{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:56:45Z","timestamp":1785869805500,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Development program of ETU \u201cLETI\u201d within the framework of the program of strategic academic leadership","award":["075-15-2021-1318"],"award-info":[{"award-number":["075-15-2021-1318"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Isolated sphenoid sinusitis (ISS) is a group of pathologies characterized by inflammation in one or both sphenoid sinuses. The gold standard for analyzing and diagnosing ISS is computer tomography. Many researchers have discussed the treatment of patients with ISS variants such as fully opacified sinus, mostly with surgery. A retrospective analysis of clinical data of 59 patients (21 male (35%), 38 female (65%)) with ISS, who were treated in the Otorhinolaryngological Department of Pavlov First Saint Petersburg State Medical University between January 2017 and January 2020, was conducted. All patients were in the first stage of the same medical therapy. In cases where there was no recovery, these patients were referred to surgery. For the control group, we analyzed patients without any disorders according to CT-scan examination. After analyzing the obtained clinical and radiological data, we found indicators that were common in patients who did not recover after medical therapy. According to the reverse regression method statistical model, in male patients with a diffuse headache and nasal discharge it was shown that medical therapy was highly effective (more than 78%). The presence of nasal septum deviation and adenoids in male and female patients leads to the highest risk of surgical treatment (83% probability of the logistic model). The detailed analysis of CT-scans and the complaints of patients with ISS can be the key to determining the preferred therapy choice. Not all cases need to have an endoscopic opening of the sphenoid sinus, according to our research.<\/jats:p>","DOI":"10.3390\/diagnostics12051284","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"1284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Isolated Sphenoid Sinusitis: Anatomical Features for Choosing a Method of Treatment, a Case-Control Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Sergei","family":"Karpishchenko","sequence":"first","affiliation":[{"name":"ENT Department with Clinic, Pavlov First Saint Petersburg State Medical University, 195176 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vereshchagina","sequence":"additional","affiliation":[{"name":"ENT Department with Clinic, Pavlov First Saint Petersburg State Medical University, 195176 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7992","authenticated-orcid":false,"given":"Olga","family":"Stancheva","sequence":"additional","affiliation":[{"name":"ENT Department with Clinic, Pavlov First Saint Petersburg State Medical University, 195176 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-4363","authenticated-orcid":false,"given":"Tatiana","family":"Nagornykh","sequence":"additional","affiliation":[{"name":"ENT Department with Clinic, Pavlov First Saint Petersburg State Medical University, 195176 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Krasichkov","sequence":"additional","affiliation":[{"name":"Radio Engineering Systems Department, Saint Petersburg Electrotechnical University \u201cLETI\u201d, 197022 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-7375","authenticated-orcid":false,"given":"Irina","family":"Serdiukova","sequence":"additional","affiliation":[{"name":"Radio Engineering Systems Department, Saint Petersburg Electrotechnical University \u201cLETI\u201d, 197022 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-4909","authenticated-orcid":false,"given":"Aleksandr","family":"Sinitca","sequence":"additional","affiliation":[{"name":"Research Centre for Digital Telecommunication Technologies, Saint Petersburg Electrotechnical University \u201dLETI\u201d, 197022 St. Petersburg, Russia"},{"name":"Faculty of Information Technologies, Kazakh-British Technical University, Almaty 050000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-4509","authenticated-orcid":false,"given":"Dmitry","family":"Kaplun","sequence":"additional","affiliation":[{"name":"Faculty of Information Technologies, Kazakh-British Technical University, Almaty 050000, Kazakhstan"},{"name":"Department of Automation and Control Processes, Saint Petersburg Electrotechnical University \u201cLETI\u201d, 197022 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archotol.126.6.777","article-title":"Isolated sphenoid sinus diseases: Report of 39 cases","volume":"126","author":"Ruoppi","year":"2000","journal-title":"Arch. Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.amjoto.2009.10.005","article-title":"Sphenoid sinus barotrauma after free diving","volume":"32","author":"Bourolias","year":"2011","journal-title":"Am. J. Otolaryngol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/archotol.128.12.1413","article-title":"Evaluation and Surgical Management of Isolated Sphenoid Sinus Disease","volume":"128","author":"Martin","year":"2002","journal-title":"Arch. Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3389\/fneur.2018.00745","article-title":"Headache secondary to isolated sphenoid sinus fungus ball: Retrospective analysis of 6 cases first diagnosed in the neurology department","volume":"9","author":"Gao","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1080\/00016480701793735","article-title":"Diagnosis and treatment of isolated sphenoid sinus disease: A review of 109 cases","volume":"128","author":"Socher","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0030-6665(03)00160-9","article-title":"Isolated sphenoid sinus disease","volume":"37","author":"Grillone","year":"2004","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00405-004-0764-6","article-title":"Endoscopic treatment of the isolated sphenoid sinus lesions","volume":"262","author":"Castelnuovo","year":"2005","journal-title":"Eur. Arch. Oto-Rhino-Laryngol. Head Neck"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.otohns.2005.04.013","article-title":"What is the relationship between chronic sinus disease and isolated nasal septal deviation?","volume":"133","author":"Yasan","year":"2005","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/alr.21908","article-title":"Computational fluid dynamic modeling of nose-to-ceiling head positioning for sphenoid sinus irrigation","volume":"7","author":"Craig","year":"2017","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.otohns.2006.11.019","article-title":"The clinical behavior of isolated sphenoid sinusitis","volume":"136","author":"Gilony","year":"2007","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/hed.2880160507","article-title":"Functional endoscopic sinus surgery for isolated sphenoid sinus disease","volume":"16","author":"Gilain","year":"1994","journal-title":"Head Neck"},{"key":"ref_12","first-page":"2","article-title":"Isolated Sphenoid Sinus Disease: The MERF Experience","volume":"9","author":"Natarajan","year":"2019","journal-title":"Otolarygol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/00016480701762466","article-title":"Isolated sphenoid sinus diseases: Report of 76 cases","volume":"128","author":"Whan","year":"2008","journal-title":"Acta Oto-Laryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.otohns.2005.04.023","article-title":"Isolated Sphenoid Sinus Disease: Etiology and Management","volume":"133","author":"Friedman","year":"2005","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0735-6757(93)90133-V","article-title":"Isolated sphenoid sinusitis","volume":"11","author":"Goldman","year":"1993","journal-title":"Am. J. Emerg. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0733-8619(03)00091-4","article-title":"Headaches due to nasal and paranasal sinus disease","volume":"22","author":"Silberstein","year":"2004","journal-title":"Neurol. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ijporl.2003.11.011","article-title":"Isolated sphenoid sinusitis presenting with unilateral VIth nerve palsy","volume":"68","author":"Ada","year":"2004","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ejrad.2008.01.059","article-title":"Paranasal sinus imaging","volume":"66","author":"Maroldi","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"ref_19","first-page":"689","article-title":"Endoscopic sinus surgery for solitary abducens palsy in patients with isolated sphenoid sinus disease: Report of four cases","volume":"25","author":"Lee","year":"2002","journal-title":"Chang. Gung Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Karpishchenko, S., Arustamyan, I., Stancheva, O., Sharko, K., Kaplun, D., and Bogachev, M.I. (2020). Intraoperative Sphenoid Sinus Volume Measurement as an Alternative Technique to Intraoperative Computer Tomography. Diagnostics, 10.","DOI":"10.3390\/diagnostics10060350"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stancheva, O.A., Gindryuk, A.F., Kaplun, D.I., Sinitca, A.M., Efimenko, G.A., and Tselobanov, N. (2021, January 21\u201323). Mobile Application-based Approach for the Measuring of Internal Nasal Structures. Proceedings of the 2021 IV International Conference on Control in Technical Systems (CTS), St. Petersburg, Russia.","DOI":"10.1109\/CTS53513.2021.9562896"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01794761","article-title":"Radiologic anatomy of the paranasal sinuses in the child","volume":"14","author":"Weiglein","year":"1992","journal-title":"Surg. Radiol. Anat."},{"key":"ref_23","first-page":"17","article-title":"CT study of the sphenoid sinus pneumatization types","volume":"2","author":"Baldea","year":"2012","journal-title":"Rom. J. Rhinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00357-019-09345-1","article-title":"ROC and AUC with a Binary Predictor: A Potentially Misleading Metric","volume":"37","author":"Muschelli","year":"2020","journal-title":"J. Classif."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kamarudin, A.N., Cox, T., and Kolamunnage-Dona, R. (2017). Time-dependent ROC curve analysis in medical research: Current methods and applications. BMC Med. Res. Methodol., 17.","DOI":"10.1186\/s12874-017-0332-6"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2288-14-26","article-title":"A modified Wald interval for the area under the ROC curve (AUC) in diagnostic case-control studies","volume":"14","author":"Kottas","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/sim.2358","article-title":"Tests of equivalence and non-inferiority for diagnostic accuracy based on the paired areas under ROC curves","volume":"25","author":"Liu","year":"2006","journal-title":"Stat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jelekin.2018.12.006","article-title":"Logistic regression analysis of multiple interosseous hand-muscle activities using surface electromyography during finger-oriented tasks","volume":"44","author":"Yokoyama","year":"2019","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"De Cock, M., Dowsley, R., Nascimento, A.C.A., Railsback, D., Shen, J., and Todoki, A. (2021). High performance logistic regression for privacy-preserving genome analysis. BMC Med. Genom., 14.","DOI":"10.1186\/s12920-020-00869-9"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/sim.4780140806","article-title":"Logistic regression in case-control studies: The effect of using independent as dependent variables","volume":"14","author":"Nagelkerke","year":"1995","journal-title":"Stat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.otohns.2008.04.020","article-title":"Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation","volume":"139","author":"Harvey","year":"2008","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/alr.22371","article-title":"Effects of sphenoid surgery on nasal irrigation delivery","volume":"9","author":"Grayson","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.anl.2012.07.008","article-title":"Clinical characteristics and outcome in patients with isolated sphenoid sinus aspergilloma","volume":"40","author":"Jung","year":"2013","journal-title":"Auris Nasus Larynx"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1097\/00005537-199712000-00003","article-title":"Isolated sphenoid sinus disease: An analysis of 132 cases","volume":"107","author":"Lawson","year":"1997","journal-title":"Laryngoscope"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/5\/1284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:16:11Z","timestamp":1760138171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/5\/1284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,21]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["diagnostics12051284"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12051284","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,21]]}}}