{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:22:31Z","timestamp":1783340551392,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Linkou Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG3L0031"],"award-info":[{"award-number":["CORPG3L0031"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We aimed to survey whether the timing of neodymium:yttrium\u2013aluminum\u2013garnet (Nd:YAG) laser capsulotomy would alter the corneal endothelial morphology and density. A retrospective cohort study was conducted, and 48 patients with unilateral posterior capsular opacity (PCO) and Nd:YAG laser capsulotomy performance were enrolled. The participants were divided into the early Nd:YAG group (timing \u2264 12 months, n = 20) and late Nd:YAG group (timing &gt; 12 months, n= 28) depending on elapsed months between phacoemulsification and Nd:YAG laser capsulotomy. Endothelial cell density (ECD), coefficient of variant (CV), hexagonality (HEX), and central corneal thickness (CCT) between the two groups were collected. A generalized estimate equation was conducted to evaluate the corneal endothelial parameters between the two groups with an adjusted odds ratio (aOR) and 95% confidence interval (CI). The CDVA was improved after treatment in both groups (both p &lt; 0.001). Chronically, ECD in the early group was significantly decreased one week after treatment (2221.50 \u00b1 327.73\/mm2 vs. 2441.55 \u00b1 321.80\/mm2, p &lt; 0.001), which recovered to 2369.95 \u00b1 76.37\/mm2 four weeks after the treatment but was still lower than the preoperative status (p &lt; 0.001). In addition, the HEX percentage showed a significant reduction at four weeks after treatment (p = 0.028). The ECD in the early group was significantly lower than that in the late group (aOR: 0.167, 95% CI: 0.079\u20130.356, p = 0.003) in both week 1 (p &lt; 0.001) and week 4 (p = 0.004) after laser treatment. In conclusion, the early application of Nd:YAG laser capsulotomy within one year after cataract surgery may be the reason for postoperative ECD decrement without known etiology.<\/jats:p>","DOI":"10.3390\/diagnostics12010150","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:29:26Z","timestamp":1641760166000},"page":"150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Corneal Endothelial Changes Following Early Capsulotomy Using Neodymium:Yttrium\u2013Aluminum\u2013Garnet Laser"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-7878","authenticated-orcid":false,"given":"Hung-Chi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Department of Medicine, College of Medicine, Chang Gung University, Linkou 333423, Taiwan"},{"name":"Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-0488","authenticated-orcid":false,"given":"Chia-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 50093, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-8717","authenticated-orcid":false,"given":"Chun-Fu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan"},{"name":"Program in Molecular Medicine, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-7188","authenticated-orcid":false,"given":"Yi-Jen","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaa-Jyuhn James","family":"Meir","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Chang Gung University, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1960","authenticated-orcid":false,"given":"Chao-Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30010, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Department of Medicine, College of Medicine, Chang Gung University, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.exer.2008.10.016","article-title":"Posterior capsule opacification","volume":"88","author":"Wormstone","year":"2009","journal-title":"Exp. 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