{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:23:47Z","timestamp":1792513427624,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut M\u00e9rieux (France)","award":["No number"],"award-info":[{"award-number":["No number"]}]},{"DOI":"10.13039\/501100006137","name":"Institut de Recherche pour le D\u00e9veloppement","doi-asserted-by":"publisher","award":["No number"],"award-info":[{"award-number":["No number"]}],"id":[{"id":"10.13039\/501100006137","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SCAC\u2013 Cultural and Cooperation Department - French Embassy in Ghana","award":["No number"],"award-info":[{"award-number":["No number"]}]},{"name":"The Danish International Development Agency (DANIDA)","award":["No number"],"award-info":[{"award-number":["No number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value &lt; 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score &lt; 3 (p &lt; 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p &lt; 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.<\/jats:p>","DOI":"10.3390\/diagnostics12020524","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:14:46Z","timestamp":1645431286000},"page":"524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria"],"prefix":"10.3390","volume":"12","author":[{"given":"Bernard","family":"Tornyigah","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, 75006 Paris, France"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-6595","authenticated-orcid":false,"given":"Samuel Odarkwei","family":"Blankson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, 75006 Paris, France"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafiou","family":"Adamou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin (IRCB), Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizath","family":"Moussiliou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin (IRCB), Calavi, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Rietmeyer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-9497","authenticated-orcid":false,"given":"Patrick","family":"Tettey","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-2133","authenticated-orcid":false,"given":"Liliane","family":"Dikroh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Addo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-6540","authenticated-orcid":false,"given":"Helena","family":"Lamptey","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroufou J.","family":"Alao","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie, H\u00f4pital M\u00e8re-Enfant la Lagune (CHUMEL), Cotonou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Amoussou","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalo-Universitaire, Surul\u00e9r\u00e9 (CHU-Surul\u00e9r\u00e9), Cotonou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Padounou","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de l\u2019Oueme\/Plateau, Porto-Novo, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roussilhon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de G\u00e9n\u00e9tique Fonctionnelle des Maladies Infectieuses, D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, Institut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Pons","sequence":"additional","affiliation":[{"name":"Laboratoire Commun de Recherche Hospices Civils de Lyon-BioM\u00e9rieux, Centre Hospitalier Lyon-Sud, B\u00e2timent 3F, 165 chemin du Grand Revoyet, 69310 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicta Ayiedu","family":"Mensah","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, 75006 Paris, France"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-231X","authenticated-orcid":false,"given":"Rachida","family":"Tahar","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, MERIT, IRD, 75006 Paris, France"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, February 04). World Malaria Report 2021. Licence 2021, CC BY-NC-SA 3.0 IGO. 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