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The study included 24 subjects (all male; age: 28.16 \u00b1 7.10 years; height: 1.75 \u00b1 0.04 m; weight: 70.62 \u00b1 4.70 kg). A Vicon three-dimensional analysis system and a force plate were used to collect lower extremity kinematic and kinetic data from the participants before and after walking training under various walking situations. Least-squares linear regression equations were utilized to evaluate joint stiffness during single-leg support. Three velocities significantly affected the stiffness of the knee and hip joint (p &lt; 0.001), with a positive correlation. However, ankle joint stiffness was significantly lower only at maximum speed (p &lt; 0.001). Hip stiffness was significantly higher after walking training than that before training (p &lt; 0.001). In contrast, knee stiffness after training was significantly lower than pre-training stiffness in the same walking condition (p &lt; 0.001). Ankle stiffness differed only at maximum speed, and it was significantly higher than pre-training stiffness (p &lt; 0.001). Walking fatigue appeared to change the mechanical properties of the joint. Remarkably, at the maximum walking velocity in exhaustion, when the load on the hip joint was significantly increased, the knee joint\u2019s stiffness decreased, possibly leading to joint instability that results in exercise injury.<\/jats:p>","DOI":"10.3390\/diagnostics12061470","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:17:01Z","timestamp":1655331421000},"page":"1470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Fatigue on Lower Limb Joint Stiffness at Different Walking Speeds"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-463X","authenticated-orcid":false,"given":"Enze","family":"Shao","sequence":"first","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7705-8134","authenticated-orcid":false,"given":"Zhenghui","family":"Lu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-7670","authenticated-orcid":false,"given":"Xuanzhen","family":"Cen","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"},{"name":"Doctoral School on Safety and Security Sciences, Obuda University, 1034 Budapest, Hungary"},{"name":"Faculty of Engineering, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"ANTA Sports Science Laboratory, ANTA (China) Co., Ltd., Xiamen 361008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-5668","authenticated-orcid":false,"given":"Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-9440","authenticated-orcid":false,"given":"Yaodong","family":"Gu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/S1368980099000154","article-title":"Physical activity levels and body weight in a nationally representative sample in the European Union","volume":"2","author":"Afonso","year":"1999","journal-title":"Public Health Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5334\/paah.87","article-title":"Population-level Interventions Based on Walking and Cycling as a Means to Increase Physical Activity","volume":"5","author":"Ahmed","year":"2021","journal-title":"Phys. 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