{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:19:23Z","timestamp":1787235563842,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V111C-162"],"award-info":[{"award-number":["V111C-162"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology Taiwan","award":["MOST-110-2622-8-075-001"],"award-info":[{"award-number":["MOST-110-2622-8-075-001"]}]},{"name":"Veterans General Hospitals and University System of Taiwan Joint Research Program","award":["VGHUST111C-140"],"award-info":[{"award-number":["VGHUST111C-140"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The mechanism of tinnitus accompanied by a normal audiogram remains elusive. This study aimed to investigate evidence of primary neural degeneration, also known as cochlear synaptopathy, in tinnitus patients with normal hearing thresholds. We analyzed the differences in electrocochleography (ECochG) measurements between normal-hearing subjects with and without tinnitus. Forty-five subjects were enrolled in this study: 21 were in the tinnitus group, defined by chronic tinnitus of over two months\u2019 duration with normal audiometric thresholds, and 24 were in the control group, defined by a lack of tinnitus complaints. Electrocochleograms were evoked by 1, 4, 6, and 8 kHz alternating-polarity tone bursts at sound pressure levels (SPLs) of 90\u2013110 dB. The tinnitus group had smaller action potential (AP) amplitudes than the control group for 1, 4, 6, and 8 kHz tone bursts and showed significant amplitude reduction at 1 kHz 110 dB SPL (p &lt; 0.01), 1 kHz 90 dB SPL (p &lt; 0.05), and 4 kHz 110 dB SPL (p &lt; 0.05). There were no significant differences in the summating potential\/action potential (SP\/AP) amplitude ratios across the four tested frequencies. A trend of reduced AP amplitudes was found in the tinnitus group, supporting the hypothesis that tinnitus might be associated with primary neural degeneration.<\/jats:p>","DOI":"10.3390\/diagnostics12040802","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:31:21Z","timestamp":1648222281000},"page":"802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Are Electrocochleographic Changes an Early Sign of Cochlear Synaptopathy? A Prospective Study in Tinnitus Patients with Normal Hearing"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-8192","authenticated-orcid":false,"given":"Kuan-Chung","family":"Ting","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Department of Otolaryngology, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"},{"name":"Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-0100","authenticated-orcid":false,"given":"Chii-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-5854","authenticated-orcid":false,"given":"Yen-Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan"},{"name":"Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1044\/1092-4388(2005\/084)","article-title":"General Review of Tinnitus: Prevalence, mechanisms, effects, and management","volume":"48","author":"Henry","year":"2005","journal-title":"J. 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