{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:35:11Z","timestamp":1778614511766,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The COVID-19 disease, caused by infection with SARS-CoV-2, rapidly transformed into a pandemic following its emergence, and it continues to affect the population at a global level. This disease is associated with high mortality rates and mainly affects the pulmonary spectrum, with signs of interstitial pneumonia or other pathological modifications. Signs indicative of SARS-CoV-2 infection can be observed using pulmonary radiography or computed tomography scans and are closely linked to acute respiratory distress; however, there is accumulating evidence that the virus affects the central nervous system. Several symptoms, such as headaches, cough, fatigue, myalgia, ageusia, and anosmia, have also been reported along with neurological syndromes such as stroke, encephalopathy, Guillain\u2013Barre syndrome, convulsions, and coma; the most frequent associated complication is ischemic stroke. Diagnosis of infection with SARS-CoV-2 virus is based on a positive RT-PCR test. Imaging investigations, such as thoracic computed tomography scans, are not used to diagnose COVID-19, monitor for pulmonary disease, or follow dynamic disease evolution, but they may be used in the case of a negative RT-PCR test. This paper presents the research performed on a group of 150 cases of patients affected by neurological disorders and that were subsequently confirmed to be infected with SARS-CoV-2, which was carried out over a period of 10 months within the Neurology Department and Laboratory of Magnetic Resonance Imaging of \u201cSf. Andrei\u201d Emergency Hospital in Constanta. The collected data are observational and provide perspectives on the neurological pathology associated with the SARS-CoV-2 virus, and on the frequently associated risk factors, associated comorbidities, and the ages of patients who were affected by the virus, as well as the clinical and paraclinical manifestations of the patients admitted to the hospital\u2019s neurology department.<\/jats:p>","DOI":"10.3390\/diagnostics12020473","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:08:43Z","timestamp":1644786523000},"page":"473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of SARS-CoV-2 Infection in Patients with Neurological Pathology"],"prefix":"10.3390","volume":"12","author":[{"given":"Any Docu","family":"Axelerad","sequence":"first","affiliation":[{"name":"Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia Florenta","family":"Muja","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Zorina","family":"Stroe","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia Alexandra","family":"Zlotea","sequence":"additional","affiliation":[{"name":"Radiology-Medical Imaging, Sf. Apostol Andrei Emergency County Clinical Hospital Constanta, 900591 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Adella","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Titu Maiorescu University, 040441 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu","family":"Docu Axelerad","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, \u2018Vasile Goldis\u2019 University, 317046 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragos Catalin","family":"Jianu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina Elena","family":"Frecus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Maria","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"ref_1","unstructured":"(2021, December 27). World Health Organization (WHO). Available online: https:\/\/www.who.int\/."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Guadarrama-Ortiz, P., Chore\u00f1o-Parra, J.A., S\u00e1nchez-Mart\u00ednez, C.M., Pacheco-S\u00e1nchez, F.J., Rodr\u00edguez-Nava, A.I., and Garc\u00eda-Quintero, G. (2020). Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.01039"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10072-020-04486-3","article-title":"The neurological manifestations of COVID-19: A review article","volume":"41","author":"Niazkar","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101091","DOI":"10.1016\/j.inat.2021.101091","article-title":"Cerebral venous sinus thrombosis in patients with COVID-19 infection","volume":"24","author":"Abouhashem","year":"2021","journal-title":"Interdiscip. Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2214\/AJR.20.23034","article-title":"Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients","volume":"215","author":"Salehi","year":"2020","journal-title":"Am. J. Roentgenol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jamaneurol.2020.2065","article-title":"Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review","volume":"77","author":"Zubair","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1007\/s10072-020-04801-y","article-title":"Neurological manifestations of COVID-19: A systematic review and meta-analysis of proportions","volume":"41","author":"Favas","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s00415-020-09990-2","article-title":"Neurological involvement of coronavirus disease 2019: A systematic review","volume":"267","author":"Ghannam","year":"2020","journal-title":"J. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"653694","DOI":"10.3389\/fnagi.2021.653694","article-title":"Age-Associated Neurological Complications of COVID-19: A Systematic Review and Meta-Analysis","volume":"13","author":"Sullivan","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.31793\/1680-1466.2020.25-2.158","article-title":"The role of the circadian molecular clock in the pathogenesis of the metabolic syndrome","volume":"25","author":"Kaidashev","year":"2020","journal-title":"Endokrynologia"},{"key":"ref_11","first-page":"553","article-title":"Clinical and Psychopathological Characteris-tics of the Autoagressive Behavior in Patients with the First Psychotic Episode with Considering Circadian Rhythms","volume":"70","author":"Boiko","year":"2017","journal-title":"Wiad. Lek."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e13161","DOI":"10.1111\/apha.13161","article-title":"Emerging relevance of circadian rhythms in headaches and neuropathic pain","volume":"225","author":"Burish","year":"2019","journal-title":"Acta Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100147","DOI":"10.1016\/j.bbih.2020.100147","article-title":"Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: Lessons learned and recommendations","volume":"9","author":"Ojeahere","year":"2020","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2147\/PRBM.S264286","article-title":"The Mental Health Impact of the COVID-19 Pandemic: Implications for Sub-Saharan Africa","volume":"13","author":"Semo","year":"2020","journal-title":"Psychol. Res. Behav. Manag."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e100270","DOI":"10.1136\/gpsych-2020-100270","article-title":"COVID-19 mental health care toolkit: An international collaborative effort by Early Career Psychiatrists section","volume":"33","author":"Adiukwu","year":"2020","journal-title":"Gen. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S2215-0366(21)00025-0","article-title":"COVID-19 mental health impact and responses in low-income and middle-income countries: Reimagining global mental health","volume":"8","author":"Kola","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4269\/ajtmh.21-1058","article-title":"Food Security, Conflict, and COVID-19: Perspective from Afghanistan","volume":"106","author":"Islam","year":"2022","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100841","DOI":"10.1016\/j.cegh.2021.100841","article-title":"Impact of poor disease surveillance system on COVID-19 response in africa: Time to rethink and rebuilt","volume":"12","author":"Aborode","year":"2021","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_19","first-page":"1","article-title":"Colossal challenges to healthcare workers combating the second wave of coronavirus disease 2019 (COVID-19) in India","volume":"2","author":"Ghosh","year":"2021","journal-title":"Infect. Control Hosp. 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