{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:03:05Z","timestamp":1790704985398,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction: A variety of imaging techniques exists for the diagnosis of pancreatic disorders. None of the broadly applied diagnostic methods utilizes elasticity as an indicator of tissue damage. A well-known fact is that both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDA) are associated with the development of prominent fibrosis (increased tissue stiffness). Purpose: To prospectively assess the accuracy of point shear wave elastography (pSWE) in differentiating between benign and malignant pancreatic diseases, establish a cut-off value for the diagnosis of PDA, and evaluate the influence of certain variables on the obtained results. Materials and methods: The present study included 78 patients who were admitted at the Department of Gastroenterology at the university hospital \u201cKaspela\u201d between December 2017 and August 2021 for diagnosis and\/or treatment of pancreatic disorders. Based on the clinical criteria, diagnostic imaging, and histological findings, patients were divided into the CP and PDA group. The ultrasound based pSWE technique was applied and shear wave velocity (SWV) was measured. The depth of region of interest (ROI) and successful measurement rate were also recorded. Results: The mean \u00b1 SD SWV values established through pSWE were 1.75 \u00b1 0.34 m\/s and 2.93 \u00b1 0.91 m\/s for the CP and PDA, respectively. With a cut-off value of 2.09 m\/s, we calculated the sensitivity (Se), specificity (Sp), and accuracy for differentiating between CP and PDA of 89.47%, 91.20%, and 88.60%, respectively. Of the examined variables, BMI and depth of ROI in the CP group and sex in the PDA group showed a statistically significant influence on the obtained results. Conclusions: pSWE may be utilized as a differential diagnostic modality in patients with suspected CP or PDA.<\/jats:p>","DOI":"10.3390\/diagnostics12040841","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:40:14Z","timestamp":1648590014000},"page":"841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Ultrasound-Based Point Shear Wave Elastography for Differential Diagnosis of Pancreatic Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-1766","authenticated-orcid":false,"given":"Bozhidar","family":"Hristov","sequence":"first","affiliation":[{"name":"Second Department of Internal Diseases, Section \u201cGastroenterology\u201d, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"},{"name":"Gastroenterology Clinic, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Andonov","sequence":"additional","affiliation":[{"name":"Second Department of Internal Diseases, Section \u201cGastroenterology\u201d, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"},{"name":"Gastroenterology Clinic, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Doykov","sequence":"additional","affiliation":[{"name":"Second Department of Internal Diseases, Section \u201cGastroenterology\u201d, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"},{"name":"Gastroenterology Clinic, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tsvetkova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-7970","authenticated-orcid":false,"given":"Katya","family":"Doykova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"},{"name":"Department of Diagnostic Imaging, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-8397","authenticated-orcid":false,"given":"Mladen","family":"Doykov","sequence":"additional","affiliation":[{"name":"Department of Urology and General Medicine, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, Bulgaria"},{"name":"Clinic of Urology, University Hospital \u201cKaspela\u201d, 4001 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.21037\/tgh.2019.06.02","article-title":"Pathology of pancreatic cancer","volume":"4","author":"Haeberle","year":"2019","journal-title":"Transl. 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