{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:04:37Z","timestamp":1792803877239,"version":"4.5.0"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cooperatio program, Maternal and Childhood Care-Neonatology, Charles University Prague, Czech Republic","award":["00064203"],"award-info":[{"award-number":["00064203"]}],"id":[{"id":"https:\/\/ror.org\/024d6js02","id-type":"ROR","asserted-by":"crossref"}]},{"name":"MH CZ-DRO, University Hospital Motol, Prague, Czech Republic","award":["00064203"],"award-info":[{"award-number":["00064203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The aim of this study was to assess the applicability of the neonatal sequential organ failure assessment score (nSOFA) within 72 h after delivery as a predictor for mortality and adverse outcome in very preterm neonates. Inborn neonates &lt;32 weeks of gestation were evaluated. The nSOFA scores were calculated from medical records in the first 72 h after birth and the peak value was used for analysis. Death or composite morbidity at hospital discharge defined the adverse outcome. Composite morbidity consisted of chronic lung disease, intraventricular haemorrhage \u2265grade III, periventricular leukomalacia and necrotizing enterocolitis. Among 423 enrolled infants (median birth weight 1070 g, median gestational age 29 weeks), 27 died and 91 developed composite morbidity. Death or composite morbidity was associated with organ dysfunction as assessed by nSOFA, systemic inflammatory response, and low birthweight. The score &gt;2 was associated with OR 2.5 (CI 1.39\u20134.64, p = 0.002) for the adverse outcome. Area under the curve of ROC was 0.795 (95% CI = 0.763\u20130.827). The use of nSOFA seems to be reasonable for predicting mortality and morbidity in very preterm infants. It constitutes a suitable basis to measure the severity of organ dysfunction regardless of the cause.<\/jats:p>","DOI":"10.3390\/diagnostics12061342","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:50:51Z","timestamp":1653814251000},"page":"1342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9479","authenticated-orcid":false,"given":"Ivan","family":"Berka","sequence":"first","affiliation":[{"name":"Institute for the Care of Mother and Child, 14700 Prague, Czech Republic"},{"name":"Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kor\u010dek","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child, 14700 Prague, Czech Republic"},{"name":"Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Janota","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Obstetrics and Gynecology, Second Faculty of Medicine, Motol University Hospital, Charles University\u2014Prague, V Uvalu 84, 15000 Prague, Czech Republic"},{"name":"Institute of Pathological Physiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 12853 Prague, Czech Republic"},{"name":"Department of Neonatology, Thomayer Hospital Prague, Videnska 800, 14059 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-3198","authenticated-orcid":false,"given":"Zbyn\u011bk","family":"Stra\u0148\u00e1k","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child, 14700 Prague, Czech Republic"},{"name":"Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e164396","DOI":"10.1001\/jamapediatrics.2016.4396","article-title":"Variation in Performance of Neonatal Intensive Care Units in the United States","volume":"171","author":"Horbar","year":"2017","journal-title":"JAMA Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104521","DOI":"10.1016\/j.compbiomed.2021.104521","article-title":"Hybridized Neural Networks for Non-invasive and Continuous Mortality Risk Assessment in Preterm Infants","volume":"134","author":"Baker","year":"2021","journal-title":"Comput. 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