{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:02:02Z","timestamp":1760238122707,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Antiresorptive agent-related osteonecrosis of the jaw (ARONJ), a multifactorial disease, can drastically affect a patient\u2019s quality of life. Moreover, disease progression to severe acute inflammation can hinder treatment. Therefore, we aimed to investigate the diagnostic value of the neutrophil\u2013lymphocyte ratio (NLR) and platelet\u2013lymphocyte ratio (PLR) in predicting the risk of acute inflammation in patients with ARONJ. In total, 147 patients with ARONJ were enrolled between 1 January 2011 and 31 December 2019. They were divided into two groups according to their baseline NLR (high NLR vs. low NLR) or PLR (high PLR vs. low PLR) to analyze the relationship between NLR and PLR and the outcomes of acute inflammatory events. An optimal NLR cut-off value of 2.83 was identified for hospitalization for an inflammatory event. Logistic regression analysis showed that NLR &gt; 2.83 was associated with an increased risk of hospitalization for an inflammatory event. A PLR cut-off value of 165.2 was identified for hospitalization for an inflammatory event. However, logistic regression analysis showed that PLR &gt; 165.2 was not significantly associated with hospitalization for an inflammatory event. Our study findings suggest that the NLR has diagnostic value in predicting the risk of hospitalization for inflammatory events among patients with ARONJ.<\/jats:p>","DOI":"10.3390\/diagnostics12081836","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T23:37:29Z","timestamp":1659310649000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of Neutrophil\u2013Lymphocyte Ratio as a Marker in Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Retrospective Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Kazuto","family":"Kurohara","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasumi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokoro","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw\u20142014 Update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 Position Paper on Medication-Related Osteonecrosis of the Jaws\u20142022 Update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.joms.2015.07.005","article-title":"Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study","volume":"74","author":"Keskinruzgar","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/annonc\/mdj105","article-title":"Management of the Adverse Effects Associated with Intravenous Bisphosphonates","volume":"17","author":"Tanvetyanon","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Toledano-Fonseca, M., Cano, M.T., Inga, E., G\u00f3mez-Espa\u00f1a, A., Guil-Luna, S., Garc\u00eda-Ortiz, M.V., Mena-Osuna, R., De la Haba-Rodriguez, J.R., Rodr\u00edguez-Ariza, A., and Aranda, E. (2021). The Combination of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Liquid Biopsy Biomarkers Improves Prognosis Prediction in Metastatic Pancreatic Cancer. Cancers, 13.","DOI":"10.3390\/cancers13061210"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.21037\/jtd.2019.07.30","article-title":"Neutrophil-to-Lymphocyte Ratio as Prognostic Marker in Esophageal Cancer: A Systematic Review and Meta-Analysis","volume":"11","author":"Pirozzolo","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Oh, D., Pyo, J.-S., Chung, K.H., and Son, B.K. (2022). The Predicting Role of the Neutrophil-to-Lymphocyte Ratio for the Tumor Grade and Prognosis in Pancreatic Neuroendocrine Tumors. Diagnostics, 12.","DOI":"10.3390\/diagnostics12030737"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Schiefer, S., Wirsik, N.M., Kalkum, E., Seide, S.E., Nienh\u00fcser, H., M\u00fcller, B., Billeter, A., B\u00fcchler, M.W., Schmidt, T., and Probst, P. (2022). Systematic Review of Prognostic Role of Blood Cell Ratios in Patients with Gastric Cancer Undergoing Surgery. Diagnostics, 12.","DOI":"10.3390\/diagnostics12030593"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9731854","DOI":"10.1155\/2020\/9731854","article-title":"Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis","volume":"2020","author":"Kong","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2147\/TCRM.S107635","article-title":"The Role of Inflammation in Cardiovascular Diseases: The Predictive Value of Neutrophil-Lymphocyte Ratio as a Marker in Peripheral Arterial Disease","volume":"12","author":"Paquissi","year":"2016","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","article-title":"The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases","volume":"39","author":"Gasparyan","year":"2019","journal-title":"Ann. Lab. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.arcmed.2015.03.011","article-title":"Usefulness of Neutrophil\/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-Analysis","volume":"46","author":"Shao","year":"2015","journal-title":"Arch. Med. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cca.2016.12.007","article-title":"Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are 2 New Inflammatory Markers Associated with Pulmonary Involvement and Disease Activity in Patients with Dermatomyositis","volume":"465","author":"Yang","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The Inflammatory Response in Myocardial Infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Badescu, M.C., Rezus, E., Ciocoiu, M., Badulescu, O.V., Butnariu, L.I., Popescu, D., Bratoiu, I., and Rezus, C. (2022). Osteonecrosis of the Jaws in Patients with Hereditary Thrombophilia\/Hypofibrinolysis-From Pathophysiology to Therapeutic Implications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020640"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00774-020-01174-2","article-title":"Tooth Extraction in Mice Administered Zoledronate Increases Inflammatory Cytokine Levels and Promotes Osteonecrosis of the Jaw","volume":"39","author":"Soma","year":"2021","journal-title":"J. Bone Miner. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"606043","DOI":"10.3389\/fimmu.2021.606043","article-title":"The Role of the Immune Response in the Development of Medication-Related Osteonecrosis of the Jaw","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1634\/theoncologist.2010-0183","article-title":"Quality of Life Implications of Bisphosphonate-Associated Osteonecrosis of the Jaw","volume":"16","author":"Miksad","year":"2011","journal-title":"Oncologist"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e725","DOI":"10.4317\/jced.56307","article-title":"The Impact of Medication-Related Osteonecrosis of the Jaws on the Quality of Life in Cancer Patients","volume":"12","author":"Caminha","year":"2020","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1476-5381.2011.01592.x","article-title":"Zoledronate and Pamidronate Depress Neutrophil Functions and Survival in Mice","volume":"165","author":"Kuiper","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijom.2012.12.011","article-title":"The Effect of Bisphosphonate Therapy on Neutrophil Function: A Potential Biomarker","volume":"42","author":"Favot","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_22","first-page":"5","article-title":"Ratio of Neutrophil to Lymphocyte Counts--Rapid and Simple Parameter of Systemic Inflammation and Stress in Critically Ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2009.10.028","article-title":"Role of Polymorphonuclear Neutrophils in Atherosclerosis: Current State and Future Perspectives","volume":"210","author":"Baetta","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jjcc.2014.02.019","article-title":"Predictive Value of Elevated Neutrophil to Lymphocyte Ratio for Long-Term Cardiovascular Mortality in Peripheral Arterial Occlusive Disease","volume":"64","author":"Erturk","year":"2014","journal-title":"J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1365-2141.2004.05357.x","article-title":"Platelet Size Deviation Width, Platelet Large Cell Ratio, and Mean Platelet Volume Have Sufficient Sensitivity and Specificity in the Diagnosis of Immune Thrombocytopenia","volume":"128","author":"Kaito","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/0003319715591751","article-title":"Platelet to Lymphocyte Ratio as a Prognostic Marker of In-Hospital and Long-Term Major Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction","volume":"67","author":"Cetin","year":"2016","journal-title":"Angiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1538-7836.2004.00836.x","article-title":"Platelet Activation in Type 2 Diabetes Mellitus","volume":"2","author":"Ferroni","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between Inflammation and Thrombosis in Cardiovascular Pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1160\/TH13-02-0102","article-title":"Crosstalk between Platelets and the Complement System in Immune Protection and Disease","volume":"110","author":"Verschoor","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-199701000-00007","article-title":"Thrombophilia and Hypofibrinolysis: Pathophysiologies of Osteonecrosis","volume":"334","author":"Glueck","year":"1997","journal-title":"Clin. Orthop. Relat. Res."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/8\/1836\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:59:24Z","timestamp":1760140764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/8\/1836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["diagnostics12081836"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12081836","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2022,7,29]]}}}