{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:26:57Z","timestamp":1790810817642,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Gastric cancer is a global health problem. The pathogenesis of this disease remains unclear. This study included 198 H. pylori (+) men aged 45 to 60 years old. Group A included 63 practically healthy men, group B included 45 men with severe atrophic body gastritis, group C included 37 men with epithelial gastric cancer stages I\u2013II according to TNM, and group D included 54 men with epithelial gastric cancer stages III\u2013IV according to the TNM scale. The content of malondialdehyde (MDA), diene conjugates (DCs), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPO) was detected using an enzyme immunoassay (ELISA) or spectrophotometric methods in the blood plasma. The concentrations of MDA and DC were increased in the patients of group B compared with group A, and in patients of groups C and D compared with groups A and B. The ratio of MDA\/SOD and MDA\/CAT was decreased in the patients in group D compared with the patients in group C, and was significantly higher compared with group A. The ratios of MDA\/GPO and MDA\/GST increased linearly and were at a maximum in groups C and D. Our work determined that indicators of oxidative stress may be the biochemical substrate, which brings together the various stages of the Correa cascade, and may explain disease progression. The dynamics of changes in the content of SOD and CAT in the plasma in patients with gastric cancer may be a target of future investigations.<\/jats:p>","DOI":"10.3390\/diagnostics12051203","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:19:46Z","timestamp":1652264386000},"page":"1203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dynamics of Oxidative Stress in Helicobacter pylori-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-2294","authenticated-orcid":false,"given":"Vladislav Vladimirovich","family":"Tsukanov","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Valentinovna","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Vilyamovich","family":"Kasparov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-1893","authenticated-orcid":false,"given":"Alexander Alexandrovich","family":"Sinyakov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Viktorovich","family":"Vasyutin","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Leongardovna","family":"Tonkikh","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail Alexandrovich","family":"Cherepnin","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Medical Problems of the North, Federal Research Centre \u201cKrasnoyarsk Science Centre\u201d of the Siberian Branch of Russian Academy of Science, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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