{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:27:05Z","timestamp":1762057625602,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008431","name":"Gerencia Regional de Salud de Castilla y Le\u00f3n to JF","doi-asserted-by":"publisher","award":["GRS2164\/A\/2020","GRS2379\/A\/21"],"award-info":[{"award-number":["GRS2164\/A\/2020","GRS2379\/A\/21"]}],"id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Plantar fibromatosis, known as Ledderhose disease, is a neoplastic disease characterized by a locally-aggressive bland fibroblastic proliferation. Although Pacinian corpuscles alterations are commonly described in palmar fibromatosis, there are still no references about Pacinian corpuscles alterations in the rarer plantar version. Methods: We present a case report where a wide cutaneous resection, including the plantar fascia was performed, allowing a detailed study of Pacinian corpuscles. Pacinian corpuscles were analyzed using immunohistochemistry for neurofilament proteins, S100 protein, CD34, vimentin, glucose transporter 1, epithelial membrane antigen, neural-cell adhesion molecule, actin, desmin, type IV collagen, and high-affinity neurotrophin Trk-receptors. Moreover, the density and the size of the corpuscles were determined. Results: A clear increase in the number (hyperplasia) of Pacinian corpuscles was evidenced in the Ledderhose disease plantar fascia in comparison with similarly aged normal subjects. Pacinian hypertrophy was not demonstrated, but a significant decrease in the number of corpuscular lamellae was noted, with a subsequent increase in the interlamellar spaces. Pacinian corpuscles from the pathological plantar fascia showed an abnormal structure and immunohistochemical profile, generally without identifiable axons, and also absence of an inner core or an intermediate layer. Moreover, other molecules related with trophic maintenance of corpuscles were also absent. Finally, a vascular proliferation was commonly noted in some corpuscles, which involved all corpuscular constituents. Conclusion: The observed Pacinian corpuscles hyperplasia could be considered a diagnostic clue of plantar fibromatosis.<\/jats:p>","DOI":"10.3390\/diagnostics12071705","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:06:00Z","timestamp":1657749960000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pacinian Corpuscles as a Diagnostic Clue of Ledderhose Disease\u2014A Case Report and Mapping of Pacinian Corpuscles of the Sole"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-5332","authenticated-orcid":false,"given":"Jorge","family":"Feito","sequence":"first","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain"},{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-4514","authenticated-orcid":false,"given":"Ruth","family":"Esteban","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Lourdes","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Garc\u00eda-Alonso","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo, Hospital Universitario Rio Hortega, 47012 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Rodr\u00edguez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Bel\u00e9n","family":"Rivas-Marcos","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan L.","family":"Cobo","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjam\u00edn","family":"Mart\u00edn-Biedma","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda y Especialidades M\u00e9dico-Quir\u00fargicas, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Lahoz","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda e Histolog\u00eda, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia 7500912, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref_1","unstructured":"Glodblum, J.R., Folpe, A.L., and Weiss, S.W. 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