{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:14:52Z","timestamp":1774653292706,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary","award":["\u00daNKP-21-4-II-SE-10"],"award-info":[{"award-number":["\u00daNKP-21-4-II-SE-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A compact handheld skin ultrasound imaging device has been developed that uses co-registered optical and ultrasound imaging to provide diagnostic information about the full skin depth. The aim of the current work is to present the preliminary clinical results of this device. Using additional photographic, dermoscopic and ultrasonic images as reference, the images from the device were assessed in terms of the detectability of the main skin layer boundaries and characteristic image features. Combined optical-ultrasonic recordings of various types of skin lesions (melanoma, basal cell carcinoma, seborrheic keratosis, dermatofibroma, naevus, dermatitis and psoriasis) were taken with the device (N = 53) and compared with images captured with a reference portable skin ultrasound imager. The investigator and two additional independent experts performed the evaluation. The detectability of skin structures was over 90% for the epidermis, the dermis and the lesions. The morphological and echogenicity information observed for the different skin lesions were found consistent with those of the reference ultrasound device and relevant ultrasound images in the literature. The presented device was able to obtain simultaneous in-vivo optical and ultrasound images of various skin lesions. This has the potential for further investigations, including the preoperative planning of skin cancer treatment.<\/jats:p>","DOI":"10.3390\/diagnostics12010204","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preliminary Clinical Experience with a Novel Optical\u2013Ultrasound Imaging Device on Various Skin Lesions"],"prefix":"10.3390","volume":"12","author":[{"given":"Gergely","family":"Cs\u00e1ny","sequence":"first","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"},{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter utca 50\/A, 1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3 Hunor","family":"Gergely","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, M\u00e1ria utca 41, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-1755","authenticated-orcid":false,"given":"Norbert","family":"Kiss","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"},{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, M\u00e1ria utca 41, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Szalai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, M\u00e1ria utca 41, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-1008","authenticated-orcid":false,"given":"Kende","family":"L\u0151rincz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, M\u00e1ria utca 41, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Strobel","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domonkos","family":"Csabai","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Maros\u00e1n-Vilimszky","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"},{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter utca 50\/A, 1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n","family":"F\u00fczesi","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"},{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter utca 50\/A, 1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-5093","authenticated-orcid":false,"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, M\u00e1ria utca 41, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Gy\u00f6ngy","sequence":"additional","affiliation":[{"name":"Dermus Ltd., Sopron \u00fat 64, 1116 Budapest, Hungary"},{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter utca 50\/A, 1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wilhelm, K.P., Elsner, P., Berardesca, E., and Maibach, H.I. 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