{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:21:13Z","timestamp":1789154473757,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation (DFG)","award":["433849769"],"award-info":[{"award-number":["433849769"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Chronic osteomyelitis (OM) is a progressive but mostly low-grade infection of the bones. The management of this disease is highly challenging for physicians. Despite systematic treatment approaches, recurrence rates are high. Further, functional and patient-reported outcome data are lacking, especially after osseous defects are filled with bioresorbable antibiotic carriers. Objective: To assess functional and patient-reported outcome measures (PROM) following the administration of Cerament\u00ae G or V due to corticomedullary defects in chronic OM. Methods: We conducted a retrospective study from 2015 to 2020, including all patients who received Cerament\u00ae for the aforementioned reason. Patients were diagnosed and treated in accordance with globally valid recommendations, and corticomedullary defects were filled with Cerament\u00ae G or V, depending on the expected germ spectrum. Patients were systematically followed up, and outcome measures were collected during outpatient clinic visits. Results: Twenty patients with Cierny and Mader type III OM were included in this study and followed up for 20.2 \u00b1 17.2 months (95%CI 12.1\u201328.3). Ten of these patients needed at least one revision (2.0 \u00b1 1.3 revisions per patient (95%CI 1.1\u20132.9) during the study period due to OM persistence or local wound complications. There were no statistically significant differences in functional scores or PROMs between groups. Conclusion: The use of Cerament\u00ae G and V in chronic OM patients with corticomedullary defects appears to have good functional outcomes and satisfactory PROMs. However, the observed rate of local wound complications and the OM persistence rate may be higher when compared to previously published data.<\/jats:p>","DOI":"10.3390\/diagnostics12051207","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:19:46Z","timestamp":1652264386000},"page":"1207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Outcome Analysis of the Use of Cerament\u00ae in Patients with Chronic Osteomyelitis and Corticomedullary Defects"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-3089","authenticated-orcid":false,"given":"Marcel","family":"Niemann","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"},{"name":"Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-9059","authenticated-orcid":false,"given":"Frank","family":"Graef","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufian S.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"},{"name":"Department of Orthopedic Surgery, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-7201","authenticated-orcid":false,"given":"Karl F.","family":"Braun","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"},{"name":"Department of Trauma Surgery, University Hospital Rechts der Isar, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"St\u00f6ckle","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-2521","authenticated-orcid":false,"given":"Andrej","family":"Trampuz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Meller","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery, Charite\u0301-Universita\u0308tsmedizin Berlin, Corporate Member of Freie Universita\u0308t Berlin, Humboldt-Universita\u0308t zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jor.2016.10.004","article-title":"Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies","volume":"14","author":"Birt","year":"2017","journal-title":"J. Orthop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1086\/516149","article-title":"Staging and staging application in osteomyelitis","volume":"25","author":"Mader","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.7150\/jbji.34452","article-title":"Surgical Treatment and Outcomes of Calcaneal Osteomyelitis in Adults: A Systematic Review","volume":"4","author":"Sigmund","year":"2019","journal-title":"J. Bone Jt. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1302\/0301-620X.98B4.37883","article-title":"Decision-making in infected nonunion: Is the surgery more important than the condition?","volume":"98","author":"McNally","year":"2016","journal-title":"Bone Joint. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10856-020-06418-1","article-title":"Comparative osteoconductivity of bone void fillers with antibiotics in a critical size bone defect model","volume":"31","author":"Oliver","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1302\/0301-620X.96B6.32244","article-title":"The treatment of intramedullary osteomyelitis of the femur and tibia using the Reamer-Irrigator-Aspirator system and antibiotic cement rods","volume":"96","author":"Kanakaris","year":"2014","journal-title":"Bone Jt. J."},{"key":"ref_7","first-page":"e20969","article-title":"Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in the Management of Patients with Traumatic Bone Voids","volume":"14","author":"Aljawadi","year":"2022","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Freischmidt, H., Armbruster, J., Bonner, E., Guehring, T., Nurjadi, D., Bechberger, M., Sonntag, R., Schmidmaier, G., Gr\u00fctzner, P.A., and Helbig, L. (2021). Systemic Administration of PTH Supports Vascularization in Segmental Bone Defects Filled with Ceramic-Based Bone Graft Substitute. Cells, 10.","DOI":"10.3390\/cells10082058"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.foot.2019.01.005","article-title":"Adjuvant antibiotic loaded bio composite in the management of diabetic foot osteomyelitis\u2014A multicentre study","volume":"39","author":"Niazi","year":"2019","journal-title":"Foot"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1302\/0301-620X.98B9.38057","article-title":"Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate\/hydroxyapatite biocomposite: A prospective series of 100 cases","volume":"98","author":"McNally","year":"2016","journal-title":"Bone Joint J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1302\/0301-620X.102B11.BJJ-2020-0284.R1","article-title":"Can we predict outcome after treatment of long bone osteomyelitis?","volume":"102","author":"Hotchen","year":"2020","journal-title":"Bone Joint J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/heartjnl-2013-304588","article-title":"Validity of Charlson Comorbidity Index in patients hospitalised with acute coronary syndrome. Insights from the nationwide AMIS Plus registry 2002\u20132012","volume":"100","author":"Radovanovic","year":"2014","journal-title":"Heart"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.mporth.2010.09.004","article-title":"Osteomyelitis","volume":"24","author":"McNally","year":"2010","journal-title":"Orthop. Trauma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1002\/acr.20630","article-title":"Measures of adult shoulder function: Disabilities of the Arm, Shoulder, and Hand Questionnaire (DASH) and its short version (QuickDASH), Shoulder Pain and Disability Index (SPADI), American Shoulder and Elbow Surgeons (ASES) Society standardized shoulder assessment form, Constant (Murley) Score (CS), Simple Shoulder Test (SST), Oxford Shoulder Score (OSS), Shoulder Disability Questionnaire (SDQ), and Western Ontario Shoulder Instability Index (WOSI)","volume":"63","author":"Angst","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11999-016-4886-0","article-title":"Can Original Knee Society Scores Be Used to Estimate New 2011 Knee Society Scores?","volume":"475","author":"Odum","year":"2017","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00167-017-4748-7","article-title":"Measurement properties of the most commonly used Foot- and Ankle-Specific Questionnaires: The FFI, FAOS and FAAM. A systematic review","volume":"26","author":"Sierevelt","year":"2018","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.2106\/JBJS.O.00030","article-title":"Scoring the SF-36 in Orthopaedics: A Brief Guide","volume":"97","author":"Laucis","year":"2015","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5194\/jbji-6-151-2021","article-title":"A retrospective cohort study comparing clinical outcomes and healthcare resource utilisation in patients undergoing surgery for osteomyelitis in England: A case for reorganising orthopaedic infection services","volume":"6","author":"Ferguson","year":"2021","journal-title":"J. Bone Jt. Infect."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Del Pozo, E.G., Collazos, J., Carton, J.A., Camporro, D., and Asensi, V. (2018). Factors predictive of relapse in adult bacterial osteomyelitis of long bones. 11 Medical and Health Sciences 1103 Clinical Sciences. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3550-6"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s13018-019-1388-2","article-title":"A systematic review of the single-stage treatment of chronic osteomyelitis","volume":"14","author":"Pincher","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1186\/s13063-019-3832-3","article-title":"Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): A randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy","volume":"20","author":"Dudareva","year":"2019","journal-title":"Trials"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9343(03)00231-6","article-title":"Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy","volume":"114","author":"Tice","year":"2003","journal-title":"Am. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7150\/jbji.31764","article-title":"The Effect of Age on Outcome in Excision of Chronic Osteomyelitis with Free Muscle Flap Reconstruction","volume":"4","author":"Kendall","year":"2019","journal-title":"J. Bone Jt. Infect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0002-9610(03)00292-7","article-title":"Surgical management of chronic osteomyelitis","volume":"188","author":"Parsons","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00003086-199310000-00007","article-title":"Gentamicin-impregnated polymethylmethacrylate beads compared with systemic antibiotic therapy in the treatment of chronic osteomyelitis","volume":"295","author":"Evans","year":"1993","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13018-022-02980-2","article-title":"Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: A systematic review and meta-analysis","volume":"17","author":"Shi","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1302\/0301-620X.91B8.22216","article-title":"Locally-administered antibiotics in wounds in a limb","volume":"91","author":"Branstetter","year":"2009","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5194\/jbji-6-283-2021","article-title":"Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis","volume":"6","author":"Dvorzhinskiy","year":"2021","journal-title":"J. Bone Jt. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15384","DOI":"10.1038\/s41598-018-33736-w","article-title":"Early Clinical and Radiological Experience with a Ceramic Bone Graft Substitute in the Treatment of Benign and Borderline Bone Lesions","volume":"8","author":"Horstmann","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7150\/jbji.31592","article-title":"Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis","volume":"4","author":"Ferguson","year":"2019","journal-title":"J. Bone Jt. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7150\/jbji.17586","article-title":"Calcium-Based, Antibiotic-Loaded Bone Substitute as an Implant Coating: A Pilot Clinical Study","volume":"1","author":"Logoluso","year":"2016","journal-title":"J. Bone Jt. Infect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/BPB.0000000000000517","article-title":"Tobramycin-impregnated calcium sulfate pellets for the treatment of chronic osteomyelitis in children and adolescents","volume":"28","author":"Andreacchio","year":"2019","journal-title":"J. Pediatr. Orthop. Part B"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00005131-200210000-00002","article-title":"The Use of an Antibiotic-Impregnated, Osteoconductive, Bioabsorbable Bone Substitute in the Treatment of Infected Long Bone Defects: Early Results of a Prospective Trial","volume":"16","author":"McKee","year":"2002","journal-title":"J. Orthop. Trauma"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/230949900201000110","article-title":"The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant","volume":"10","author":"Gitelis","year":"2002","journal-title":"J. Orthop. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.joms.2016.06.178","article-title":"Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw","volume":"75","author":"Sun","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1821833","DOI":"10.21037\/apm.2020.03.23","article-title":"The effect of calcium sulfate\/calcium phosphate composite for the treatment of chronic osteomyelitis compared with calcium sulfate","volume":"9","author":"Zhao","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7150\/jbji.20404","article-title":"Treatment of Cavitary Bone Defects in Chronic Osteomyelitis: Bioactive glass S53P4 vs. Calcium Sulphate Antibiotic Beads","volume":"2","author":"Ferrando","year":"2017","journal-title":"J. Bone Jt. Infect."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11751-014-0206-y","article-title":"Adjuvant treatment of chronic osteomyelitis of the tibia following exogenous trauma using OSTEOSET \u00d2-T: A review of 21 patients in a regional trauma centre","volume":"9","author":"Humm","year":"2014","journal-title":"Strateg. Trauma Limb Reconstr."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/5\/1207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:09:27Z","timestamp":1760137767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/5\/1207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["diagnostics12051207"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12051207","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]}}}