{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:55:12Z","timestamp":1780451712438,"version":"3.54.1"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: The effects of aging such as osteophyte formation, acral shape changes, cortical tunneling, and bone porosity as well as enthesophytes can be studied in the X-rays of hands. However, during the interpretation of radiographs of the hands, misinterpretation and false-positive findings for psoriatic arthritis often occur because periosteal proliferations of the phalanges are overinterpreted and too little is known about enthesophytes of the phalanges in this area. Method: It included a total of 1153 patients (577 men, 576 women) who presented themselves to the emergency department and received a radiography of their right hand to exclude fractures. The Osseographic Scoring System was used in a modified form to record osteophytes and enthesophytes. A linear regression model for periosteal lesions was computed with age, sex, osteophytes, and global diagnosis as covariables. The inter-reader agreement was assessed using ICC (two-way mixed model) on the sum scores of osteophytes and periosteal lesions. Results: Overall, men exhibited more periosteal lesions, demonstrated by a higher mean sum score of 4.14 vs. 3.21 in women (p = 0.008). In both sexes, the second and third proximal phalanx were most frequently affected by periosteal lesions, but the frequencies were significantly higher in men. The female sex was negatively associated with an extent of periosteal lesions with a standardized beta of \u22120.082 (p = 0.003), while age and osteophytes were positively associated with betas of 0.347 (p &lt; 0.001) and 0.156 (p &lt; 0.001), respectively. The distribution of osteophytes per location did not differ between men and women (p &gt; 0.05). The inter-reader agreement was excellent for periosteal lesions with ICC of 0.982 (95%CI 0.973\u20130.989, p &lt; 0.001). Conclusions: Special care should be taken not to confuse normal periosteal changes in aging with periosteal apposition in psoriatic arthritis.<\/jats:p>","DOI":"10.3390\/diagnostics12030618","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"618","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Osteo-Proliferative Lesions of the Phalanges on Radiography: Associations with Sex, Age, and Osteoarthritis"],"prefix":"10.3390","volume":"12","author":[{"given":"Sandra","family":"Hermann","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Eshed","sequence":"additional","affiliation":[{"name":"Sheba Medical Center, Department of Radiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"S\u00e1enz","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda, Facultad de Medicina, Universidad de Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Doepner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-2420","authenticated-orcid":false,"given":"Katharina","family":"Ziegeler","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-3814","authenticated-orcid":false,"given":"Kay Geert A.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1148\/radiographics.10.5.2217979","article-title":"Introduction to the history of musculoskeletal radiology","volume":"10","author":"Murphy","year":"1990","journal-title":"Radiographics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/157340561702210316151524","article-title":"Imaging in Musculoskeletal Oncology","volume":"17","author":"Spinnato","year":"2021","journal-title":"Curr. Med. Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic Arthritis","volume":"376","author":"Ritchlin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00393-019-00735-9","article-title":"Imaging of psoriatic arthritis and aspects of radiographic progression","volume":"79","author":"Baraliakos","year":"2020","journal-title":"Z. Rheumatol."},{"key":"ref_5","first-page":"24","article-title":"Imaging in peripheral and axial psoriatic arthritis: Contributions to diagnosis, follow-up, prognosis and knowledge of pathogenesis","volume":"36","author":"Felbo","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: Development of new criteria from a large international study","volume":"54","author":"Taylor","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1136\/ard.2007.070243","article-title":"MRI of enthesitis of the appendicular skeleton in spondyloarthritis","volume":"66","author":"Eshed","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/annrheumdis-2014-206347","article-title":"Analysis of periarticular bone changes in patients with cutaneous psoriasis without associated psoriatic arthritis","volume":"75","author":"Simon","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s11547-019-01001-3","article-title":"Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis","volume":"124","author":"Salaffi","year":"2019","journal-title":"Radiol. Med."},{"key":"ref_10","unstructured":"Pavlovsky, O., and Kobyliansky, E. (1999). Population Biology of Human Aging, Angelo Pontecorboli Press."},{"key":"ref_11","first-page":"103","article-title":"Osseographic Score as a Biomarker of Biological Aging","volume":"Volume 5","author":"Kalichman","year":"2008","journal-title":"Biennal Book of EAA \u2018Ageing Related Problems in Past and Present Populations\u2019"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/gerona\/59.3.B218","article-title":"Genetic contribution to biological aging: The Framingham Study","volume":"59","author":"Karasik","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.joca.2007.03.007","article-title":"Hand bone midshaft enthesophytes: The influence of age, sex, and heritability","volume":"15","author":"Kalichman","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00421-006-0351-1","article-title":"Hand-grip strength of young men, women and highly trained female athletes","volume":"99","author":"Leyk","year":"2007","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_16","unstructured":"Valenzuela, M., and Varacallo, M. (2020). Anatomy, Shoulder and Upper Limb, Hand Lumbrical Muscles, StatPearls Publishing LLC."},{"key":"ref_17","first-page":"587","article-title":"Bony palmar ridges of the phalanges of the human fingers","volume":"36","author":"Meng","year":"2014","journal-title":"Surg. Radiol. Anat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1600-0838.2009.00906.x","article-title":"Entheses: Tendon and ligament attachment sites","volume":"19","author":"Benjamin","year":"2009","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0038-1639467","article-title":"Imaging to Differentiate the Various Forms of Seronegative Arthritis","volume":"22","author":"Eshed","year":"2018","journal-title":"Semin. Musculoskelet. Radiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/3\/618\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:29Z","timestamp":1760135429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/3\/618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["diagnostics12030618"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12030618","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]}}}