{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:20:16Z","timestamp":1791613216053,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health &amp; Welfare and Ministry of Science and ICT, Republic of Korea","award":["HU20C0315"],"award-info":[{"award-number":["HU20C0315"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Amyloid positron emission tomography (PET) scan is clinically essential for the non-invasive assessment of the presence and spatial distribution of amyloid-beta deposition in subjects with cognitive impairment suspected to have been a result of Alzheimer\u2019s disease. Quantitative assessment can enhance the interpretation reliability of PET scan; however, its clinical application has been limited due to the complexity of preprocessing. This study introduces a novel deep-learning-based approach for SUVR quantification that simplifies the preprocessing step and significantly reduces the analysis time. Using two heterogeneous amyloid ligands, our proposed method successfully distinguished standardized uptake value ratio (SUVR) between amyloidosis-positive and negative groups. The proposed method\u2019s intra-class correlation coefficients were 0.97 and 0.99 against PETSurfer and PMOD, respectively. The difference of global SUVRs between the proposed method and PETSurfer or PMOD were 0.04 and \u22120.02, which are clinically acceptable. The AUC-ROC exceeded 0.95 for three tools in the amyloid positive assessment. Moreover, the proposed method had the fastest processing time and had a low registration failure rate (1%). In conclusion, our proposed method calculates SUVR that is consistent with PETSurfer and PMOD, and has advantages of fast processing time and low registration failure rate. Therefore, PET quantification provided by our proposed method can be used in clinical practice.<\/jats:p>","DOI":"10.3390\/diagnostics12030623","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Development of Amyloid PET Analysis Pipeline Using Deep Learning-Based Brain MRI Segmentation\u2014A Comparative Validation Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-2729","authenticated-orcid":false,"given":"Jiyeon","family":"Lee","sequence":"first","affiliation":[{"name":"Research Institute, Neurophet Inc., Seoul 06234, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-1373","authenticated-orcid":false,"given":"Seunggyun","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-0069","authenticated-orcid":false,"given":"Regina E. Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute, Neurophet Inc., Seoul 06234, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-0221","authenticated-orcid":false,"given":"Minho","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute, Neurophet Inc., Seoul 06234, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-0259","authenticated-orcid":false,"given":"Donghyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute, Neurophet Inc., Seoul 06234, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-3409","authenticated-orcid":false,"given":"Hyun Kook","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/014662169602000307","article-title":"Longitudinal Models of Reliability and Validity: A Latent Curve Approach","volume":"20","author":"Tisak","year":"1996","journal-title":"Appl. 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