{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T14:47:56Z","timestamp":1772635676367,"version":"3.50.1"},"reference-count":107,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009960","name":"Pirkanmaa Hospital District","doi-asserted-by":"publisher","award":["X5211"],"award-info":[{"award-number":["X5211"]}],"id":[{"id":"10.13039\/501100009960","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pirkanmaa Cancer Foundation","award":["2016"],"award-info":[{"award-number":["2016"]}]},{"name":"Charles University Research Fund","award":["Progres Q28\/LF1"],"award-info":[{"award-number":["Progres Q28\/LF1"]}]},{"name":"Charles University Research Fund","award":["Progres Q39"],"award-info":[{"award-number":["Progres Q39"]}]},{"name":"Operational Programme Research, Development and Education project \u201cCenter for Tumor Ecology \u2013 Research of the Cancer Microenvironment Supporting Cancer Growth and Spread\u201d","award":["CZ.02.1.01.\/0.0\/0.0\/16_019\/0000785"],"award-info":[{"award-number":["CZ.02.1.01.\/0.0\/0.0\/16_019\/0000785"]}]},{"name":"Ministry of Health, Czech Republic \u2013 Conceptual development of research organization","award":["Faculty Hospital in Pilsen \u2013 FNPI, 00669806"],"award-info":[{"award-number":["Faculty Hospital in Pilsen \u2013 FNPI, 00669806"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diagnosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.<\/jats:p>","DOI":"10.3390\/diagnostics12020250","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T22:40:20Z","timestamp":1642718420000},"page":"250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-0450","authenticated-orcid":false,"given":"Ivana","family":"Kholov\u00e1","sequence":"first","affiliation":[{"name":"Pathology, Fimlab Laboratories, Arvo Ylp\u00f6n Katu 4, 33520 Tampere, Finland"},{"name":"Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n Katu 34, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Haaga","sequence":"additional","affiliation":[{"name":"Pathology, Fimlab Laboratories, Arvo Ylp\u00f6n Katu 4, 33520 Tampere, Finland"},{"name":"Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n Katu 34, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Ludvik","sequence":"additional","affiliation":[{"name":"Department of Imaging Methods, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 80, 30460 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-4113","authenticated-orcid":false,"given":"David","family":"Kalfert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, University Hospital Motol, Charles University, 15006 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-5689","authenticated-orcid":false,"given":"Marie","family":"Ludvikova","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine in Pilsen, Charles University, 32300 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1210\/jc.2016-2976","article-title":"The History of the Follicular Variant of Papillary Thyroid Carcinoma","volume":"102","author":"Tallini","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","first-page":"623","article-title":"Natural history of thyroid carcinoma","volume":"17","author":"Lindsay","year":"1960","journal-title":"Ariz. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00000478-197706000-00003","article-title":"Follicular variant of thyroid papillary carcinoma: A clinicopathologic study of six cases","volume":"1","author":"Chem","year":"1977","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/106689690000800304","article-title":"Guest Editorial: Two Proposals Regarding the Terminology of Thyroid Tumors","volume":"8","author":"Williams","year":"2000","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/jamaoncol.2016.0386","article-title":"Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors","volume":"2","author":"Nikiforov","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_6","unstructured":"Lloyd, R.V., Osamura, R.Y., Kl\u00f6ppel, G., and Rosai, J. (2017). WHO Classification of Tumours of Endocrine Organs, International Agency for Research on Cancer."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/thy.2016.0628","article-title":"American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features","volume":"27","author":"Haugen","year":"2017","journal-title":"Thyroid"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/thy.2016.0205","article-title":"Changing the Cancer Diagnosis: The Case of Follicular Variant of Papillary Thyroid Cancer-Primum Non Nocere and NIFTP","volume":"26","author":"Hodak","year":"2016","journal-title":"Thyroid"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00268-017-4182-5","article-title":"Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign?","volume":"42","author":"Parente","year":"2018","journal-title":"World J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/his.13401","article-title":"Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma","volume":"72","author":"Kim","year":"2018","journal-title":"Histopathology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/modpathol.2017.9","article-title":"Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: The impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features","volume":"30","author":"Cho","year":"2017","journal-title":"Mod. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/jamaoncol.2018.1446","article-title":"Change in Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm With Papillarylike Nuclear Features","volume":"4","author":"Nikiforov","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e576","DOI":"10.6061\/clinics\/2018\/e576","article-title":"Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP): Achieving Better Agreement By Refining Diagnostic Criteria","volume":"73","author":"Alves","year":"2018","journal-title":"Clinics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5858\/arpa.2019-0689-RA","article-title":"Noninvasive Follicular Tumor with Papillary-like Nuclear Features: A Practice Changer in Thyroid Pathology","volume":"145","author":"LiVolsi","year":"2021","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/modpathol.2017.130","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A review for pathologists","volume":"31","author":"Seethala","year":"2018","journal-title":"Mod. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fakhar, Y., Khooei, A., Aghaee, A., Mohammadzadeh Kosari, H., Wartofsky, L., and Zakavi, S.R. (2021). Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00883-7"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R259","DOI":"10.1530\/ERC-19-0048","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A review for clinicians","volume":"26","author":"Rosario","year":"2019","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref_18","first-page":"1502","article-title":"The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification","volume":"31","author":"Rana","year":"2021","journal-title":"Thyroid"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/pin.12779","article-title":"Interobserver and intraobserver variation in the morphological evaluation of noninvasive follicular thyroid neoplasm with papillary-like nuclear features in Asian practice","volume":"69","author":"Liu","year":"2019","journal-title":"Pathol. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/01.pas.0000135519.34847.f6","article-title":"Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma","volume":"28","author":"Lloyd","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1309\/AJCPKP2QUVN4RCCP","article-title":"Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma","volume":"130","author":"Elsheikh","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3803\/EnM.2020.860","article-title":"Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms","volume":"36","author":"Jung","year":"2021","journal-title":"Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12022-018-9519-6","article-title":"Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology","volume":"29","author":"Bychkov","year":"2018","journal-title":"Endocr. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12022-019-09583-4","article-title":"Systematic Review and Meta-analysis of the Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Cytological Diagnosis and Thyroid Cancer Prevalence","volume":"30","author":"Ruanpeng","year":"2019","journal-title":"Endocr. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","year":"2014","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3803\/EnM.2020.304","article-title":"Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E","volume":"35","author":"Song","year":"2020","journal-title":"Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1089\/thy.2016.0547","article-title":"Molecular Profiling of Papillary Thyroid Carcinoma in Korea with a High Prevalence of BRAF(V600E) Mutation","volume":"27","author":"Lee","year":"2017","journal-title":"Thyroid"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/cncy.21848","article-title":"Can noninvasive follicular thyroid neoplasm with papillary-like nuclear features be distinguished from classic papillary thyroid carcinoma and follicular adenomas by fine-needle aspiration?","volume":"125","author":"Brandler","year":"2017","journal-title":"Cancer Cytopathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12022-018-9515-x","article-title":"Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)","volume":"29","author":"Strickland","year":"2018","journal-title":"Endocr. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cncy.21839","article-title":"Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma","volume":"125","author":"Zhao","year":"2017","journal-title":"Cancer Cytopathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1089\/thy.2016.0583","article-title":"Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Accounts for More Than Half of \u201cCarcinomas\u201d Harboring RAS Mutations","volume":"27","author":"Paulson","year":"2017","journal-title":"Thyroid"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.21037\/gs.2018.12.01","article-title":"The impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the diagnosis of thyroid nodules","volume":"8","author":"Pusztaszeri","year":"2019","journal-title":"Gland Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00428-018-02512-6","article-title":"Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)","volume":"474","author":"Pool","year":"2019","journal-title":"Virchows Arch."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1530\/EC-19-0566","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A problematic entity","volume":"9","author":"Zajkowska","year":"2020","journal-title":"Endocr. Connect."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/dc.23863","article-title":"Does noninvasive follicular thyroid neoplasm with papillary-like nuclear features have distinctive features on sonography?","volume":"46","author":"Brandler","year":"2018","journal-title":"Diagn. Cytopathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1089\/thy.2015.0227","article-title":"Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation","volume":"26","author":"Afkhami","year":"2016","journal-title":"Thyroid"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"838","DOI":"10.5858\/arpa.2017-0118-OA","article-title":"Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features Are Genetically and Biologically Similar to Adenomatous Nodules and Distinct From Papillary Thyroid Carcinomas with Extensive Follicular Growth","volume":"142","author":"Johnson","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12020-019-01887-z","article-title":"Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): A review and update","volume":"64","author":"Geramizadeh","year":"2019","journal-title":"Endocrine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/thy.2016.0671","article-title":"Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma","volume":"28","author":"Kim","year":"2018","journal-title":"Thyroid"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1089\/thy.2018.0198","article-title":"Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma","volume":"28","author":"Song","year":"2018","journal-title":"Thyroid"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E754","DOI":"10.1210\/jc.2013-3734","article-title":"TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas","volume":"99","author":"Melo","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.18632\/genesandcancer.213","article-title":"Are molecular tests necessary to diagnose NIFTP?","volume":"12","author":"Kuchareczko","year":"2021","journal-title":"Genes Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12253-019-00639-8","article-title":"Molecular Profile and Clinicopathologic Features of Follicular Variant Papillary Thyroid Carcinoma","volume":"26","author":"Sohn","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R247","DOI":"10.1530\/ERC-17-0513","article-title":"Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Impact on the reclassification of thyroid nodules","volume":"25","author":"Amendoeira","year":"2018","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1530\/EC-19-0459","article-title":"Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior","volume":"8","author":"Paniza","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/thy.2017.0127","article-title":"Discriminatory miRNAs for the Management of Papillary Thyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features","volume":"28","author":"Jahanbani","year":"2018","journal-title":"Thyroid"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Park, J.L., Kim, S.K., Jeon, S., Jung, C.K., and Kim, Y.S. (2021). MicroRNA Profile for Diagnostic and Prognostic Biomarkers in Thyroid Cancer. Cancers, 13.","DOI":"10.3390\/cancers13040632"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/modpathol.2016.157","article-title":"miRNA expression profiling of \u2018noninvasive follicular thyroid neoplasms with papillary-like nuclear features\u2019 compared with adenomas and infiltrative follicular variants of papillary thyroid carcinomas","volume":"30","author":"Borrelli","year":"2017","journal-title":"Mod. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kalfert, D., Ludvikova, M., Pesta, M., Ludvik, J., Dostalova, L., and Kholova, I. (2020). Multifunctional Roles of miR-34a in Cancer: A Review with the Emphasis on Head and Neck Squamous Cell Carcinoma and Thyroid Cancer with Clinical Implications. Diagnostics, 10.","DOI":"10.3390\/diagnostics10080563"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000442145","article-title":"Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration","volume":"59","author":"Ludvikova","year":"2015","journal-title":"Acta Cytol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000495151","article-title":"Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy","volume":"42","author":"Jalali","year":"2019","journal-title":"Oncol. Res. Treat."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"591.e1","DOI":"10.1016\/j.crad.2017.12.008","article-title":"Histogram analysis of greyscale sonograms to differentiate between the subtypes of follicular variant of papillary thyroid cancer","volume":"73","author":"Kwon","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.14366\/usg.17045","article-title":"Pathologic basis of the sonographic differences between thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features","volume":"37","author":"Yang","year":"2018","journal-title":"Ultrasonography"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1148\/radiol.2018172572","article-title":"Reduction in Thyroid Nodule Biopsies and Improved Accuracy with American College of Radiology Thyroid Imaging Reporting and Data System","volume":"287","author":"Hoang","year":"2018","journal-title":"Radiology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"20201444","DOI":"10.1259\/bjr.20201444","article-title":"Comparison of British Thyroid Association, American College of Radiology TIRADS and Artificial Intelligence TIRADS with histological correlation: Diagnostic performance for predicting thyroid malignancy and unnecessary fine needle aspiration rate","volume":"94","author":"Watkins","year":"2021","journal-title":"Br. J. Radiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiol.2017171240","article-title":"Thyroid Imaging Reporting and Data System (TI-RADS): A User\u2019s Guide","volume":"287","author":"Tessler","year":"2018","journal-title":"Radiology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacr.2017.01.046","article-title":"ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee","volume":"14","author":"Tessler","year":"2017","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3348\/kjr.2016.17.3.370","article-title":"Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations","volume":"17","author":"Shin","year":"2016","journal-title":"Korean J. Radiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/EJE-18-0083","article-title":"Differences between ATA, AACE\/ACE\/AME and ACR TI-RADS ultrasound classifications performance in identifying cytological high-risk thyroid nodules","volume":"178","author":"Maddaloni","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2214\/AJR.17.18822","article-title":"Comparison of Performance Characteristics of American College of Radiology TI-RADS, Korean Society of Thyroid Radiology TIRADS, and American Thyroid Association Guidelines","volume":"210","author":"Middleton","year":"2018","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/jso.24700","article-title":"Preoperative clinicopathological characteristics of patients with solitary encapsulated follicular variants of papillary thyroid carcinomas","volume":"116","author":"Kwon","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/dc.23709","article-title":"Sonographic and cytologic differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thyroid carcinoma: A Review of 179 Cases","volume":"45","author":"Yang","year":"2017","journal-title":"Diagn. Cytopathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jasc.2020.01.002","article-title":"Can cytology and the Thyroid Imaging, Reporting, and Data System (TI-RADS) identify noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) before surgery?","volume":"9","author":"Yang","year":"2020","journal-title":"J. Am. Soc. Cytopathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/cen.13263","article-title":"Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP","volume":"86","author":"Hahn","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lee, H.S., Lee, J.W., Park, J.H., Kim, W.S., Han, H.S., and Lee, S.E. (2019). Comprehensive analysis for diagnosis of preoperative non-invasive follicular thyroid neoplasm with papillary-like nuclear features. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0218046"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/thy.2016.0677","article-title":"Role of Ultrasound in Predicting Tumor Invasiveness in Follicular Variant of Papillary Thyroid Carcinoma","volume":"27","author":"Hahn","year":"2017","journal-title":"Thyroid"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ando.2019.10.004","article-title":"Ultrasound and cytological characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features compared to papillary carcinomas","volume":"81","author":"Boursier","year":"2020","journal-title":"Ann. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/cen.13523","article-title":"Is Doppler ultrasonography of value for the differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma?","volume":"88","author":"Rosario","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/cen.13473","article-title":"Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results","volume":"88","author":"You","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1089\/thy.2021.0119","article-title":"Do Ultrasound Patterns and Clinical Parameters Inform the Probability of Thyroid Cancer Predicted by Molecular Testing in Nodules with Indeterminate Cytology?","volume":"31","author":"Figge","year":"2021","journal-title":"Thyroid"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11547-019-01129-2","article-title":"Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: A systematic review and meta-analysis using histological standard of reference","volume":"125","author":"Trimboli","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.14366\/usg.18037","article-title":"Ultrasound elastography of the thyroid: Principles and current status","volume":"38","author":"Zhao","year":"2019","journal-title":"Ultrasonography"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12020-014-0438-0","article-title":"Diagnostic performance of elastography in cytologically indeterminate thyroid nodules","volume":"49","author":"Garino","year":"2015","journal-title":"Endocrine"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Stoian, D., Borcan, F., Petre, I., Mozos, I., Varcus, F., Ivan, V., Cioca, A., Apostol, A., and Dehelean, C.A. (2019). Strain Elastography as a Valuable Diagnosis Tool in Intermediate Cytology (Bethesda III) Thyroid Nodules. Diagnostics, 9.","DOI":"10.3390\/diagnostics9030119"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Borlea, A., Stoian, D., Cotoi, L., Sporea, I., Lazar, F., and Mozos, I. (2020). Thyroid Multimodal Ultrasound Evaluation\u2014Impact on Presurgical Diagnosis of Intermediate Cytology Cases. Appl. Sci., 10.","DOI":"10.3390\/app10103439"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cyt.12537","article-title":"Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A comparative study with similar patterned papillary thyroid carcinoma variants","volume":"29","author":"Mahajan","year":"2018","journal-title":"Cytopathology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.humpath.2016.03.014","article-title":"Cytological features of \u201cnoninvasive follicular thyroid neoplasm with papillary-like nuclear features\u201d and their correlation with tumor histology","volume":"54","author":"Maletta","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/cncy.21910","article-title":"Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management","volume":"125","author":"Chandler","year":"2017","journal-title":"Cancer Cytopathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000488579","article-title":"Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?","volume":"62","year":"2018","journal-title":"Acta Cytol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1507\/endocrj.EJ17-0214","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A single-institutional experience in Japan","volume":"64","author":"Hirokawa","year":"2017","journal-title":"Endocr. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1507\/endocrj.EJ20-0198","article-title":"Prevalence and diagnostic significance of noninvasive follicular thyroid neoplasm with papillary-like nuclear features among tumors previously diagnosed as follicular adenoma: A single-institutional study in Japan","volume":"67","author":"Hirokawa","year":"2020","journal-title":"Endocr. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1309\/AJCPEIE12POICULI","article-title":"Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma","volume":"144","author":"Howitt","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/cyt.12459","article-title":"The impact of the non-invasive follicular thyroid neoplasm with papillary-like nuclear feature terminology in the routine diagnosis of thyroid tumours","volume":"28","author":"Jaconi","year":"2017","journal-title":"Cytopathology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1507\/endocrj.EJ18-0525","article-title":"Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features","volume":"66","author":"Koshikawa","year":"2019","journal-title":"Endocr. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jasc.2018.07.004","article-title":"Distinguishing non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) from classic and invasive follicular-variant papillary thyroid carcinomas based on cytologic features","volume":"8","author":"Legesse","year":"2019","journal-title":"J. Am. Soc. Cytopathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/jpi.jpi_25_19","article-title":"Differentiating Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features from Classic Papillary Thyroid Carcinoma: Analysis of Cytomorphologic Descriptions Using a Novel Machine-Learning Approach","volume":"10","author":"Maleki","year":"2019","journal-title":"J. Pathol. Inform."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/dc.24259","article-title":"The presence of multinucleated giant cells: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features vs the follicular variant of papillary thyroid carcinoma","volume":"47","author":"Selvaggi","year":"2019","journal-title":"Diagn. Cytopathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1089\/thy.2014.0612","article-title":"The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories","volume":"25","author":"Strickland","year":"2015","journal-title":"Thyroid"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1089\/thy.2016.0280","article-title":"Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis","volume":"26","author":"Strickland","year":"2016","journal-title":"Thyroid"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/dc.24309","article-title":"Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine-needle aspiration","volume":"47","author":"Yan","year":"2019","journal-title":"Diagn. Cytopathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jasc.2018.07.007","article-title":"Cytological features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)","volume":"8","author":"Zhang","year":"2019","journal-title":"J. Am. Soc. Cytopathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/cncy.21777","article-title":"Young investigator challenge: The morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: Some insights into their identification","volume":"124","author":"Bizzarro","year":"2016","journal-title":"Cancer Cytopathol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Haaga, E., Kalfert, D., Ludvikova, M., and Kholova, I. (2021). Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Is Not a Cytological Diagnosis, but It Influences Cytological Diagnosis Outcomes: A Systematic Review and Meta-Analysis. Acta Cytol., 1\u201321.","DOI":"10.1159\/000519757"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ali, S.Z., and Cibas, E.S. (2010). The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria and Explanatory Notes, Springer. [1st ed.].","DOI":"10.1007\/978-0-387-87666-5"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ali, S.Z., and Cibas, E.S. (2018). The Bethesda System for Reporting Thyroid Cytopathology, Springer. [2nd ed.].","DOI":"10.1007\/978-3-319-60570-8"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1089\/thy.2018.0394","article-title":"Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis","volume":"29","author":"Bongiovanni","year":"2019","journal-title":"Thyroid"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cncy.21631","article-title":"Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology","volume":"124","author":"Faquin","year":"2016","journal-title":"Cancer Cytopathol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Shrestha, R.T., Ruanpeng, D., and Hennessey, J.V. (2019). Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing. Med. Sci., 7.","DOI":"10.3390\/medsci7020015"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/cncy.21744","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A changing paradigm in thyroid surgical pathology and implications for thyroid cytopathology","volume":"124","author":"Baloch","year":"2016","journal-title":"Cancer Cytopathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/ajcp\/aqx136","article-title":"Impact of the Reclassification of \u201cNoninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma\u201d to \u201cNoninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features\u201d on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution\u2019s Experience","volume":"149","author":"Lau","year":"2017","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000469654","article-title":"Impact of the Reclassification of the Non-Invasive Follicular Variant of Papillary Carcinoma as Benign on the Malignancy Risk of the Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis Study","volume":"61","author":"Layfield","year":"2017","journal-title":"Acta Cytol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/EJE-19-0223","article-title":"Impact of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) on risk of malignancy in patients undergoing lobectomy\/thyroidectomy for suspected malignancy or malignant fine-needle aspiration cytology findings: A systematic review and meta-analysis","volume":"181","author":"Bongiovanni","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.surg.2018.04.089","article-title":"NIFT-P: Are they indolent tumors? Results of a multi-institutional study","volume":"165","author":"Chereau","year":"2019","journal-title":"Surgery"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jss.2018.04.013","article-title":"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features reclassification and its impact on thyroid malignancy rate and treatment","volume":"230","author":"Mao","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.surg.2017.04.041","article-title":"New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution","volume":"163","author":"Kiernan","year":"2018","journal-title":"Surgery"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.21037\/gs.2017.08.02","article-title":"How to handle borderline\/precursor thyroid tumors in management of patients with thyroid nodules","volume":"7","author":"Kakudo","year":"2018","journal-title":"Gland Surg."},{"key":"ref_107","first-page":"3","article-title":"Unsettled issues in Non-invasive encapsulated\/well circumscribed follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and precursor thyroid tumors","volume":"6","author":"Kakudo","year":"2017","journal-title":"J. Basic Clin. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/2\/250\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:04:21Z","timestamp":1760133861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/2\/250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":107,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["diagnostics12020250"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12020250","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]}}}