{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:02:03Z","timestamp":1760238123859,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and type II PRCC, which can show multiple types of histologies and is more aggressive. The WHO 2022 classification eliminated the subcategorization of PRCC. Here, we present a histopathological case study with a 4-year follow-up diagnosed in 2018 as type I PRCC (WHO 2016) with intra-pyelocalyceal growth pattern in a 59-year-old male patient with a history of Type II diabetes mellitus, left-sided renal\u2013ureteral lithiasis, and benign hypertrophy of the prostate. Microscopically the tumor was composed of small cuboidal cells with inconspicuous nucleoli, arranged on a single layer of tubulo-papillary cores, and scant, foamy macrophages. The tumor had a non-infiltrative, expansive pyelocalyceal growth pattern. Immunohistochemically (IHC), the tumor cells were CK7-intense and diffusely positive, and stained granular for AMACR. Next-generation sequencing (NGS) was performed for the tumor and the normal adjacent tissue for in-depth pathological characterization. To our knowledge, this is the first reported case where a PRCC displays this unique intra-pyelocalyceal growth pattern, mimicking a urothelial cell carcinoma of the renal pelvis system.<\/jats:p>","DOI":"10.3390\/diagnostics12081904","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T21:03:50Z","timestamp":1659906230000},"page":"1904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma"],"prefix":"10.3390","volume":"12","author":[{"given":"Octavia Oana","family":"Harich","sequence":"first","affiliation":[{"name":"Department of Functional Sciences, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-4634","authenticated-orcid":false,"given":"Gheorghe-Emilian","family":"Olteanu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Discipline of Pulmonology, Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Timisoara Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Center of Expertise for Rare Lung Diseases, Clinical Hospital of Infectious Diseases and Pneumophthisiology \u201cDr. Victor Babes\u201d Timisoara, Gh. Adam Street No. 13, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-4178","authenticated-orcid":false,"given":"Ioana Maria","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, Discipline of Morphopathology, Anapatmol Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-4131","authenticated-orcid":false,"given":"Marius","family":"Benta","sequence":"additional","affiliation":[{"name":"Timis County Emergency Clinical Hospital \u201cPius Br\u00eenzeu\u201d Timisoara, No. 156 Liviu Rebreanu, 300723 Timisoara, Romania"},{"name":"XVision AI, Calea Torontalului No. 69, 021923 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavriliuc Oana","family":"Isabella","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Immuno-Physiology and Biotechnologies Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Timis County Emergency Clinical Hospital \u201cPius Br\u00eenzeu\u201d Timisoara, Center for Gene and Cellular Therapies in the Treatment of Cancer\u2014OncoGen, No. 156 Liviu Rebreanu, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paunescu","family":"Virgil","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Immuno-Physiology and Biotechnologies Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Timis County Emergency Clinical Hospital \u201cPius Br\u00eenzeu\u201d Timisoara, Center for Gene and Cellular Therapies in the Treatment of Cancer\u2014OncoGen, No. 156 Liviu Rebreanu, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4737-423X","authenticated-orcid":false,"given":"Florina Maria","family":"Bojin","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Immuno-Physiology and Biotechnologies Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Timis County Emergency Clinical Hospital \u201cPius Br\u00eenzeu\u201d Timisoara, Center for Gene and Cellular Therapies in the Treatment of Cancer\u2014OncoGen, No. 156 Liviu Rebreanu, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO classification of tumours of the urinary system and male genital organs\u2014Part A: Renal, penile, and testicular tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network (2016). Comprehensive molecular characterization of papillary renal-cell carcinoma. N. Engl. J. 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