{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:51:07Z","timestamp":1760151067396,"version":"build-2065373602"},"reference-count":6,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly-progressive dementing illness, the challenge of diagnosis during life. We presented a 78-year-old woman reported stupor, right facial palsy, and fluctuations in consciousness. 99mTc-ECD brain SPECT\/CT with eZIS analysis revealed significant decreased regional cerebral blood flow mainly in specific regions of Alzheimer\u2019s disease as the published article reported with involving frontal region. Brain DWI MRI increased signal intensities corresponding to similar location of 99mTc-ECD brain SPECT\/CT. In this case, we reported the pattern of decreased rCBF may correlate to rapidly progressive dementia and associated neurodegenerative symptoms of the highly suspected sCJD patient.<\/jats:p>","DOI":"10.3390\/diagnostics12020437","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T01:03:40Z","timestamp":1644368620000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Specifically Regional Cerebral Hypoperfusion in a Case of Highly Suspected Sporadic Creutzfeldt-Jakob Disease on 99mTc-ECD SPECT\/CT with Easy Z-Score Imaging System Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-5176","authenticated-orcid":false,"given":"Shun-Chieh","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Hueng-Yuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Yen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"},{"name":"Graduate Institute of Science and Technology Law, National Kaohsiung University of Science and Technology, Kaohsiung 80778, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-0498","authenticated-orcid":false,"given":"Ming-Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-5824","authenticated-orcid":false,"given":"Hung-Pin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/ccr3.3131","article-title":"Sporadic Creutzfeldt-Jakob disease: A case report and review of literature","volume":"8","author":"Ojha","year":"2020","journal-title":"Clin. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/jnnp.2006.094821","article-title":"Neuroimaging findings in human prion disease","volume":"78","author":"Macfarlane","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/brain\/awp191","article-title":"Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease","volume":"132","author":"Zerr","year":"2009","journal-title":"Brain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/RLU.0b013e3182175497","article-title":"Two Sequential Tc-99m ECD SPECT Studies in a Case of Sporadic Creutzfeldt\u2013Jakob Disease Confirmed at Autopsy","volume":"36","author":"Paghera","year":"2011","journal-title":"Clin. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1148\/rg.2017160075","article-title":"Imaging of Creutzfeldt-Jakob Disease: Imaging Patterns and Their Differential Diagnosis","volume":"37","author":"Fragoso","year":"2017","journal-title":"Radiographics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jns.2007.03.027","article-title":"Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) as an adjunct to early-diagnosis of neurodegenerative diseases","volume":"260","author":"Waragai","year":"2007","journal-title":"J. Neurol. Sci."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/2\/437\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:16:22Z","timestamp":1760134582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/2\/437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["diagnostics12020437"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12020437","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2022,2,8]]}}}