{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:40:17Z","timestamp":1769092817310,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this study is to propose a clinical method to evaluate myalgia in respiratory settings as a possible tool for the recognition of MSA\/MAA positivity in ILD patients. We prospectively enrolled 167 ILD patients with suspected myositis, of which 63 had myalgia evoked at specific points (M+ILD+). We also enrolled in a 174 patients with only myalgia (M+ILD-) in a rheumatological setting. The patients were assessed jointly by rheumatologists and pulmonologists and were tested for autoantibodies. M+ILD+ patients were positive for at least one MAA\/MSA in 68.3% of cases, as were M-ILD+ patients in 48.1% of cases and M+ILD- patients in 17.2% of cases (p = 0.01 and &lt;0.0001, respectively). A diagnosis of IIM was made in 39.7% of M+ILD+ patients and in 23.1% of the M-ILD+ group (p = 0.02). Myalgia was significantly associated with positivity for MSA\/MAAs in ILD patients (p = 0.01, X2: 6.47). In conclusion, myalgia in ILD patients with suspected myositis is associated with MSA\/MAA positivity, and could support a diagnosis of IIM. A significant proportion of M+ILD- patients also had MSA\/MAA positivity, a phenomenon warranting further study to evaluate its clinical meaning.<\/jats:p>","DOI":"10.3390\/diagnostics12051139","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T10:49:30Z","timestamp":1651661370000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-1202","authenticated-orcid":false,"given":"Gianluca","family":"Sambataro","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"},{"name":"Outpatient Clinic of Rheumatology, Artroreuma S.R.L., Corso S. Vito 53, 95030 Mascalucia (CT), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara Alfia","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Spadaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano Emanuele","family":"Torrisi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Vignigni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8587-9151","authenticated-orcid":false,"given":"Giuseppe","family":"Muscato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-8852","authenticated-orcid":false,"given":"Nicoletta","family":"Del Papa","sequence":"additional","affiliation":[{"name":"Day Hospital of Rheumatology, Department of Rheumatology, ASST G.Pini-CTO, Piazza Cardinal Ferrari 1, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-3404","authenticated-orcid":false,"given":"Michele","family":"Colaci","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, Via Messina 829, 95100 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-2729","authenticated-orcid":false,"given":"Lorenzo","family":"Malatino","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Department of Clinical and Experimental Medicine, Cannizzaro Hospital, University of Catania, Via Messina 829, 95100 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-2974","authenticated-orcid":false,"given":"Stefano","family":"Palmucci","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Sciences and Advanced Technologies, \u201cG.F. Ingrassia\u201d, University of Catania, Via S. Sofia 68 Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-1528","authenticated-orcid":false,"given":"Lorenzo","family":"Cavagna","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Piazzale C. Golgi 19, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-1282","authenticated-orcid":false,"given":"Giovanni","family":"Zanframundo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Piazzale C. Golgi 19, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Via Roma 24, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Baldini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Via Roma 24, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Outpatient Clinic of Rheumatology, Artroreuma S.R.L., Corso S. Vito 53, 95030 Mascalucia (CT), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Disease, A.O.U. \u201cPoliclinico-San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMra2005230","article-title":"Spectrum of Fibrotic Lung Diseases","volume":"383","author":"Wijsenbeek","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/157339710791330740","article-title":"Interstitial Lung Disease in Idiopathic Inflammatory Myopathy","volume":"6","author":"Saketoo","year":"2020","journal-title":"Curr. 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