{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:33:11Z","timestamp":1790242391885,"version":"4.1.0"},"reference-count":11,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Mucosal prolapse syndrome is also known as solitary rectal ulcer syndrome. It may either presents as an ulcer or polyp, which could mimic other pathological lesions such as juvenile polyp, hyperplastic polyp, adenomatous polyp, polyp related inflammatory bowel disease and adenocarcinoma. It can pose as a diagnostic challenge to both the surgeons and pathologists due to the overlapping gross and histological features. The characteristic histological features of mucosal prolapse syndrome are fibromuscular obliteration of lamina propria and splayed hypertrophic muscularis mucosae. It can occur in a wide range of ages, including children and teenagers. Rectal bleeding is one of the common presenting symptoms. Here, we described two cases of mucosal prolapse syndrome presented as rectal polyposis and provide a discussion on its histological differential diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics12040966","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:15:35Z","timestamp":1649798135000},"page":"966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rectal Polyposis in Mucosal Prolapse Syndrome"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-9927","authenticated-orcid":false,"given":"Yin Ping","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Kabincong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Faisal","family":"Jabar","sequence":"additional","affiliation":[{"name":"Prince Court Medical Centre, Jalan Kia Peng, Kuala Lumpur 50450, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2289-7619","authenticated-orcid":false,"given":"Geok Chin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"},{"name":"Prince Court Medical Centre, Jalan Kia Peng, Kuala Lumpur 50450, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000450900","article-title":"Solitary Rectal Ulcer Syndrome: A Paediatric Case Report","volume":"24","author":"Abreu","year":"2017","journal-title":"GE Port. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2559.2006.02552.x","article-title":"Histopathological mimicry in mucosal prolapse","volume":"50","author":"Singh","year":"2007","journal-title":"Histopathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00384-005-0020-6","article-title":"Solitary rectal ulcer syndrome: An endoscopic and histological presentation and literature review","volume":"21","author":"Chiang","year":"2006","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_4","unstructured":"Cruveilhier, J. (1829). Ulcere chronique du rectum. Anatomie Pathologique du Corps Humain, JB Bailliere."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13256-021-02857-8","article-title":"Inflammatory cap polyp of the sigmoid colon: A case report","volume":"15","author":"Pandit","year":"2021","journal-title":"J. Med. Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02051012","article-title":"Clinical conundrum of solitary rectal ulcer","volume":"35","author":"Tjandra","year":"1992","journal-title":"Dis Colon Rectum"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/jcp.2009.067801","article-title":"Mucosal prolapse syndrome presenting as rectal polyposis","volume":"62","author":"Brosens","year":"2009","journal-title":"J. Clin. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3748\/wjg.v20.i3.738","article-title":"Solitary rectal ulcer syndrome: Clinical features, pathophysiology, diagnosis and treatment strategies","volume":"20","author":"Zhu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_9","first-page":"399","article-title":"Solitary rectal ulcer syndrome in children and adolescents: A descriptive clinicopathologic study","volume":"14","author":"Abusharifah","year":"2021","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/gut.34.1.106","article-title":"Microvascular abnormalities in the mucosal prolapse syndrome","volume":"34","author":"Lonsdale","year":"1993","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fped.2020.00396","article-title":"A Clinical Entity Often Missed-Solitary Rectal Ulcer Syndrome in Children","volume":"8","author":"Thirumal","year":"2020","journal-title":"Front. Pediatr."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/4\/966\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:52:38Z","timestamp":1760136758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/4\/966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["diagnostics12040966"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12040966","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}