{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:14:04Z","timestamp":1791598444534,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NE 2136\/3\u20101"],"award-info":[{"award-number":["NE 2136\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01EC1009A"],"award-info":[{"award-number":["FKZ 01EC1009A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Faculty of the University Dusseldorf","award":["2020-18"],"award-info":[{"award-number":["2020-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Currently, clinical indications for the application of gadolinium-based contrast agents (GBCA) in magnetic resonance imaging (MRI) are increasingly being questioned. Consequently, this study aimed to evaluate the additional diagnostic value of contrast enhancement in MRI of the hand in patients with rheumatoid arthritis (RA). Thirty-one patients with RA (mean age, 50 \u00b1 14 years (range, 18\u201372 years)) underwent morphologic MRI scans on a clinical 3 T scanner. MRI studies were analyzed based on (1) the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) and (2) the GBCA-free RAMRIS version, termed RAMRIS Sine-Gadolinium-For-Experts (RAMRIS-SAFE), in which synovitis and tenosynovitis were assessed using the short-tau inversion-recovery sequence instead of the post-contrast T1-weighted sequence. The synovitis subscores in terms of Spearman\u2019s \u03c1, as based on RAMRIS and RAMRIS-SAFE, were almost perfect (\u03c1 = 0.937; p &lt; 0.001), while the tenosynovitis subscores were less strongly correlated (\u03c1 = 0.380 p = 0.035). Correlation between the total RAMRIS and RAMRIS-SAFE was also almost perfect (\u03c1 = 0.976; p &lt; 0.001). Inter-rater reliability in terms of Cohen\u2019s \u03ba was high (0.963 \u2264 \u03ba \u2264 0.925). In conclusion, RAMRIS-SAFE as the GBCA-free version of the well-established RAMRIS is a patient-friendly and resource-efficient alternative for assessing disease-related joint changes in RA. As patients with RA are subject to repetitive GBCA applications, non-contrast imaging protocols should be considered.<\/jats:p>","DOI":"10.3390\/diagnostics12020465","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:08:43Z","timestamp":1644786523000},"page":"465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["To Contrast or Not to Contrast? On the Role of Contrast Enhancement in Hand MRI Studies of Patients with Rheumatoid Arthritis"],"prefix":"10.3390","volume":"12","author":[{"given":"Miriam","family":"Frenken","sequence":"first","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesa","family":"R\u00fcbsam","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit of Rheumatology, Heinrich Heine University D\u00fcsseldorf, UKD, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mewes","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-1283","authenticated-orcid":false,"given":"Karl Ludger","family":"Radke","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Marchioninistr. 15, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-863X","authenticated-orcid":false,"given":"Lena M.","family":"Wilms","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-9962","authenticated-orcid":false,"given":"Sven","family":"Nebelung","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-4431","authenticated-orcid":false,"given":"Daniel B.","family":"Abrar","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital of D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 Dusseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-6207","authenticated-orcid":false,"given":"Philipp","family":"Sewerin","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit of Rheumatology, Heinrich Heine University D\u00fcsseldorf, UKD, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"},{"name":"Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, 44649 Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","first-page":"S237","article-title":"Improved health-related quality of life with effective disease-modifying antirheumatic drugs: Evidence from randomized controlled trials","volume":"13","author":"Strand","year":"2007","journal-title":"Am. 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