{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:31:06Z","timestamp":1775694666751,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The management of patients with peripheral artery disease (PAD) is integrative and multidisciplinary, in which cardiac rehabilitation (CR) plays a prognostic role in terms of functional status, quality of life, and long-term impact on morbidity and mortality. We conducted a prospective cohort study on 97 patients with PAD admitted to a single tertiary referral center. Based on a prognostic index developed to stratify long-term mortality risk in PAD patients, we divided the cohort into two groups: low and low-intermediate risk group (45 cases) and high-intermediate and high risk group (52 cases). We analyzed demographics, clinical parameters, and paraclinical parameters in the two groups, as well as factors associated with cardiological reassessment prior to the established deadline of 6 months. Obesity (p = 0.048), renal dysfunction (p &lt; 0.001), dyslipidemia (p &lt; 0.001), tobacco use (p = 0.048), and diabetes mellitus (p &lt; 0.001) are comorbidities with long-term prognostic value. Low-density lipoprotein cholesterol (p = 0.002), triglycerides (p = 0.032), fasting glucose (p = 0.011), peak oxygen uptake (p = 0.005), pain-free walking distance (p = 0.011), maximum walking time (p &lt; 0.001), and maximum walking distance (p = 0.002) influence the outcome of PAD patients by being factors associated with clinical improvement at the 6-month follow-up. PAD patients benefit from enrollment in CR programs, improvement of clinical signs, lipid and carbohydrate profile, and weight loss and maintenance of blood pressure profile within normal limits, as well as increased exercise capacity being therapeutic targets.<\/jats:p>","DOI":"10.3390\/diagnostics12061500","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T01:43:27Z","timestamp":1655775807000},"page":"1500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac Rehabilitation and Mortality Risk Reduction in Peripheral Artery Disease at 6-Month Outcome"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-4347","authenticated-orcid":false,"given":"Razvan","family":"Anghel","sequence":"first","affiliation":[{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-3320","authenticated-orcid":false,"given":"Cristina Andreea","family":"Adam","sequence":"additional","affiliation":[{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-8565","authenticated-orcid":false,"given":"Ovidiu","family":"Mitu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Sf. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-9953","authenticated-orcid":false,"given":"Dragos Traian Marius","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-0918","authenticated-orcid":false,"given":"Viviana","family":"Onofrei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Sf. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Roca","sequence":"additional","affiliation":[{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-9904","authenticated-orcid":false,"given":"Alexandru Dan","family":"Costache","sequence":"additional","affiliation":[{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-6482","authenticated-orcid":false,"given":"Radu Stefan","family":"Miftode","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Sf. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigore","family":"Tinica","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Institute of Cardiovascular Diseases \u201dProf. Dr. George I.M. Georgescu\u201d, 700503 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-9327","authenticated-orcid":false,"given":"Florin","family":"Mitu","sequence":"additional","affiliation":[{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"},{"name":"Department of Internal Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s43044-021-00156-7","article-title":"Cardiac rehabilitation via telerehabilitation in COVID-19 pandemic situation","volume":"73","author":"Sari","year":"2021","journal-title":"Egypt. 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