{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:52:10Z","timestamp":1777657930837,"version":"3.51.4"},"reference-count":90,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In 1921; Masson and Maresch first coined the term \u201cneurogenic appendicitis (NA)\u201d to describe \u201cneuroma-like\u201d lesions in the appendix. To date, our knowledge about NA is limited; therefore, we conducted a comprehensive analysis of the literature (1921 to 2020) to examine the clinicopathological features of NA. We also addressed the pathophysiology of acute abdominal pain and fibrosis in this entity. We performed a meta-analysis study by searching the PubMed database, using several keywords, such as: \u201cappendix,\u201d \u201cneurogenic,\u201d \u201cobliterative,\u201d \u201cneuroma,\u201d \u201cfibrous obliteration,\u201d \u201cappendicopathy,\u201d and \u201cappendicitis.\u201d Our study revealed that patients with NA usually present clinically with features of acute appendicitis, bud2t they have grossly unremarkable appendices. Histologically, the central appendiceal neuroma was the most common histological variant of NA, followed by the submucosal and intramucosal variants. To conclude, NA represents a form of neuroinflammation. The possibility of NA should be considered in patients with clinical features of acute appendicitis who intraoperatively show a grossly unremarkable appendix. Neuroinflammation and neuropeptides play roles in the development of pain and fibrosis in NA.<\/jats:p>","DOI":"10.3390\/diagnostics12061386","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T09:42:32Z","timestamp":1654335752000},"page":"1386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis"],"prefix":"10.3390","volume":"12","author":[{"given":"Mahmoud Rezk Abdelwahed","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Pathology, Assiut University Hospitals, Assiut 71515, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-7226","authenticated-orcid":false,"given":"Ali","family":"Al Bshabshe","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, King Khalid University, Abha 62527, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdelsatar","family":"Elhakeem","sequence":"additional","affiliation":[{"name":"Department of Pathology, Alazhar University, Cairo 11884, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-8954","authenticated-orcid":false,"given":"Mahmoud Kamal","family":"Elsamman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82725, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"ref_1","first-page":"293","article-title":"Investigation and analysis of the position, fixation, length and embryology of the vermiform appendix","volume":"139","author":"Buschard","year":"1973","journal-title":"Acta Chir. 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