrasystoles and multiple drug allergies), who presented with an acute episode of productive cough, and was confirmed with moderate COVID-19 based on positive RT-PCR for SARS-CoV-2 and lung imaging showing isolated foci of interstitial pneumonia. Intravenous treatment with the monoclonal antibody cocktail casirivimab and imdevimab was administered. The evolution was favorable, with rapid remission of the inflammatory syndrome and gradual decrease of cough, without progression to severe or critical COVID-19, but with complications such as repeated hemoptysis, which was due to the patient\u2019s underlying conditions, and which required close monitoring for timely adjustment of the patient\u2019s chronic treatment.<\/jats:p>","DOI":"10.3390\/diagnostics12010137","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T03:46:27Z","timestamp":1641527187000},"page":"137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["First Case of COVID-19 Treated with Monoclonal Anti-Spike Antibodies in a Patient with Cystic Fibrosis in Romania"],"prefix":"10.3390","volume":"12","author":[{"given":"Iustina Violeta","family":"Stan","sequence":"first","affiliation":[{"name":"National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-5365","authenticated-orcid":false,"given":"Victor Daniel","family":"Miron","sequence":"additional","affiliation":[{"name":"National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Alexandra","family":"Vangheli","sequence":"additional","affiliation":[{"name":"National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-3784","authenticated-orcid":false,"given":"Radu Marian","family":"Gheorghiu","sequence":"additional","affiliation":[{"name":"National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Streinu-Cercel","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, 021105 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-4070","authenticated-orcid":false,"given":"Oana","family":"S\u0103ndulescu","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, 021105 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-6797","authenticated-orcid":false,"given":"Mihai","family":"Craiu","sequence":"additional","affiliation":[{"name":"National Institute for Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, 020395 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106062","DOI":"10.1016\/j.rmed.2020.106062","article-title":"Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey","volume":"170","year":"2020","journal-title":"Respir. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mathew, H.R., Choi, M.Y., Parkins, M.D., and Fritzler, M.J. (2021). Systematic review: Cystic fibrosis in the SARS-CoV-2\/COVID-19 pandemic. BMC Pulm. Med., 21.","DOI":"10.1186\/s12890-021-01528-0"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/j.jcf.2021.05.003","article-title":"Risk factors for cystic fibrosis arthropathy: Data from the German cystic fibrosis registry","volume":"20","author":"Grehn","year":"2021","journal-title":"J. Cyst. Fibros."},{"key":"ref_4","first-page":"1","article-title":"Clinical course and risk factors for severe COVID-19 among Italian patients with cystic fibrosis: A study within the Italian Cystic Fibrosis Society","volume":"49","author":"Colombo","year":"2021","journal-title":"Infection"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1183\/09031936.00196314","article-title":"Future trends in cystic fibrosis demography in 34 European countries","volume":"46","author":"Burgel","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.clinthera.2021.08.009","article-title":"Safety, Virologic Efficacy, and Pharmacokinetics of CT-P59, a Neutralizing Monoclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Protein: Two Randomized, Placebo-Controlled, Phase I Studies in Healthy Individuals and Patients with Mild SARS-CoV-2 Infection","volume":"43","author":"Kim","year":"2021","journal-title":"Clin. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJMoa2035002","article-title":"REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with COVID-19","volume":"384","author":"Weinreich","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1007\/s40265-021-01620-z","article-title":"Casirivimab\/Imdevimab: First Approval","volume":"81","author":"Deeks","year":"2021","journal-title":"Drugs"},{"key":"ref_9","first-page":"e11132","article-title":"Cardiac Adverse Events with Remdesivir in COVID-19 Infection","volume":"12","author":"Gupta","year":"2020","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1093\/cid\/ciaa954","article-title":"Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19","volume":"73","author":"Somers","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","first-page":"e9218","article-title":"H1N1 Influenza Virus in Patients with Cystic Fibrosis: A Literature Review Examining Both Disease Entities and Their Association in Light of the 2009 Pandemic","volume":"12","author":"Wiltshire","year":"2020","journal-title":"Cureus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/MCP.0000000000000823","article-title":"COVID-19 outcomes in people with cystic fibrosis","volume":"27","author":"Burgel","year":"2021","journal-title":"Curr. Opin. Pulm. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/1\/137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:27:01Z","timestamp":1760362021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/1\/137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["diagnostics12010137"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12010137","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]}}}