{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T23:03:18Z","timestamp":1771369398576,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Atypical polypoid adenomyoma (APA) is a rare tumor developed from a mix of cells of epithelial and mesenchymal origin. We present the case of an 84-year-old patient with atypical polypoid adenomyoma on the vaginal vault, after total hysterectomy with total adnexectomy for endometrial hyperplasia with atypia four years ago. Not following regular indicated gynecological appointments, the symptoms presented were vaginal bleeding and anemia. The importance of the case consists both in the unique way in which the adenomyoma appears on the vaginal vault and in the subsequent evolution of this pathology. After complete resection, it recurs in five months with a malignant transformation into carcinosarcoma. This fact shows that adenomas can turn not only into carcinomas but also the mesenchymal component can progress to sarcoma, a fact of exceptional rarity. Follow-up and accurate diagnosis are essential for proper management, which is a challenge anyway due to the lack of case studies.<\/jats:p>","DOI":"10.3390\/diagnostics12020368","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T09:59:21Z","timestamp":1643709561000},"page":"368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical Polypoid Adenomyoma of the Vagina: Follow Up and Subsequent Evolution: A Case Report and Update"],"prefix":"10.3390","volume":"12","author":[{"given":"Melinda Ildiko","family":"Mitranovici","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioan Emilian","family":"Oal\u0103","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabella","family":"Petre","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Victor Babe\u0219 University of Medicine and Pharmacy, 2 Eftimie Murgu Sq, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius Lucian","family":"Craina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Victor Babe\u0219 University of Medicine and Pharmacy, 2 Eftimie Murgu Sq, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviana Narcisa","family":"Floru\u021b","sequence":"additional","affiliation":[{"name":"Department of Pathology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-2916","authenticated-orcid":false,"given":"Diana Maria","family":"Chiorean","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-2433","authenticated-orcid":false,"given":"Iuliu Gabriel","family":"Cocuz","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pathology, County Clinical Hospital of T\u00e2rgu Mure\u0219, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabin Gligore","family":"Turdean","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu Simion","family":"Cotoi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 38 Gheorghe Marinescu Street, 540142 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pathology, County Clinical Hospital of T\u00e2rgu Mure\u0219, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian","family":"Pu\u0219ca\u0219iu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology County Emergency Hospital, University of Medicine and Pharmacty Targu Mures, 38 Gh. Marinescu Str., 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/ijgc-2020-001886","article-title":"Atypical polypoid adenomyoma","volume":"31","author":"Grindstaff","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2017.05.017","article-title":"Management of atypical polypoid adenomyomas. A case series","volume":"215","author":"Grimbizis","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. 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